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作者：Wang, Yuanyuan; Nan, Bei; Ye, Fei; Zhang, Zhe; Yang, Wentao; Pan, Bo; Wei, Fan; Duan, Lili; Li, Haicheng; Niu, Junhua; Ju, Aili; Liu, Yongqiang; Wang, Dantong; Zhang, Wenxin; Liu, Yifan; Gao, Shan
作者单位：Ocean University of China; Ocean University of China; University of Southern California; Yunnan University
摘要：Stable inheritance of DNA N6- methyladenine (6mA) is crucial for its biological functions in eukaryotes. Here, we identify two distinct methyltransferase (MTase) complexes, both sharing the catalytic subunit AMT1, but featuring AMT6 and AMT7 as their unique components, respectively. While the two complexes are jointly responsible for 6mA maintenance methylation, they exhibit distinct enzymology, DNA/chromatin affinity, genomic distribution, and knockout phenotypes. AMT7 complex, featuring high...
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作者：Butenko, Konstantin; Neudorfer, Clemens; Dembek, Till A.; Hollunder, Barbara; Meyer, Garance M.; Li, Ningfei; Oxenford, Simon; Bahners, Bahne H.; Al-Fatly, Bassam; Lofredi, Roxanne; Gordon, Evan M.; Dosenbach, Nico U. F.; Ganos, Christos; Hallett, Mark; Jinnah, Hyder A.; Starr, Philip A.; Ostrem, Jill L.; Wu, Yiwen; Zhang, Chencheng; Fox, Michael D.; Horn, Andreas
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Cologne; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Toronto; University Health Network Toronto; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); NIH National Institute of Neurological Disorders & Stroke (NINDS); Emory University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as the primary target, recently, stimulation of the subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not been studied in depth. Indeed, historical targets that have been used for surgical treatment of dystonia are directly adjacent to the STN. Further, multiple types of dystonia exist, and outcomes are variable, suggestin...
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作者：Yao, Yao; Pankow, Robert M.; Huang, Wei; Wu, Cui; Gao, Lin; Cho, Yongjoon; Chen, Jianhua; Zhang, Dayong; Sharma, Sakshi; Liu, Xiaoxue; Wang, Yuyang; Peng, Bo; Chung, Sein; Cho, Kilwon; Fabiano, Simone; Ye, Zunzhong; Ping, Jianfeng; Marks, Tobin J.; Facchetti, Antonio
作者单位：Northwestern University; Northwestern University; Zhejiang University; University of Texas System; University of Texas El Paso; Yunnan University; University System of Georgia; Georgia Institute of Technology; Pohang University of Science & Technology (POSTECH); Linkoping University
摘要：Human perception systems are highly refined, relying on an adaptive, plastic, and event- driven network of sensory neurons. Drawing inspiration from Nature, neuromorphic perception systems hold tremendous potential for efficient multisensory signal processing in the physical world; however, the development of an efficient artificial neuron with a widely calibratable spiking range and reduced footprint remains chalcomplementary circuitry enabled by an advanced n- type polymer for balanced p- /n...
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作者：Corrales, Rosa Milagros; Vincent, Jeremy; Crobu, Lucien; Neish, Rachel; Nepal, Binita; Espeut, Julien; Pasquier, Gregoire; Gillard, Ghislain; Cazevieille, Chantal; Mottram, Jeremy C.; Wetzel, Dawn M.; Sterkers, Yvon; Rogowski, Krzysztof; Leveque, Maude F.
作者单位：Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; University of York - UK; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier
摘要：Tubulin detyrosination has been implicated in various human disorders and is important for regulating microtubule dynamics. While in most organisms this modification is restricted to alpha-tubulin, in trypanosomatid parasites, it occurs on both alpha- and beta-tubulin. Here, we show that in Leishmania, a single vasohibin (LmVASH) enzyme is responsible for differential kinetics of alpha- and beta-tubulin detyrosination. LmVASH knockout parasites, which are completely devoid of detyrosination, s...
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作者：Hutchison, William; Sugden, Patrick; Burke, Andrea; Abbott, Peter; Ponomareva, Vera V.; Dirksen, Oleg; Portnyagin, Maxim, V; Macinnes, Breanyn; Bourgeois, Joanne; Fitzhugh, Ben; Verkerk, Magali; Aubry, Thomas J.; Engwell, Samantha L.; Svensson, Anders; Chellman, Nathan J.; Mcconnell, Joseph R.; Davies, Siwan; Sigl, Michael; Plunkett, Gill
作者单位：University of St Andrews; University of Bern; University of Bern; Institute of Volcanology & Seismology, Far Eastern Branch, RAS; Russian Academy of Sciences; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Central Washington University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Exeter; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; University of Copenhagen; Niels Bohr Institute; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Swansea University; Queens University Belfast
摘要：Polar ice cores and historical records evidence a large-magnitude volcanic eruption in 1831 CE. This event was estimated to have injected similar to 13 Tg of sulfur (S) into the stratosphere which produced various atmospheric optical phenomena and led to Northern Hemisphere climate cooling of similar to 1 degrees C. The source of this volcanic event remains enigmatic, though one hypothesis has linked it to a modest phreatomagmatic eruption of Ferdinandea in the Strait of Sicily, which may have...
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作者：Layous, Majed; Gildor, Tsvia; Nehrer, Tovah; Qassem, Areen; Wolfenson, Haguy; de-Leon, Smadar Ben- Tabou
作者单位：University of Haifa; Technion Israel Institute of Technology; Rappaport Faculty of Medicine
摘要：Biomineralization is the utilization of different minerals by a vast array of organisms to form hard tissues and shape them in various forms. Within this diversity, a common feature of all mineralized tissues is their high stiffness, implying that mechanosensing could be commonly used in biomineralization. Yet, the role of mechanosensing in biomineralization is far from clear. Here, we use the sea urchin larval skeletogenesis to investigate the role of substrate stiffness and focal adhesion ki...
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作者：Nishikino, Tatsuro; Takekawa, Norihiro; Kishikawa, Jun-ichi; Hirose, Mika; Kojima, Seiji; Homma, Michio; Kato, Takayuki; Imada, Katsumi
作者单位：University of Osaka; Nagoya Institute of Technology; Nagoya Institute of Technology; University of Osaka; Kyoto Institute of Technology; Nagoya University
摘要：Many bacteria swim in liquid or swarm on surface using the flagellum rotated by a motor driven by specific ion flow. The motor consists of the rotor and stator, and the stator converts the energy of ion flow to mechanical rotation. However, the ion pathway and the mechanism of stator rotation coupled with specific ion flow are still obscure. Here, we determined the structures of the sodium- driven stator of Vibrio, namely PomAB, in the presence and absence of sodium ions and the structure with...
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作者：Reeder, T. R.; Titum, Paraj; Kindervater, J.; Stewart, V. J.; Ye, Q.; Qiu, Y.; Maliszewskyj, N.; Mcqueen, T. M.; Broholm, C. L.
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; National Institute of Standards & Technology (NIST) - USA; Johns Hopkins University; Johns Hopkins University
摘要：Introducing an experimental technique of time-resolved inelastic neutron scattering (TRINS), we explore the time-dependent effects of resonant pulsed microwaves on the molecular magnet Cr8F8Piv16. The octagonal rings of magnetic Cr3+ atoms with antiferromagnetic interactions form a singlet ground state with a weakly split triplet of excitations at 0.8 meV. A 4.6 tesla field was applied to tune the splitting between two members of the triplet excited level | 1 i <-> | 2 i to resonance with 105 ...
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作者：Zhu, Xintong; Pomerenk, Olivia; Ristroph, Leif
作者单位：New York University
摘要：Mechanical systems with moving points of contact-including rolling, sliding, and impacts-are common in engineering applications and everyday experiences. The challenges in analyzing such systems are compounded when an object dynamically explores the complex surface shape of a moving structure, as arises in familiar but poorly understood contexts such as hula hooping. We study this activity as a unique form of mechanical levitation against gravity and identify the conditions required for the st...
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作者：Heyer, Alexander J.; Haddad, Abed; Scott, Racquel; Kowach, Glen; Solomon, Edward I.
作者单位：Stanford University; City University of New York (CUNY) System; City College of New York (CUNY); Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
摘要：Number 1A, 1948 by Jackson Pollock is a quintessential example of his action painting technique where ropes of color, drips of black, and pools of white coalesce into the layered dynamism that defines his style. While past work has identified the red and yellow pigments that form part of his core palette, the vibrant blue in the painting has remained unassigned. In this study resonance Raman spectroscopy is used to assign the blue in the painting as manganese blue. This assignment offers criti...
