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作者：Runion, Kyle D.; Alber, Merryl; Mishra, Deepak R.; Lever, Mark A.; Hladik, Christine M.; O'Connell, Jessica L.
作者单位：University of Texas System; University of Texas Austin; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; Georgia Southern University; Colorado State University System; Colorado State University Fort Collins
摘要：Salt marshes provide valuable ecosystem services but are vulnerable to drowning with avoid drowning by building marsh surface elevation. Reductions in BGB can serve as an early warning sign of marsh deterioration, as they often precede decreases in aboveground biomass (AGB). However, landscape- scale BGB assessments to predict broad trends in marsh deterioration have not been previously available. We applied the Belowground Ecosystem Resiliency Model (BERM) to assess standing stocks and trends...
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作者：Zhang, Zheng; Meng, Yichen; Lin, Tao; Zhang, Zhanrong; Tao, Zhengbo; Yin, Haozan; Yang, Fu; Zhou, Xuhui
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作者：Richardson, Rekha M. Dhillon-; Haugan, Alexandra K.; Lyons, Luke W.; McKenna, Joseph K.; Bronner, Marianne E.; Martik, Megan L.
作者单位：University of California System; University of California Berkeley; California Institute of Technology
摘要：During vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest (CdNC) cells that migrate to the heart and form a variety of cardiovascular derivatives. Here, by integrating bulk and single cell RNA- seq with ATAC- seq, we identify a gene regulatory subcircuit specific to migratory cardiac crest cells composed of key transcription factors egr1, sox9a, tfap2a, and ets1. Notably, we show that cells expressing the canonical neural cres...
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作者：Day, Trevor A.; Bigham, Abigail W.; Brutsaert, Tom D.
作者单位：Mount Royal University; University of California System; University of California Los Angeles; Syracuse University
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作者：Kuhn, Hunter W.; Smither, Madeleine R.; Jin, Rachel J.; Collins, Christina A.; Ma, Hongming; Sina, Jason; Gaut, Joseph P.; Diamond, Michael S.; Hunstad, David A.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：The alpha- hemolysin (HlyA) of uropathogenic Escherichia coli (UPEC) is a pore-forming toxin (PFT) that is thought to function by disrupting the host cell plasma membrane. Although CD18 (LFA-1) has been implicated as a receptor on myeloid cells, the mechanisms underlying HlyA cytotoxicity to epithelial cells are poorly defined. Here, we show that HlyA secretion by UPEC markedly intensifies renal tubular epithelial injury in a murine model of ascending pyelonephritis. A CRISPR-Cas9 loss-of-func...
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作者：Nesbitt, Jason
作者单位：Tulane University
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作者：Toomey, Christopher B.; Pflugmacher, Savanna; Park, Kamalu; Pihl, Jessica; Novak, Sammy Weiser; Rodriguez, Jessica; Jalali, Maryam; Jung, Jaesoo; Mozafari, Madeline; Omran, Sima P.; Pormir, Cameron K.; Hauer, Jill; Painter, Chelsea; Walker, Evan; Huang, Alex S.; Boassa, Daniela; Handa, James T.; Aastrup, Teodor; Gordts, Philip L. S. M.; Esko, Jeffrey D.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; Johns Hopkins University; Johns Hopkins Medicine; University of California System; University of California San Diego
摘要：Lipoprotein retention in Bruch's membrane is a key event in the pathobiology of early and intermediate age-related macular degeneration (AMD). However, the mechanism of lipoprotein retention in BrM is unknown. Given the established role of glycosaminoglycans (GAG) in binding lipoproteins, our laboratory sought to determine the role of GAGs in AMD BrM. In this study, BrM GAG content in AMD pathobiology was analyzed in human postmortem tissue. Strikingly, increased levels of highly sulfated hepa...
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作者：Yuan, Xueying; Yan, Lu; Chen, Qinfu; Zhu, Shukai; Zhou, Xinyu; Zeng, Ling-Hui; Liu, Mingjie; He, Xiaojing; Huang, Jun; Lu, Weiguo; Zhang, Long; Yan, Haiyan; Wang, Fangwei
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作者：Zhao, Yue; Zhang, Keren; Li, Guo; Wang, Yuming; Ding, Xiaoyang; Wang, Shuo; Pang, Xi; Zhao, Xueru; Yu, Yue; Liu, Jiaqi; Yu, Tingting; Bao, Guixian; Wang, Tianya; Ni, Zhongfu; Xin, Mingming; Liu, Bao; Wendel, Jonathan F.; Zhang, Zhibin; Gong, Lei
作者单位：Northeast Normal University - China; Jilin Academy of Agricultural Sciences; China Agricultural University; China Agricultural University; Iowa State University
摘要：The union of two or more different nuclear genomes with maternally inherited organellar genomes may lead to cytonuclear incompatibilities in plant allopolyploids. These incompatibilities may be reconciled by coevolutionary responses at the genomic and transcriptional levels. To date, the relationship between extent of divergence among parental organellar genomes and cytonuclear coevolutionary responses remains largely unexplored. Here, we studied transcriptional cytonuclear expression in synth...
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作者：Hoehne, Mila Y.; Milani, Wiebke; Ramlow, Kirsten; Bogdan, Sven
作者单位：Philipps University Marburg
摘要：Collective cell migration is a key driver of tissue morphogenesis and cancer invasion. Here, we identified the tumor suppressor Ras association domain-containing protein 8 (RASSF8) as a WAVE interactor required for border cell migration. RASSF8 colocalizes with F-actin and cell adhesion molecules at border cell-border cell contacts. Loss of RASSF8 function results in border cell cohesion defects, a phenotype associated with changes in the localization of the Echinoid (Ed) and Coracle (Cora). C...
