2024

最新文章

• Germline variants alter immune surveillance AI翻译
  作者：Waddell, Nicola; Addala, Venkateswar
  作者单位：QIMR Berghofer Medical Research Institute
  摘要：The formation of tumors is complex and multifaceted, involving cancer cell-intrinsic and -extrinsic factors. An important influence on tumorigenesis is the immune system, by which immune surveillance (and subsequent elimination) provides a selective pressure that causes the evolution of tumor cells to evade detection (immunoediting). Cancer immunoediting involves three phases: immunosurveillance to eliminate tumor cells; the coexistence of tumor and immune cells through equilibrium; and immune...
• NIH aide pressed on emails AI翻译
  作者：Brainard, Jeffrey
• Research faces cuts as Dutch shift to the right AI翻译
  作者：Enserink, Martin
  摘要：New coalition to scrap science and innovation funds, roll back environmental measures
• Finding the big picture AI翻译
  作者：Kundu, Anirban
• Active biointegrated living electronics for managing inflammation AI翻译
  作者：Shi, Jiuyun; Kim, Saehyun; Li, Pengju; Dong, Fuying; Yang, Chuanwang; Nam, Bryan; Han, Chi; Eig, Ethan; Shi, Lewis L.; Niu, Simiao; Yue, Jiping; Tian, Bozhi
  作者单位：University of Chicago; University of Chicago; Rutgers University System; Rutgers University New Brunswick; University of Chicago; Columbia University; University of Chicago; University of Chicago; University of Chicago Medical Center; University of Chicago
  摘要：Seamless interfaces between electronic devices and biological tissues stand to revolutionize disease diagnosis and treatment. However, biological and biomechanical disparities between synthetic materials and living tissues present challenges at bioelectrical signal transduction interfaces. We introduce the active biointegrated living electronics (ABLE) platform, encompassing capabilities across the biogenic, biomechanical, and bioelectrical properties simultaneously. The living biointerface, c...
• A neutralizing antibody prevents postfusion transition of measles virus fusion protein AI翻译
  作者：Zyla, Dawid S.; Della Marca, Roberta; Niemeyer, Gele; Zipursky, Gillian; Stearns, Kyle; Leedale, Cameron; Sobolik, Elizabeth B.; Callaway, Heather M.; Hariharan, Chitra; Peng, Weiwei; Parekh, Diptiben; Marcink, Tara C.; Diaz Avalos, Ruben; Horvat, Branka; Mathieu, Cyrille; Snijder, Joost; Greninger, Alexander L.; Hastie, Kathryn M.; Niewiesk, Stefan; Moscona, Anne; Porotto, Matteo; Saphire, Erica Ollmann
  作者单位：La Jolla Institute for Immunology; Columbia University; Columbia University; Universita della Campania Vanvitelli; University of Lubeck; University System of Ohio; Ohio State University; University of Washington; University of Washington Seattle; Utrecht University; Utrecht University; Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Columbia University; Columbia University; University of California System; University of California San Diego; Montana State University System; Montana State University Bozeman
  摘要：Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the generalpopulation declines and as populations of immunocompromised individuals, who cannot be vaccinated,increase. There are no approved therapeutics for MeV. Neutralizing antibodies targeting viral fusionare one potential therapeutic approach but have not yet been structurally characterized or advanced toclinical use. We present cryo-electron microscopy (cryo-EM) structures of prefusion F alone [...
• Multistage maturation optimizes vision AI翻译
  作者：Mamassian, Pascal
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS)
  摘要：Late development of color vision improves object recognition
• Genetic regulation of cell type-specific chromatin accessibility shapes brain disease etiology AI翻译
  作者：Zeng, Biao; Bendl, Jaroslav; Deng, Chengyu; Lee, Donghoon; Misir, Ruth; Reach, Sarah M.; Kleopoulos, Steven P.; Auluck, Pavan; Marenco, Stefano; Lewis, David A.; Haroutunian, Vahram; Ahituv, Nadav; Fullard, John F.; Hoffman, Gabriel E.; Roussos, Panos
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount Sinai; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center
  摘要：Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons from 616 human postmortem brains and identified 34,539 open chromatin regions with chromatin accessibility quantitative trait loci (caQTLs). Only 10.4% of caQTLs are shared between neurons and non-neurons, which supports cell type-specific genetic regulation of the brain regulome. Incorpo...
• The value of field research in academia AI翻译
  作者：Rafiq, Kasim; Jordan, Neil R.; McNutt, J. Weldon; Neelo, John; Attias, Nina; Boersma, Dee; Palmer, Meredith S.; Ruesink, Jennifer; Abrahms, Briana
  作者单位：University of Washington; University of Washington Seattle; University of New South Wales Sydney; Taronga Conservation Society Australia; University of Washington; University of Washington Seattle
• COMMUNICATION BREAKDOWN AI翻译
  作者：Leslie, Mitch
  摘要：Faulty messaging between organs could make us old