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作者：Zhang, Jianping; Jiang, Leping; Yu, Lupeng; Huan, Xiujia; Zhou, Liping; Wang, Changsheng; Jin, Jianhui; Zuo, Xinxin; Wu, Naiqin; Zhao, Zhijun; Sun, Hanlong; Yu, Zhaoyuan; Zhang, Guoping; Zhu, Jiangping; Wu, Zhenlei; Dong, Yajie; Fan, Baoshuo; Shen, Caiming; Lu, Houyuan
作者单位：Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; Linyi University; Peking University; Fujian Normal University; Shandong University; Hebei Normal University; Yunnan Normal University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Rice (Oryza sativa) serves as a staple food for more than one-third of the global population. However, its journey from a wild gathered food to domestication remains enigmatic, sparking ongoing debates in the biological and anthropological fields. Here, we present evidence of rice phytoliths sampled from two archaeological sites in China, Shangshan and Hehuashan, near the lower reaches of the Yangtze River. We demonstrate the growth of wild rice at least 100,000 years before present, its initi...
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作者：Daskalakis, Nikolaos P.; Iatrou, Artemis; Chatzinakos, Chris; Jajoo, Aarti; Snijders, Clara; Wylie, Dennis; Dipietro, Christopher P.; Tsatsani, Ioulia; Chen, Chia-Yen; Pernia, Cameron D.; Soliva-Estruch, Marina; Arasappan, Dhivya; Bharadwaj, Rahul A.; Collado-Torres, Leonardo; Wuchty, Stefan; Alvarez, Victor E.; Dammer, Eric B.; Deep-Soboslay, Amy; Duong, Duc M.; Eagles, Nick; Huber, Bertrand R.; Huuki, Louise; Holstein, Vincent L.; Logue, Mark W.; Lugenbuhl, Justina F.; Maihofer, Adam X.; Miller, Mark W.; Nievergelt, Caroline M.; Pertea, Geo; Ross, Deanna; Sendi, Mohammad S. E.; Sun, Benjamin B.; Tao, Ran; Tooke, James; Wolf, Erika J.; Zeier, Zane; Berretta, Sabina; Champagne, Frances A.; Hyde, Thomas; Seyfried, Nicholas T.; Shin, Joo Heon; Weinberger, Daniel R.; Nemeroff, Charles B.; Kleinman, Joel E.; Ressler, Kerry J.
作者单位：Harvard University; Harvard University Medical Affiliates; McLean Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; State University of New York (SUNY) System; SUNY Downstate Health Sciences University; University of Texas System; University of Texas Austin; Maastricht University; Biogen; Johns Hopkins University; Johns Hopkins Medicine; University of Miami; University of Miami; Boston University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Emory University; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; Boston University; Boston University; Boston University; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of Texas System; University of Texas Austin; University of Miami; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of Texas System; University of Texas Austin
摘要：The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) included the central nucleus of the amygdala, hippocampal dentate gyrus, and medial prefrontal cortex (mPFC). Genes and exons within the mPFC carried most disease signals replicated across two independent cohorts. Pathways pointed to immune function, neuronal and synaptic regulation, and stress hormones. Multiomi...
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作者：Huang, Weiyuan; Liu, Tongchao; Yu, Lei; Wang, Jing; Zhou, Tao; Liu, Junxiang; Li, Tianyi; Amine, Rachid; Xiao, Xianghui; Ge, Mingyuan; Ma, Lu; Ehrlich, Steven N.; Holt, Martin V.; Wen, Jianguo; Amine, Khalil
作者单位：United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
摘要：Transitioning from polycrystalline to single-crystalline nickel-rich cathodes has garnered considerable attention in both academia and industry, driven by advantages of high tap density and enhanced mechanical properties. However, cathodes with high nickel content (>70%) suffer from substantial capacity degradation, which poses a challenge to their commercial viability. Leveraging multiscale spatial resolution diffraction and imaging techniques, we observe that lattice rotations occur universa...
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作者：Nusinovich, Yevgeniya
摘要：A cell-by-cell look at neuropsychiatric diseases
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作者：Fan, Penglai; Lawes, Michael J.; Liu, Ruoshuang; Zhou, Qihai
作者单位：Guangxi Normal University; Guangxi Normal University; University of Kwazulu Natal; University of Malaysia Sarawak
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作者：Emani, Prashant S.; Liu, Jason J.; Clarke, Declan; Jensen, Matthew; Warrell, Jonathan; Gupta, Chirag; Meng, Ran; Lee, Che Yu; Xu, Siwei; Dursun, Cagatay; Lou, Shaoke; Chen, Yuhang; Chu, Zhiyuan; Galeev, Timur; Hwang, Ahyeon; Li, Yunyang; Ni, Pengyu; Zhou, Xiao; Bakken, Trygve E.; Bendl, Jaroslav; Bicks, Lucy; Chatterjee, Tanima; Cheng, Lijun; Cheng, Yuyan; Dai, Yi; Duan, Ziheng; Flaherty, Mary; Fullard, John F.; Gancz, Michael; Garrido-Martin, Diego; Gaynor-Gillett, Sophia; Grundman, Jennifer; Hawken, Natalie; Henry, Ella; Hoffman, Gabriel E.; Huang, Ao; Jiang, Yunzhe; Jin, Ting; Jorstad, Nikolas L.; Kawaguchi, Riki; Khullar, Saniya; Liu, Jianyin; Liu, Junhao; Liu, Shuang; Ma, Shaojie; Margolis, Michael; Mazariegos, Samantha; Moore, Jill; Moran, Jennifer R.; Nguyen, Eric; Phalke, Nishigandha; Pjanic, Milos; Pratt, Henry; Quintero, Diana; Rajagopalan, Ananya S.; Riesenmy, Tiernon R.; Shedd, Nicole; Shi, Manman; Spector, Megan; Terwilliger, Rosemarie; Travaglini, Kyle J.; Wamsley, Brie; Wang, Gaoyuan; Xia, Yan; Xiao, Shaohua; Yang, Andrew C.; Zheng, Suchen; Gandal, Michael J.; Lee, Donghoon; Lein, Ed S.; Roussos, Panos; Sestan, Nenad; Weng, Zhiping; White, Kevin P.; Won, Hyejung; Girgenti, Matthew J.; Zhang, Jing; Wang, Daifeng; Geschwind, Daniel; Gerstein, Mark
作者单位：Yale University; Yale University; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Irvine; University of California System; University of California Irvine; Yale University; Allen Institute for Brain Science; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Barcelona; Cornell University; Weill Cornell Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; University of California System; University of California Los Angeles; Yale University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Yale University; Yale University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; National University of Singapore; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Yale University
摘要：Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics datasets into a resource comprising >2.8 million nuclei from the prefrontal cortex across 388 individuals. For 28 cell types, we assessed population-level variation in expression and chromatin across gene families and drug targets. We identified >5...
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作者：Incorvaia, Darren
摘要：DNA study implicates medieval warfare and colonial trade
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作者：Wen, Cindy; Margolis, Michael; Dai, Rujia; Zhang, Pan; Przytycki, Pawel F.; Vo, Daniel D.; Bhattacharya, Arjun; Matoba, Nana; Tang, Miao; Jiao, Chuan; Kim, Minsoo; Tsai, Ellen; Hoh, Celine; Ayguen, Nil; Walker, Rebecca L.; Chatzinakos, Christos; Clarke, Declan; Pratt, Henry; Peters, Mette A.; Gerstein, Mark; Daskalakis, Nikolaos P.; Weng, Zhiping; Jaffe, Andrew E.; Kleinman, Joel E.; Hyde, Thomas M.; Weinberger, Daniel R.; Bray, Nicholas J.; Sestan, Nenad; Geschwind, Daniel H.; Roeder, Kathryn; Gusev, Alexander; Pasaniuc, Bogdan; Stein, Jason L.; Love, Michael I.; Pollard, Katherine S.; Liu, Chunyu; Gandal, Michael J.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; State University of New York (SUNY) System; SUNY Upstate Medical University; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; McLean Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; University of Massachusetts System; University of Massachusetts Worcester; Yale University; Yale University; Yale University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Cardiff University; Yale University; Yale University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Carnegie Mellon University; Carnegie Mellon University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); Central South University
摘要：Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanisms is challenging without a unified regulatory atlas. Across 672 diverse developing human brains, we identified 15,752 genes harboring gene, isoform, and/or splicing quantitative trait loci, mapping 3739 to cellular contexts. Gene expression heritability drop...
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作者：Bengio, Yoshua; Hinton, Geoffrey; Yao, Andrew; Song, Dawn; Abbeel, Pieter; Darrell, Trevor; Harari, Yuval Noah; Zhang, Ya-Qin; Xue, Lan; Shalev-Shwartz, Shai; Hadfield, Gillian; Clune, Jeff; Maharaj, Tegan; Hutter, Frank; Baydin, Atilim Gunes; McIlraith, Sheila; Gao, Qiqi; Acharya, Ashwin; Krueger, David; Dragan, Anca; Torr, Philip; Russell, Stuart; Kahneman, Daniel; Brauner, Jan; Mindermann, Soren
作者单位：Mila Quebec Artificial Intelligence Institute; Universite de Montreal; University of Toronto; Vector Institute for Artificial Intelligence; Tsinghua University; University of California System; University of California Berkeley; Hebrew University of Jerusalem; Tsinghua University; Tsinghua University; Hebrew University of Jerusalem; University of Toronto; University of Toronto; University of British Columbia; University of Toronto; University of Freiburg; University of Oxford; East China University Political Science & Law; RAND Corporation; University of Cambridge; University of Oxford; Princeton University
摘要：Preparation requires technical research and development, as well as adaptive, proactive governance
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作者：Heintz, Kasper E.; Watson, Darach; Brammer, Gabriel; Vejlgaard, Simone; Hutter, Anne; Strait, Victoria B.; Matthee, Jorryt; Oesch, Pascal A.; Jakobsson, Pall; Tanvir, Nial R.; Laursen, Peter; Naidu, Rohan P.; Mason, Charlotte A.; Killi, Meghana; Jung, Intae; Hsiao, Tiger Yu-Yang; Coe, Dan; Haro, Pablo Arrabal; Finkelstein, Steven L.; Toft, Sune
作者单位：University of Copenhagen; Niels Bohr Institute; Institute of Science & Technology - Austria; University of Geneva; University of Iceland; University of Leicester; Massachusetts Institute of Technology (MIT); Space Telescope Science Institute; Johns Hopkins University; National Science Foundation (NSF); University of Texas System; University of Texas Austin
摘要：Primordial neutral atomic gas, mostly composed of hydrogen, is the raw material for star formation in galaxies. However, there are few direct constraints on the amount of neutral atomic hydrogen (H i) in galaxies at early cosmic times. We analyzed James Webb Space Telescope (JWST) near-infrared spectroscopy of distant galaxies, at redshifts greater than or similar to 8. From a sample of 12 galaxies, we identified three that show strong damped Lyman-alpha absorption due to H i in their local su...
