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作者：Houlahan, Kathleen E.; Khan, Aziz; Greenwald, Noah F.; Vivas, Cristina Sotomayor; West, Robert B.; Angelo, Michael; Curtis, Christina
作者单位：Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and why these differences arise. Somatic genomic aberrations occur within the context of a highly variable germline genome. Interrogating 5870 breast cancer lesions, we demonstrated that germline-derived epitopes in recurrently amplified genes influence somatic evolution by mediating immunoediting. Individuals with a high germline-epitope burden in human epidermal growth fact...
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作者：Langmore, N. E.; Grealy, A.; Noh, H. -j.; Medina, I.; Skeels, A.; Grant, J.; Murray, K. D.; Kilner, R. M.; Holleley, C. E.
作者单位：Australian National University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Melbourne; University of Cambridge
摘要：Coevolution between interacting species is thought to increase biodiversity, but evidence linking microevolutionary processes to macroevolutionary patterns is scarce. We leveraged two decades of behavioral research coupled with historical DNA analysis to reveal that coevolution with hosts underpins speciation in brood-parasitic bronze-cuckoos. At a macroevolutionary scale, we show that highly virulent brood-parasitic taxa have higher speciation rates and are more likely to speciate in sympatry...
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作者：Liu, Zhi; Hu, Xiaonan; Bo, Renheng; Yang, Youzhou; Cheng, Xu; Pang, Wenbo; Liu, Qing; Wang, Yuejiao; Wang, Shuheng; Xu, Shiwei; Shen, Zhangming; Zhang, Yihui
作者单位：Tsinghua University; Tsinghua University; National University of Singapore; National University of Singapore
摘要：Human skin sensing of mechanical stimuli originates from transduction of mechanoreceptors that converts external forces into electrical signals. Although imitating the spatial distribution of those mechanoreceptors can enable developments of electronic skins capable of decoupled sensing of normal/shear forces and strains, it remains elusive. We report a three-dimensionally (3D) architected electronic skin (denoted as 3DAE-Skin) with force and strain sensing components arranged in a 3D layout t...
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作者：Phelan, Meagan
摘要：Award recognizes individuals whose work best underpins the Science Breakthrough of the Year
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作者：Rice, Aaron N.
作者单位：Cornell University; Cornell University
摘要：Rich underwater soundscapes await those who listen closely Rich underwater soundscapes await those who listen closely
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作者：Reardon, Sara
摘要：Mouse study contradicts landmark finding, but some question its methodology
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作者：Blinder, Collin
摘要：Before a computer crash, venerable NASA probe entered mysterious new region of space
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作者：Couzin-Frankel, Jennifer
摘要：New study questions often-implied benefit for participants
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作者：Green, Fergus; Bois von Kursk, Olivier; Muttitt, Greg; Pye, Steve
作者单位：University of London; University College London; University of London; University College London
摘要：Global production and use of fossil fuels continue to expand, making the goals of the Paris Agreement ever more difficult to achieve. Echoing calls made by climate advocates for years, the groundbreaking decision at the United Nations (UN) climate meeting in late 2023 (COP28) calls on parties to contribute to & mldr;transitioning away from fossil fuels in energy systems. The normative case for ultimately phasing out fossil fuels is strong, and in some cases, it is feasible to phase out project...
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作者：Quintero, Ignacio; Lartillot, Nicolas; Morlon, Helene
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite Claude Bernard Lyon 1; VetAgro Sup
摘要：The evolutionary histories of major clades, including mammals, often comprise changes in their diversification dynamics, but how these changes occur remains debated. We combined comprehensive phylogenetic and fossil information in a new birth-death diffusion model that provides a detailed characterization of variation in diversification rates in mammals. We found an early rising and sustained diversification scenario, wherein speciation rates increased before and during the Cretaceous-Paleogen...
