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作者：Allen, Jennifer; Watts, Duncan J.; Rand, David G.
作者单位：Massachusetts Institute of Technology (MIT); University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Low uptake of the COVID-19 vaccine in the US has been widely attributed to social media misinformation. To evaluate this claim, we introduce a framework combining lab experiments (total N = 18,725), crowdsourcing, and machine learning to estimate the causal effect of 13,206 vaccine-related URLs on the vaccination intentions of US Facebook users (N approximate to 233 million). We estimate that the impact of unflagged content that nonetheless encouraged vaccine skepticism was 46-fold greater tha...
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作者：Thorp, H. Holden
摘要：Last week, Science, Science Advances, and Science Translational Medicine published an extensive set of papers from the PsychENCODE Consortium, a multi-institutional collaboration whose aim is to study the genetics of neuropsychiatric disorders such as bipolar disorder, autism spectrum disorder, and schizophrenia. The papers, collectively called PsychENCODE2, apply advances in single-cell and multi-omic technologies to postmortem brain tissue to elucidate factors that may help explain and devel...
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作者：Princen, Katrien; Van Dooren, Tom; van Gorsel, Marit; Louros, Nikolaos; Yang, Xiaojuan; Dumbacher, Michael; Bastiaens, Ilse; Coupet, Kristel; Dupont, Shana; Cuveliers, Eva; Lauwers, Annick; Laghmouchi, Mohamed; Vanwelden, Thomas; Carmans, Sofie; Van Damme, Nele; Duhamel, Hein; Vansteenkiste, Seppe; Prerad, Jovan; Pipeleers, Karolien; Rodiers, Olivier; De Ridder, Liese; Claes, Sofie; Busschots, Yoni; Pringels, Lentel; Verhelst, Vanessa; Debroux, Eveline; Brouwer, Marinka; Lievens, Sam; Tavernier, Jan; Farinelli, Melissa; Hughes-Asceri, Sandrine; Voets, Marieke; Winderickx, Joris; Wera, Stefaan; de Wit, Joris; Schymkowitz, Joost; Rousseau, Frederic; Zetterberg, Henrik; Cummings, Jeffrey L.; Annaert, Wim; Cornelissen, Tom; De Winter, Hans; De Witte, Koen; Fivaz, Marc; Griffioen, Gerard
作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Ghent University; KU Leuven; University of Gothenburg; Sahlgrenska University Hospital; University of London; University College London; University of London; University College London; University of Wisconsin System; University of Wisconsin Madison; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Antwerp
摘要：Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium homeostasis in cell-based models of tau pathology. Aberrant tau accumulation leads to uncontrolled activation of store-operated calcium channels (SOCCs) by remodeling septin filaments at the cell cortex. Binding of ReS19-T to septins restores filament assembly in the disease state and restrains...
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作者：Cooks, R. Graham; Holden, Dylan T.
作者单位：Purdue University System; Purdue University
摘要：Charged microdroplets accelerate mineral disintegration
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作者：Baribi-Bartov, Sahar; Swire-Thompson, Briony; Grinberg, Nir
作者单位：Ben-Gurion University of the Negev; Northeastern University; Harvard University
摘要：Governments may have the capacity to flood social media with fake news, but little is known about the use of flooding by ordinary voters. In this work, we identify 2107 registered US voters who account for 80% of the fake news shared on Twitter during the 2020 US presidential election by an entire panel of 664,391 voters. We found that supersharers were important members of the network, reaching a sizable 5.2% of registered voters on the platform. Supersharers had a significant overrepresentat...
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作者：Shao, Wenhao; Kim, Jeong Hui; Simon, Jeffrey; Nian, Zhichen; Baek, Sung-Doo; Lu, Yuan; Fruhling, Colton B.; Yang, Hanjun; Wang, Kang; Park, Jee Yung; Huang, Libai; Yu, Yi; Boltasseva, Alexandra; Savoie, Brett M.; Shalaev, Vladimir M.; Dou, Letian
作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; ShanghaiTech University; ShanghaiTech University; Purdue University System; Purdue University; Chinese Academy of Sciences; Institute of Chemistry, CAS; Purdue University System; Purdue University
摘要：Layered metal-halide perovskites, or two-dimensional perovskites, can be synthesized in solution, and their optical and electronic properties can be tuned by changing their composition. We report a molecular templating method that restricted crystal growth along all crystallographic directions except for [110] and promoted one-dimensional growth. Our approach is widely applicable to synthesize a range of high-quality layered perovskite nanowires with large aspect ratios and tunable organic-ino...
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作者：van der Linden, Sander; Kyrychenko, Yara
作者单位：University of Cambridge
摘要：Misinformation is viewed as a threat to science, public health, and democracies worldwide ( 1 ). Experts define misinformation as content that is false or misleading, such that it contains some facts but is otherwise manipulative ( 2 , 3 ). Yet, the importance of this distinction has remained unquantified. On pages 978 and 979 of this issue, Allen et al. ( 4 ) and Baribi-Bartov et al. ( 5 ), respectively, report on the impact of misinformation on social media. Allen et al. find that Facebook c...
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作者：Brainard, Jeffrey
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作者：Carraro-Haddad, I.; Chafatinos, D. L.; Kuznetsov, A. S.; Papuccio-Fernandez, I. A.; Reynoso, A. A.; Bruchhausen, A.; Biermann, K.; Santos, P. V.; Usaj, G.; Fainstein, A.
作者单位：Comision Nacional de Energia Atomica (CNEA); Centro Atomico Bariloche; Comision Nacional de Energia Atomica (CNEA); University Nacional Cuyo Mendoza; Instituto Balseiro; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Leibniz Association; Paul Drude Institute for Solid State Electronics; University of Antwerp; Universite Libre de Bruxelles
摘要：Time crystals (TCs) are many-body systems that display spontaneous breaking of time translation symmetry. We demonstrate a TC by using driven-dissipative condensates of microcavity exciton-polaritons, spontaneously formed from an incoherent particle bath. The TC phases are controlled by the power of a continuous-wave nonresonant optical drive exciting the condensate and the interaction with cavity phonons. Those phases are, for increasing power, Larmor-like precession of the condensate pseudo-...
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作者：Czerski, Helen
作者单位：University of London; University College London
摘要：A journalist probes the challenges facing the global commons
