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作者：Ku, Angela F.; Sharma, Kiran L.; Ta, Hai Minh; Sutton, Courtney M.; Bohren, Kurt M.; Wang, Yong; Chamakuri, Srinivas; Chen, Ruihong; Hakenjos, John M.; Jimmidi, Ravikumar; Kent, Katarzyna; Li, Feng; Li, Jian-Yuan; Ma, Lang; Madasu, Chandrashekhar; Palaniappan, Murugesan; Palmer, Stephen S.; Qin, Xuan; Robers, Matthew B.; Sankaran, Banumathi; Tan, Zhi; Vasquez, Yasmin M.; Wang, Jian; Wilkinson, Jennifer; Yu, Zhifeng; Ye, Qiuji; Young, Damian W.; Teng, Mingxing; Kim, Choel; Matzuk, Martin M.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Promega Corporation; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Men or mice with homozygous serine/threonine kinase 33 (STK33) mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33 for male contraception with STK33-specific inhibitors, we screened our multibillion-compound collection of DNA-encoded chemical libraries, uncovered potent STK33-specific inhibitors, determined the STK33 kinase domain structure bound with a truncated hit CDD-2211, and generated an optimized hit CDD-2807 that demonstrates nanomolar c...
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作者：Qie, Boyu; Wang, Ziyi; Jiang, Jingwei; Zhang, Zisheng; Jacobse, Peter H.; Lu, Jiaming; Li, Xinheng; Liu, Fujia; Alexandrova, Anastassia N.; Louie, Steven G.; Crommie, Michael F.; Fischer, Felix R.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Berkeley
摘要：The covalent interaction of N-heterocyclic carbenes (NHCs) with transition metal atoms gives rise to distinctive frontier molecular orbitals (FMOs). These emergent electronic states have spurred the widespread adoption of NHC ligands in chemical catalysis and functional materials. Although formation of carbene-metal complexes in self-assembled monolayers on surfaces has been explored, design and electronic structure characterization of extended low-dimensional NHC-metal lattices remains elusiv...
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作者：Novarino, Gaia; Bock, Christoph
作者单位：Institute of Science & Technology - Austria; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Medical University of Vienna
摘要：DNA sequences are connected to genes and functions in the developing and adult brain
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作者：Enserink, Martin
摘要：Couple at Leiden University broke norms for 3 decades, investigators say
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作者：Holdaway, Jerrett; Georg, Gunda I.
作者单位：University of Minnesota System; University of Minnesota Twin Cities
摘要：An inhibitor of a nonhormonal target is identified using a DNA-encoded chemical library
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作者：Cornwall, Warren
摘要：After $50 million upgrade, U.S. research sub can reach 99% of the ocean floor
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作者：Wamsley, Brie; Bicks, Lucy; Cheng, Yuyan; Kawaguchi, Riki; Quintero, Diana; Margolis, Michael; Grundman, Jennifer; Liu, Jianyin; Xiao, Shaohua; Hawken, Natalie; Mazariegos, Samantha; Geschwind, Daniel H.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood. We performed deep single-nucleus RNA sequencing (snRNA-seq) to examine cell composition and transcriptomics, identifying dysregulation of cell type-specific gene regulatory networks (GRNs) in autism spectrum disorder (ASD), which we corroborated using sin...
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作者：Zhu, Shihan; Shen, Zeyu; Wu, Xiandeng; Han, Wenyan; Jia, Bowen; Lu, Wei; Zhang, Mingjie
作者单位：Hong Kong University of Science & Technology; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Southern University of Science & Technology
摘要：Excitatory and inhibitory synapses do not overlap even when formed on one submicron-sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or densities (e/iPSDs) are segregated is not understood. Broadly, why membraneless organelles are naturally segregated in cellular subcompartments is unclear. Using biochemical reconstitutions in vitro and in cells, we demonstrate that ePSDs and iPSDs spontaneously segregate into distinct condensed molecular assemblies through p...
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作者：Duan, Tianwei; You, Shuai; Chen, Min; Yu, Wenjian; Li, Yanyan; Guo, Peijun; Berry, Joseph J.; Luther, Joseph M.; Zhu, Kai; Zhou, Yuanyuan
作者单位：Hong Kong Baptist University; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; Yale University; Yale University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Hong Kong University of Science & Technology
摘要：Mechanical failure and chemical degradation of device heterointerfaces can strongly influence the long-term stability of perovskite solar cells (PSCs) under thermal cycling and damp heat conditions. We report chirality-mediated interfaces based on R-/S-methylbenzyl-ammonium between the perovskite absorber and electron-transport layer to create an elastic yet strong heterointerface with increased mechanical reliability. This interface harnesses enantiomer-controlled entropy to enhance tolerance...
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作者：Zaluar, Marina T.; Vale, Mariana M.; Alves, Maria Alice S.
作者单位：Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de Janeiro; Universidade do Estado do Rio de Janeiro
