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作者：Liao, Diana A.; Brecht, Katharina F.; Veit, Lena; Nieder, Andreas
作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen
摘要：Producing a specific number of vocalizations with purpose requires a sophisticated combination of numerical abilities and vocal control. Whether this capacity exists in animals other than humans is yet unknown. We show that crows can flexibly produce variable numbers of one to four vocalizations in response to arbitrary cues associated with numerical values. The acoustic features of the first vocalization of a sequence were predictive of the total number of vocalizations, indicating a planning...
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作者：Deng, Chengyu; Whalen, Sean; Steyert, Marilyn; Ziffra, Ryan; Przytycki, Pawel F.; Inoue, Fumitaka; Pereira, Daniela A.; Capauto, Davide; Norton, Scott; Vaccarino, Flora M.; Pollen, Alex A.; Nowakowski, Tomasz J.; Ahituv, Nadav; Pollard, Katherine S.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco; Kyoto University; Universidade Federal de Minas Gerais; Yale University; Yale University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 open chromatin regions, including thousands of sequences with cell type-specific accessibility and variants associated with brain gene regulation. In primary cells, we identified 46,802 active enhancer sequences and 1...
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作者：O'Callaghan, Jonathan
摘要：Apparent overabundance means theories of how galaxies took shape in the early universe may need adjusting
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作者：Patowary, Ashok; Zhang, Pan; Jops, Connor; Vuong, Celine K.; Ge, Xinzhou; Hou, Kangcheng; Kim, Minsoo; Gong, Naihua; Margolis, Michael; Vo, Daniel; Wang, Xusheng; Liu, Chunyu; Pasaniuc, Bogdan; Li, Jingyi Jessica; Gandal, Michael J.; de la Torre-Ubieta, Luis
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; State University of New York (SUNY) System; SUNY Upstate Medical University; Central South University; Central South University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
摘要：RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type-specific splicing and transcript-isoform diversity during human brain development has not been systematically investigated. In this work, we leveraged single-molecule long-read sequencing to deeply profile the full-length transcriptome of the germinal zone and cortical plate regions of the developing human neocortex at tissue and single-cell resolution. We identified 214...
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作者：Brainard, Jeffrey
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作者：Kaiser, Jocelyn
摘要：EcoHealth Alliance mishandled grant that helped fund virus studies in China, officials say
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作者：Cohen, Jon
摘要：Market uncertainties, safety rules, and export worries stand in way of H5N1 shots for cattle
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作者：Service, Robert F.
摘要：Automated labs spread across the globe create, test, and assemble materials-no humans required
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作者：Strieth-Kalthoff, Felix; Hao, Han; Rathore, Vandana; Derasp, Joshua; Gaudin, Theophile; Angello, Nicholas H.; Seifrid, Martin; Trushina, Ekaterina; Guy, Mason; Liu, Junliang; Tang, Xun; Mamada, Masashi; Wang, Wesley; Tsagaantsooj, Tuul; Lavigne, Cyrille; Pollice, Robert; Wu, Tony C.; Hotta, Kazuhiro; Bodo, Leticia; Li, Shangyu; Haddadnia, Mohammad; Wolos, Agnieszka; Roszak, Rafal; Ser, Cher Tian; Bozal-Ginesta, Carlota; Hickman, Riley J.; Vestfrid, Jenya; Aguilar-Granda, Andres; Klimareva, Elena L.; Sigerson, Ralph C.; Hou, Wenduan; Gahler, Daniel; Lach, Slawomir; Warzybok, Adrian; Borodin, Oleg; Rohrbach, Simon; Sanchez-Lengeling, Benjamin; Adachi, Chihaya; Grzybowski, Bartosz A.; Cronin, Leroy; Hein, Jason E.; Burke, Martin D.; Aspuru-Guzik, Alan
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of British Columbia; University of Illinois System; University of Illinois Urbana-Champaign; North Carolina State University; University of Glasgow; Kyushu University; Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Vector Institute for Artificial Intelligence; Polish Academy of Sciences; Institute of Organic Chemistry of the Polish Academy of Sciences; Institut de Recerca en Energia de Catalunya (IREC); Jagiellonian University; Alphabet Inc.; Google Incorporated; Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST); University of Bergen; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR)
摘要：Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based strategy that enabled delocalized and asynchronous design-make-test-analyze cycles. We showcased this approach through the exploration of molecular gain materials for organic solid-state lasers as a frontier application in molecular optoelectronics. ...
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作者：Alford, C. Fred
作者单位：University System of Maryland; University of Maryland College Park
