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作者:Fu, Hailin; Huang, Jingyi; van der Tol, Joost J. B.; Su, Lu; Wang, Yuyang; Dey, Swayandipta; Zijlstra, Peter; Fytas, George; Vantomme, Ghislaine; Dankers, Patricia Y. W.; Meijer, E. W.
作者单位:Eindhoven University of Technology; Eindhoven University of Technology; Eindhoven University of Technology; Eindhoven University of Technology; Eindhoven University of Technology; Leiden University; Leiden University - Excl LUMC; Eindhoven University of Technology; Eindhoven University of Technology; Max Planck Society; Foundation for Research & Technology - Hellas (FORTH); University of New South Wales Sydney; University of New South Wales Sydney
摘要:Liquid-liquid phase separation (LLPS) of biopolymers has recently been shown to play a central role in the formation of membraneless organelles with a multitude of biological functions1-3. The interplay between LLPS and macromolecular condensation is part of continuing studies4,5. Synthetic supramolecular polymers are the non-covalent equivalent of macromolecules but they are not reported to undergo LLPS yet. Here we show that continuously growing fibrils, obtained from supramolecular polymeri...
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作者:Qu, Zhan; Zhang, Zhenjun; Liu, Rui; Xu, Ling; Zhang, Yining; Li, Xiaotao; Zhao, Zhenkai; Duan, Qiqiang; Wang, Shaogang; Li, Shujun; Ma, Yingjie; Shao, Xiaohong; Yang, Rui; Eckert, Juergen; Ritchie, Robert O.; Zhang, Zhefeng
作者单位:Chinese Academy of Sciences; Institute of Metal Research, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shenyang Institute of Engineering; ShanghaiTech University; Austrian Academy of Sciences; University of Leoben; University of California System; University of California Berkeley
摘要:The advantage of 3D printing-that is, additive manufacturing (AM) of structural materials-has been severely compromised by their disappointing fatigue properties1,2. Commonly, poor fatigue properties appear to result from the presence of microvoids induced by current printing process procedures3,4. Accordingly, the question that we pose is whether the elimination of such microvoids can provide a feasible solution for marked enhancement of the fatigue resistance of void-free AM (Net-AM) alloys....
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作者:[Anonymous]
摘要:With renewal of the two countries' decades-long science pact still on hold, there is too much talk about the risks of collaboration - and too little about the benefits.
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作者:Davies, Surekha
摘要:Indigenous Americans' relationships with and knowledge of animals have influenced how Europeans have thought about animals since 1492.
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作者:Ziyatdinov, Andrey; Torres, Jason; Alegre-Diaz, Jesus; Backman, Joshua; Mbatchou, Joelle; Turner, Michael; Gaynor, Sheila M.; Joseph, Tyler; Zou, Yuxin; Liu, Daren; Wade, Rachel; Staples, Jeffrey; Panea, Razvan; Popov, Alex; Bai, Xiaodong; Balasubramanian, Suganthi; Habegger, Lukas; Lanche, Rouel; Lopez, Alex; Maxwell, Evan; Jones, Marcus; Garcia-Ortiz, Humberto; Ramirez-Reyes, Raul; Santacruz-Benitez, Rogelio; Nag, Abhishek; Smith, Katherine R.; Damask, Amy; Lin, Nan; Paulding, Charles; Reppell, Mark; Zollner, Sebastian; Jorgenson, Eric; Salerno, William; Petrovski, Slave; Overton, John; Reid, Jeffrey; Thornton, Timothy A.; Abecasis, Goncalo; Berumen, Jaime; Orozco-Orozco, Lorena; Collins, Rory; Baras, Aris; Hill, Michael R.; Emberson, Jonathan R.; Marchini, Jonathan; Kuri-Morales, Pablo; Tapia-Conyer, Roberto
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作者:Koyuncu, Seda; Loureiro, Rute; Lee, Hyun Ju; Wagle, Prerana; Krueger, Marcus; Vilchez, David
作者单位:University of Cologne; University of Cologne; University of Cologne
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作者:Lenharo, Mariana
摘要:Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
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作者:Ilik, Ibrahim Avsar; Glazar, Petar; Tse, Kevin; Braendl, Bjoern; Meierhofer, David; Muller, Franz-Josef; Smith, Zachary D.; Aktas, Tugce
作者单位:Max Planck Society; Yale University; University of Kiel; Schleswig Holstein University Hospital; Max Planck Society; Max Planck Society
摘要:Transposable elements (TEs) are a major constituent of human genes, occupying approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs are transcribed along with their host genes but rarely contribute to the final mRNA product because they are spliced out together with the intron and rapidly degraded. Paradoxically, TEs are an abundant source of RNA-processing signals through which they can create new introns1, and also functional2 or non-functional chimeric t...
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作者:Deng, Min; Yu, Jinhan; Blackmond, Donna G.
作者单位:Scripps Research Institute
摘要:The single chirality of biological molecules is a signature of life. Yet, rationalizing how single chirality emerged remains a challenging goal1. Research has commonly focused on initial symmetry breaking and subsequent enantioenrichment of monomer building blocks-sugars and amino acids-that compose the genetic polymers RNA and DNA as well as peptides. If these building blocks are only partially enantioenriched, however, stalling of chain growth may occur, whimsically termed in the case of nuc...
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作者:Powell, Diana; Feinstein, Adina D.; Lee, Elspeth K. H.; Zhang, Michael; Tsai, Shang-Min; Taylor, Jake; Kirk, James; Bell, Taylor; Barstow, Joanna K.; Gao, Peter; Bean, Jacob L.; Blecic, Jasmina; Chubb, Katy L.; Crossfield, Ian J. M.; Jordan, Sean; Kitzmann, Daniel; Moran, Sarah E.; Morello, Giuseppe; Moses, Julianne I.; Welbanks, Luis; Yang, Jeehyun; Zhang, Xi; Ahrer, Eva-Maria; Bello-Arufe, Aaron; Brande, Jonathan; Casewell, S. L.; Crouzet, Nicolas; Cubillos, Patricio E.; Demory, Brice-Olivier; Dyrek, Achrene; Flagg, Laura; Hu, Renyu; Inglis, Julie; Jones, Kathryn D.; Kreidberg, Laura; Lopez-Morales, Mercedes; Lagage, Pierre-Olivier; Meier Valdes, Erik A.; Miguel, Yamila; Parmentier, Vivien; Piette, Anjali A. A.; Rackham, Benjamin V.; Radica, Michael; Redfield, Seth; Stevenson, Kevin B.; Wakeford, Hannah R.; Aggarwal, Keshav; Alam, Munazza K.; Batalha, Natalie M.; Batalha, Natasha E.; Benneke, Bjoern; Berta-Thompson, Zach K.; Brady, Ryan P.; Caceres, Claudio; Carter, Aarynn L.; Desert, Jean-Michel; Harrington, Joseph; Iro, Nicolas; Line, Michael R.; Lothringer, Joshua D.; MacDonald, Ryan J.; Mancini, Luigi; Molaverdikhani, Karan; Mukherjee, Sagnick; Nixon, Matthew C.; Oza, Apurva V.; Palle, Enric; Rustamkulov, Zafar; Sing, David K.; Steinrueck, Maria E.; Venot, Olivia; Wheatley, Peter J.; Yurchenko, Sergei N.
作者单位:Smithsonian Institution; University of Chicago; University of Colorado System; University of Colorado Boulder; University of Bern; University of California System; University of California Riverside; University of Oxford; Universite de Montreal; Universite de Montreal; Imperial College London; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Open University - UK; Carnegie Institution for Science; New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi; University of St Andrews; University of Kansas; University of Cambridge; University of Arizona; Chalmers University of Technology; Instituto de Astrofisica de Canarias; Istituto Nazionale Astrofisica (INAF); Arizona State University; Arizona State University-Tempe; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of California System; University of California Santa Cruz; University of Warwick; University of Warwick; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Leicester; Leiden University; Leiden University - Excl LUMC; Istituto Nazionale Astrofisica (INAF); Austrian Academy of Sciences; University of Bern; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Cornell University; Cornell University; California Institute of Technology; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Observatoire de la Cote d'Azur; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Wesleyan University; Wesleyan University; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; University of Bristol; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Indore; University of California System; University of California Santa Cruz; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; University of Colorado System; University of Colorado Boulder; University of London; University College London; Universidad Andres Bello; University of Amsterdam; State University System of Florida; University of Central Florida; State University System of Florida; University of Central Florida; Helmholtz Association; German Aerospace Centre (DLR); Utah System of Higher Education; Utah Valley University; University of Michigan System; University of Michigan; University of Rome Tor Vergata; University of Munich; University System of Maryland; University of Maryland College Park; Johns Hopkins University; Johns Hopkins University; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Universite Paris-Est-Creteil-Val-de-Marne (UPEC)
摘要:The recent inference of sulfur dioxide (SO2) in the atmosphere of the hot (approximately 1,100K), Saturn-mass exoplanet WASP-39b from near-infrared JWST observations(1-3) suggests that photochemistry is a key process in high-temperature exoplanet atmospheres(4). This is because of the low (<1ppb) abundance of SO2 under thermochemical equilibrium compared with that produced from the photochemistry of H2O and H2S (1-10ppm)(4-9). However, the SO2 inference was made from a single, small molecular ...