-
作者：Murdock, Mitchell H.; Yang, Cheng-Yi; Sun, Na; Pao, Ping-Chieh; Blanco-Duque, Cristina; Kahn, Martin C.; Kim, TaeHyun; Lavoie, Nicolas S.; Victor, Matheus B.; Islam, Md Rezaul; Galiana, Fabiola; Leary, Noelle; Wang, Sidney; Bubnys, Adele; Ma, Emily; Akay, Leyla A.; Sneve, Madison; Qian, Yong; Lai, Cuixin; McCarthy, Michelle M.; Kopell, Nancy; Kellis, Manolis; Piatkevich, Kiryl D.; Boyden, Edward S.; Tsai, Li-Huei
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Westlake Laboratory; Westlake University; Westlake University; Boston University
摘要：The glymphatic movement of fluid through the brain removes metabolic waste(1-4). Noninvasive 40Hz stimulation promotes 40Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Alzheimer's disease(5-8). Here we show that multisensory gamma stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer's disease. Influx of cerebrospinal fluid was associated with increased aquaporin-...
-
作者：Witze, Alexandra
-
作者：[Anonymous]
-
作者：[Anonymous]
-
作者：[Anonymous]
-
作者：Franch, Melissa; Yellapantula, Sudha; Parajuli, Arun; Kharas, Natasha; Wright, Anthony; Aazhang, Behnaam; Dragoi, Valentin
作者单位：University of Texas System; University of Texas Health Science Center Houston; Rice University; Rice University; Houston Methodist
摘要：Social interactions represent a ubiquitous aspect of our everyday life that we acquire by interpreting and responding to visual cues from conspecifics(1). However, despite the general acceptance of this view, how visual information is used to guide the decision to cooperate is unknown. Here, we wirelessly recorded the spiking activity of populations of neurons in the visual and prefrontal cortex in conjunction with wireless recordings of oculomotor events while freely moving macaques engaged i...
-
作者：Ledford, Heidi
-
作者：Yamagishi, Makoto; Kuze, Yuta; Kobayashi, Seiichiro; Nakashima, Makoto; Morishima, Satoko; Kawamata, Toyotaka; Makiyama, Junya; Suzuki, Kako; Seki, Masahide; Abe, Kazumi; Imamura, Kiyomi; Watanabe, Eri; Tsuchiya, Kazumi; Yasumatsu, Isao; Takayama, Gensuke; Hizukuri, Yoshiyuki; Ito, Kazumi; Taira, Yukihiro; Nannya, Yasuhito; Tojo, Arinobu; Watanabe, Toshiki; Tsutsumi, Shinji; Suzuki, Yutaka; Uchimaru, Kaoru
作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; University of the Ryukyus; University of Tokyo; University of Tokyo; Daiichi Sankyo Company Limited; Daiichi Sankyo Company Limited; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Saint Marianna University
摘要：Epigenomes enable the rectification of disordered cancer gene expression, thereby providing new targets for pharmacological interventions. The clinical utility of targeting histone H3 lysine trimethylation (H3K27me3) as an epigenetic hallmark has been demonstrated(1-7). However, in actual therapeutic settings, the mechanism by which H3K27me3-targeting therapies exert their effects and the response of tumour cells remain unclear. Here we show the potency and mechanisms of action and resistance ...
-
作者：Bally, John
作者单位：University of Colorado System; University of Colorado Boulder
摘要：Astrophysicist whose radio-wave observations confirmed the Big Bang origin of the Universe. Astrophysicist whose radio-wave observations confirmed the Big Bang origin of the Universe.
-
作者：Lipp, Benjamin
作者单位：Technical University of Denmark
