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作者:Li, Yang; Gewin, Virginia
作者单位:Peking University
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作者:Patta, Indumathi; Zand, Maryam; Lee, Lindsay; Mishra, Shreya; Bortnick, Alexandra; Lu, Hanbin; Prusty, Arpita; McArdle, Sara; Mikulski, Zbigniew; Wang, Huan-You; Cheng, Christine S.; Fisch, Kathleen M.; Hu, Ming; Murre, Cornelis
作者单位:University of California System; University of California San Diego; University of California System; University of California San Diego; Cleveland Clinic Foundation; La Jolla Institute for Immunology; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces(1-3). However, how polymorphonuclear structures are assembled remains unknown(4). Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin(5)-leads to the assembly of polymorphonuclear genomes. Specifically, we found that in mononuclear neutrophil progenitors, acute depletion of ...
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作者:Gewin, Virginia; Li, Yang
作者单位:Peking University
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作者:Messeri, Lisa; Crockett, M. J.
作者单位:Yale University; Princeton University; Princeton University
摘要:Scientists are enthusiastically imagining ways in which artificial intelligence (AI) tools might improve research. Why are AI tools so attractive and what are the risks of implementing them across the research pipeline? Here we develop a taxonomy of scientists' visions for AI, observing that their appeal comes from promises to improve productivity and objectivity by overcoming human shortcomings. But proposed AI solutions can also exploit our cognitive limitations, making us vulnerable to illu...
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作者:Kulkarni, Sumeet
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作者:Reardon, Sara
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作者:Le Verge-Serandour, Mathieu; Alim, Karen
作者单位:Technical University of Munich
摘要:Networks filled with self-propelled fluids display meandering patterns that have been shown to follow rules similar to those of sudoku puzzles - offering design principles for microfluidic devices, and the possibility of 'active fluid' logic.
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作者:Mallapaty, Smriti; Tollefson, Jeff; Wong, Carissa; Wild, Sarah; Gaind, Nisha
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作者:[Anonymous]
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作者:Maiolino, Roberto; Scholtz, Jan; Witstok, Joris; Carniani, Stefano; D'Eugenio, Francesco; de Graaff, Anna; Uebler, Hannah; Tacchella, Sandro; Curtis-Lake, Emma; Arribas, Santiago; Bunker, Andrew; Charlot, Stephane; Chevallard, Jacopo; Curti, Mirko; Looser, Tobias J.; Maseda, Michael V.; Rawle, Timothy D.; del Pino, Bruno Rodriguez; Willott, Chris J.; Egami, Eiichi; Eisenstein, Daniel J.; Hainline, Kevin N.; Robertson, Brant; Williams, Christina C.; Willmer, Christopher N. A.; Baker, William M.; Boyett, Kristan; DeCoursey, Christa; Fabian, Andrew C.; Helton, Jakob M.; Ji, Zhiyuan; Jones, Gareth C.; Kumari, Nimisha; Laporte, Nicolas; Nelson, Erica J.; Perna, Michele; Sandles, Lester; Shivaei, Irene; Sun, Fengwu
作者单位:University of Cambridge; University of Cambridge; University of London; University College London; Scuola Normale Superiore di Pisa; Max Planck Society; University of Hertfordshire; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Astrobiologia (INTA); University of Oxford; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); European Southern Observatory; University of Wisconsin System; University of Wisconsin Madison; Space Telescope Science Institute; National Research Council Canada; University of Arizona; Smithsonian Institution; University of California System; University of California Santa Cruz; University of Melbourne; University of Cambridge; Space Telescope Science Institute; University of Colorado System; University of Colorado Boulder
摘要:Several theories have been proposed to describe the formation of black hole seeds in the early Universe and to explain the emergence of very massive black holes observed in the first thousand million years after the Big Bang(1-3). Models consider different seeding and accretion scenarios(4-7), which require the detection and characterization of black holes in the first few hundred million years after the Big Bang to be validated. Here we present an extensive analysis of the JWST-NIRSpec spectr...