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作者：Smyth, Leon C. D.; Xu, Di; Okar, Serhat V.; Dykstra, Taitea; Rustenhoven, Justin; Papadopoulos, Zachary; Bhasiin, Kesshni; Kim, Min Woo; Drieu, Antoine; Mamuladze, Tornike; Blackburn, Susan; Gu, Xingxing; Gaitan, Maria I.; Nair, Govind; Storck, Steffen E.; Du, Siling; White, Michael A.; Bayguinov, Peter; Smirnov, Igor; Dikranian, Krikor; Reich, Daniel S.; Kipnis, Jonathan
作者单位：Washington University (WUSTL); Washington University (WUSTL); National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of Auckland; University of Auckland; Washington University (WUSTL); Washington University (WUSTL); National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：The arachnoid barrier delineates the border between the central nervous system and dura mater. Although the arachnoid barrier creates a partition, communication between the central nervous system and the dura mater is crucial for waste clearance and immune surveillance(1,2). How the arachnoid barrier balances separation and communication is poorly understood. Here, using transcriptomic data, we developed transgenic mice to examine specific anatomical structures that function as routes across t...
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作者：Asrar, Farhan M.; Siddiqui, Safa; Yi, Soyeon
作者单位：University of Toronto
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作者：Prillaman, Mckenzie
摘要：Large language models are transforming scientific writing and publishing. But the productivity boost that these tools bring could have a downside.
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作者：Vijg, Jan; Hoeijmakers, Jan
作者单位：Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Erasmus University Rotterdam; Erasmus MC
摘要：Researcher who established the role of cellular senescence in cancer and ageing.
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作者：Adams, D. J.; Barlas, B.; McIntyre, R. E.; Salguero, I.; van der Weyden, L.; Barros, A.; Vicente, J. R.; Karimpour, N.; Haider, A.; Ranzani, M.; Turner, G.; Thompson, N. A.; Harle, V.; Olvera-Leon, R.; Robles-Espinoza, C. D.; Speak, A. O.; Geisler, N.; Weninger, W. J.; Geyer, S. H.; Hewinson, J.; Karp, N. A.; Fu, B.; Yang, F.; Kozik, Z.; Choudhary, J.; Yu, L.; van Ruiten, M. S.; Rowland, B. D.; Lelliott, C. J.; Velasco-Herrera, M. del Castillo; Verstraten, R.; Bruckner, L.; Henssen, A. G.; Rooimans, M. A.; de lange, J.; Mohun, T. J.; Arends, M. J.; Kentistou, K. A.; Coelho, P. A.; Zhao, Y.; Zecchini, H.; Perry, J. R. B.; Jackson, S. P.; Balmus, G.
作者单位：Wellcome Trust Sanger Institute; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Universidad Nacional Autonoma de Mexico; Medical University of Vienna; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Netherlands Cancer Institute; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); University of Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; Vrije Universiteit Amsterdam; MRC National Institute for Medical Research; University of Edinburgh; University of Cambridge; University of Cambridge; University of Cambridge; Cancer Research UK; CRUK Cambridge Institute
摘要：Genomic instability arising from defective responses to DNA damage(1) or mitotic chromosomal imbalances(2) can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and diseases associated with genomic instability, the catalogue of genetic players that regulate the generation of MN remains to be determined. Here we analyse 997 mouse mutant lines, revealing 145 genes whose loss significantly increases (n = 71) or decre...
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作者：Liu, Xiaoyu; Shi, Yiting; Liu, Rui; Song, Kangcheng; Chen, Lei
作者单位：Peking University; Peking University; Peking University; Peking University
摘要：Phagocyte NADPH oxidase, a protein complex with a core made up of NOX2 and p22 subunits, is responsible for transferring electrons from intracellular NADPH to extracellular oxygen(1). This process generates superoxide anions that are vital for killing pathogens(1). The activation of phagocyte NADPH oxidase requires membrane translocation and the binding of several cytosolic factors(2). However, the exact mechanism by which cytosolic factors bind to and activate NOX2 is not well understood. Her...
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作者：Coombs, Amy
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作者：Velazquez, Jose Luis Perez
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作者：He, Xianjin; Abramoff, Rose Z.; Abs, Elsa; Georgiou, Katerina; Zhang, Haicheng; Goll, Daniel S.
作者单位：CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Sun Yat Sen University
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作者：Sigmund, Karl
作者单位：University of Vienna
