作者：Anderson, Kermyt G.
作者单位：University of Oklahoma System; University of Oklahoma - Norman
摘要：An exploration of the evolution of male nurturing shows why, unlike fathers among other great apes, human dads are biologically wired to be hands-on parents.
作者：Okur, Zeynep; Schlauri, Nadia; Bitsikas, Vassilis; Panopoulou, Myrto; Ortiz, Raul; Schwaiger, Michaela; Karmakar, Kajari; Schreiner, Dietmar; Scheiffele, Peter
作者单位：University of Basel; Swiss Institute of Bioinformatics; Friedrich Miescher Institute for Biomedical Research; University of Basel; Roche Holding
摘要：Throughout life, neuronal networks in the mammalian neocortex maintain a balance of excitation and inhibition, which is essential for neuronal computation 1,2 . Deviations from a balanced state have been linked to neurodevelopmental disorders, and severe disruptions result in epilepsy 3-5 . To maintain balance, neuronal microcircuits composed of excitatory and inhibitory neurons sense alterations in neural activity and adjust neuronal connectivity and function. Here we identify a signalling pa...
作者：Braxton, Alicia M.; Kiemen, Ashley L.; Grahn, Mia P.; Forjaz, Andre; Parksong, Jeeun; Babu, Jaanvi Mahesh; Lai, Jiaying; Zheng, Lily; Niknafs, Noushin; Jiang, Liping; Cheng, Haixia; Song, Qianqian; Reichel, Rebecca; Graham, Sarah; Damanakis, Alexander I.; Fischer, Catherine G.; Mou, Stephanie; Metz, Cameron; Granger, Julie; Liu, Xiao-Ding; Bachmann, Niklas; Zhu, Yutong; Liu, YunZhou; Almagro-Perez, Cristina; Jiang, Ann Chenyu; Yoo, Jeonghyun; Kim, Bridgette; Du, Scott; Foster, Eli; Hsu, Jocelyn Y.; Rivera, Paula Andreu; Chu, Linda C.; Liu, Fengze; Fishman, Elliot K.; Yuille, Alan; Roberts, Nicholas J.; Thompson, Elizabeth D.; Scharpf, Robert B.; Cornish, Toby C.; Jiao, Yuchen; Karchin, Rachel; Hruban, Ralph H.; Wu, Pei-Hsun; Wirtz, Denis; Wood, Laura D.
作者单位：Johns Hopkins University; Medical University of South Carolina; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Johns Hopkins University; Johns Hopkins University; University of Colorado System; University of Colorado Anschutz Medical Campus; Henan Academy of Innovations in Medical Science; Johns Hopkins University
摘要：Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of pancreatic cancer, but their small size and inaccessibility in humans make them challenging to study(1). Critically, the number, dimensions and connectivity of human PanINs remain largely unknown, precluding important insights into early cancer development. Here, we provide a microanatomical survey of human PanINs by analysing 46 large samples of grossly normal human pancreas with a machine-learning pipeline for q...
作者：Gibney, Elizabeth
摘要：Timekeepers based on energy shifts in atomic nuclei could transform fundamental-physics research.
作者：Weis, Jakob; Chase, Zanna; Schallenberg, Christina; Strutton, Peter G.; Bowie, Andrew R.; Fiddes, Sonya L.
作者单位：University of Tasmania; University of Tasmania; University of Tasmania; University of Tasmania; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment
摘要：Natural iron fertilization of the Southern Ocean by windblown dust has been suggested to enhance biological productivity and modulate the climate(1-3). Yet, this process has never been quantified across the Southern Ocean and at annual timescales(4,5). Here we combined 11years of nitrate observations from autonomous biogeochemical ocean profiling floats with a Southern Hemisphere dust simulation to empirically derive the relationship between dust-iron deposition and annual net community produc...
作者：Classen, Anne-Kathrin
作者单位：University of Freiburg; University of Freiburg
摘要：Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA.
