-
作者：Liang, Chih-Chao; Greenhough, Luke A.; Masino, Laura; Maslen, Sarah; Bajrami, Ilirjana; Tuppi, Marcel; Skehel, Mark; Taylor, Ian A.; West, Stephen C.
作者单位：Francis Crick Institute
摘要：RAD52 is important for the repair of DNA double-stranded breaks(1,2), mitotic DNA synthesis(3-5) and alternative telomere length maintenance(6,7). Central to these functions, RAD52 promotes the annealing of complementary single-stranded DNA (ssDNA)(8,9) and provides an alternative to BRCA2/RAD51-dependent homologous recombination repair(10). Inactivation of RAD52 in homologous-recombination-deficient BRCA1- or BRCA2-defective cells is synthetically lethal(11,12), and aberrant expression of RAD...
-
作者：Wong, Carissa
-
作者：Allan, Oscar
-
作者：De Ambrosio, Martin; Koop, Fermin
摘要：President Javier Milei is making moves to partially privatize the sector, but in the meantime, projects have paused.
-
作者：Veerus, Liisa; Blaser, Martin J.
作者单位：Rutgers University System; Rutgers University New Brunswick
摘要：Altering gut bacteria in male mice revealed that microorganisms are needed for normal sperm development and offspring health. Scientists discuss the implications in terms of understanding microbes, male fertility and pregnancy.
-
作者：Parreno, V.; Loubiere, V.; Schuettengruber, B.; Fritsch, L.; Rawal, C. C.; Erokhin, M.; Gyorffy, B.; Normanno, D.; Di Stefano, M.; Moreaux, J.; Butova, N. L.; Chiolo, I.; Chetverina, D.; Martinez, A-M; Cavalli, G.
作者单位：Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of Southern California; Russian Academy of Sciences; Institute of Gene Biology (IGB) of Russian Academy of Sciences; Semmelweis University; University of Pecs; Universite de Montpellier; CHU de Montpellier; Universite de Montpellier
摘要：Although cancer initiation and progression are generally associated with the accumulation of somatic mutations(1,2), substantial epigenomic alterations underlie many aspects of tumorigenesis and cancer susceptibility(36) , suggesting that genetic mechanisms might not be the only drivers of malignant transformation(7). However, whether purely non-genetic mechanisms are sufcient to initiate tumorigenesis irrespective of mutations has been unknown. Here, we show that a transient perturbation of t...
-
作者：Swain, Anshuman; Woodhouse, Adam; Fagan, William F.; Fraass, Andrew J.; Lowery, Christopher M.
作者单位：Harvard University; Harvard University; Smithsonian Institution; Smithsonian National Museum of Natural History; University System of Maryland; University of Maryland College Park; University of Texas System; University of Texas Austin; University of Bristol; University of Victoria
摘要：In palaeontological studies, groups with consistent ecological and morphological traits across a clade's history (functional groups)(1) afford different perspectives on biodiversity dynamics than do species and genera(2,3), which are evolutionarily ephemeral. Here we analyse Triton, a global dataset of Cenozoic macroperforate planktonic foraminiferal occurrences(4), to contextualize changes in latitudinal equitability gradients(1), functional diversity, palaeolatitudinal specialization and com...
-
作者：Karamlou, Amir H.; Rosen, Ilan T.; Muschinske, Sarah E.; Barrett, Cora N.; Di Paolo, Agustin; Ding, Leon; Harrington, Patrick M.; Hays, Max; Das, Rabindra; Kim, David K.; Niedzielski, Bethany M.; Schuldt, Meghan; Serniak, Kyle; Schwartz, Mollie E.; Yoder, Jonilyn L.; Gustavsson, Simon; Yanay, Yariv; Grover, Jeffrey A.; Oliver, William D.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Wellesley College; Massachusetts Institute of Technology (MIT); Lincoln Laboratory
摘要：Entanglement and its propagation are central to understanding many physical properties of quantum systems(1-3). Notably, within closed quantum many-body systems, entanglement is believed to yield emergent thermodynamic behaviour(4-7). However, a universal understanding remains challenging owing to the non-integrability and computational intractability of most large-scale quantum systems. Quantum hardware platforms provide a means to study the formation and scaling of entanglement in interactin...
-
作者：Reardon, Sara
摘要：Scientists worry that the H5N1 strain of avian influenza will become endemic in cattle, which would aid its spread in people.
-
作者：Kozlov, Max
摘要：New policy on high-risk biology studies aims to address criticism that previous rules were too vague.
