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作者：Son, Yeeun; Kenny, Timothy C.; Khan, Artem; Birsoy, Kivanc; Hite, Richard K.
作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Rockefeller University
摘要：Phosphatidylcholine and phosphatidylethanolamine, the two most abundant phospholipids in mammalian cells, are synthesized de novo by the Kennedy pathway from choline and ethanolamine, respectively(1-6). Despite the essential roles of these lipids, the mechanisms that enable the cellular uptake of choline and ethanolamine remain unknown. Here we show that the protein encoded by FLVCR1, whose mutation leads to the neurodegenerative syndrome posterior column ataxia and retinitis pigmentosa(7-9), ...
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作者：Zindl, Carlene L.; Wilson, C. Garrett; Chadha, Awalpreet S.; Duck, Lennard W.; Cai, Baiyi; Harbour, Stacey N.; Nagaoka-Kamata, Yoshiko; Hatton, Robin D.; Gao, Min; Figge, David A.; Weaver, Casey T.
作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
摘要：Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier(1-3). T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is required for the protection of colonic crypts against invasion during infection by the enteropathogen Citrobacter rodentium(4) (Cr). However, the intestinal epithelial cell (IEC) subsets targeted by T cell-derived IL-22, and how T cell-derived IL-22 sustains activation in IECs, remain unde...
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作者：[Anonymous]
摘要：Rich nations' fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.
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作者：Radko-Juettner, Sandi; Yue, Hong; Myers, Jacquelyn A.; Carter, Raymond D.; Robertson, Alexis N.; Mittal, Priya; Zhu, Zhexin; Hansen, Baranda S.; Donovan, Katherine A.; Hunkeler, Moritz; Rosikiewicz, Wojciech; Wu, Zhiping; Mcreynolds, Meghan G.; Burman, Shourya S. Roy; Schmoker, Anna M.; Mageed, Nada; Brown, Scott A.; Mobley, Robert J.; Partridge, Janet F.; Stewart, Elizabeth A.; Pruett-Miller, Shondra M.; Nabet, Behnam; Peng, Junmin; Gray, Nathanael S.; Fischer, Eric S.; Roberts, Charles W. M.
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作者：Brlik, Vojtech
作者单位：Charles University Prague
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作者：Shafir, Eldar
作者单位：Princeton University
摘要：Nobel prizewinner whose insights into the foibles of human decision-making launched the field of behavioural economics and sent ripples through all social sciences.
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作者：[Anonymous]
摘要：If Europe wants to create a high-risk, high-reward research body, it needs grass-roots backing.
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作者：Firmin, Julie; Ecker, Nicolas; Danon, Diane Rivet; Oezguec, Oezge; Barraud Lange, Virginie; Turlier, Herve; Patrat, Catherine; Maitre, Jean-Leon
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; College de France; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite
摘要：The shaping of human embryos begins with compaction, during which cells come into close contact1,2. Assisted reproductive technology studies indicate that human embryos fail compaction primarily because of defective adhesion3,4. On the basis of our current understanding of animal morphogenesis5,6, other morphogenetic engines, such as cell contractility, could be involved in shaping human embryos. However, the molecular, cellular and physical mechanisms driving human embryo morphogenesis remain...
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作者：Zhang, Xiangjie; Yan, Tao; Hou, Huaming; Yin, Junqing; Wan, Hongliu; Sun, Xiaodong; Zhang, Qing; Sun, Fanfei; Wei, Yao; Dong, Mei; Fan, Weibin; Wang, Jianguo; Sun, Yujie; Zhou, Xiong; Wu, Kai; Yang, Yong; Li, Yongwang; Cao, Zhi
作者单位：Chinese Academy of Sciences; Institute of Coal Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chengdu University; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; University System of Ohio; University of Cincinnati; Chinese Academy of Sciences; Peking University
摘要：Hydroformylation is an industrial process for the production of aldehydes from alkenes(1,2). Regioselective hydroformylation of propene to high-value n-butanal is particularly important, owing to a wide range of bulk applications of n-butanal in the manufacture of various necessities in human daily life(3). Supported rhodium (Rh) hydroformylation catalysts, which often excel in catalyst recyclability, ease of separation and adaptability for continuous-flow processes, have been greatly exploite...
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作者：Liu, Jian-Long; Luo, Xi-Yu; Yu, Yong; Wang, Chao-Yang; Wang, Bin; Hu, Yi; Li, Jun; Zheng, Ming-Yang; Yao, Bo; Yan, Zi; Teng, Da; Jiang, Jin-Wei; Liu, Xiao-Bing; Xie, Xiu-Ping; Zhang, Jun; Mao, Qing-He; Jiang, Xiao; Zhang, Qiang; Bao, Xiao-Hui; Pan, Jian-Wei
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; CAS Center for Excellence in Quantum Information & Quantum Physics; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Delft University of Technology
摘要：Towards realizing the future quantum internet(1,2), a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive multi-node set-ups on large scales. Here we report the creation of memory-memory entanglement in a multi-node quantum network over a metropolitan area. We use three independent memory nodes, each of which is equipped with an atomic ensemble quantum memory(3) that has telecom conversion, together with a photonic se...
