作者：Holderfield, Matthew; Lee, Bianca J.; Jiang, Jingjing; Tomlinson, Aidan; Seamon, Kyle J.; Mira, Alessia; Patrucco, Enrico; Goodhart, Grace; Dilly, Julien; Gindin, Yevgeniy; Dinglasan, Nuntana; Wang, Yingyun; Lai, Lick Pui; Cai, Shurui; Jiang, Lingyan; Nasholm, Nicole; Shifrin, Nataliya; Blaj, Cristina; Shah, Harshit; Evans, James W.; Montazer, Nilufar; Lai, Oliver; Shi, Jade; Ahler, Ethan; Quintana, Elsa; Chang, Stephanie; Salvador, Anthony; Marquez, Abby; Cregg, Jim; Liu, Yang; Milin, Anthony; Chen, Anqi; Ziv, Tamar Bar; Parsons, Dylan; Knox, John E.; Klomp, Jennifer E.; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Cuevas-Navarro, Antonio; Hu, Feng; Lito, Piro; Santamaria, David; Aguirre, Andrew J.; Waters, Andrew M.; Der, Channing J.; Ambrogio, Chiara; Wang, Zhengping; Gill, Adrian L.; Koltun, Elena S.; Smith, Jacqueline A. M.; Wildes, David; Singh, Mallika
作者单位：University of Turin; University System of Ohio; University of Cincinnati; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of North Carolina; University of North Carolina Chapel Hill; University System of Ohio; University of Cincinnati
摘要：RAS oncogenes (collectively NRAS, HRAS and especially KRAS) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61(1). Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients with multiple cancer types and have led to regulatory approvals for the treatment of non-small cell lung cancer(2,3). Nevertheless, KRAS(G12C) mutations account for only around 15% of KRAS-mutated cancers(4,5), a...
作者：Liu, Ao; Kim, Yong-Sung; Kim, Min Gyu; Reo, Youjin; Zou, Taoyu; Choi, Taesu; Bai, Sai; Zhu, Huihui; Noh, Yong-Young
作者单位：University of Electronic Science & Technology of China; Pohang University of Science & Technology (POSTECH); Northwestern University; Korea Research Institute of Standards & Science (KRISS); University of Science & Technology (UST); Pohang University of Science & Technology (POSTECH); University of Electronic Science & Technology of China
摘要：Compared to polycrystalline semiconductors, amorphous semiconductors offer inherent cost-effective, simple and uniform manufacturing. Traditional amorphous hydrogenated Si falls short in electrical properties, necessitating the exploration of new materials. The creation of high-mobility amorphous n-type metal oxides, such as a-InGaZnO (ref. 1), and their integration into thin-film transistors (TFTs) have propelled advancements in modern large-area electronics and new-generation displays(2-8). ...
作者：Casassus, Barbara
摘要：The contest to elect the next president of Paris-Saclay University has collapsed, reflecting wider issues at the giant research centre.
作者：Wang, Ya-Kun; Wan, Haoyue; Teale, Sam; Grater, Luke; Zhao, Feng; Zhang, Zhongda; Duan, Hong-Wei; Imran, Muhammad; Wang, Sui-Dong; Hoogland, Sjoerd; Liao, Liang-Sheng
作者单位：Soochow University - China; University of Toronto; University of Oxford
摘要：Light-emitting diodes (LEDs) based on perovskite quantum dots (QDs) have produced external quantum efficiencies (EQEs) of more than 25% with narrowband emission(1,2), but these LEDs have limited operating lifetimes. We posit that poor long-range ordering in perovskite QD films-variations in dot size, surface ligand density and dot-to-dot stacking-inhibits carrier injection, resulting in inferior operating stability because of the large bias required to produce emission in these LEDs. Here we r...
作者：Fink, Thomas
摘要：Cheap data and the absence of coincidences make maths an ideal testing ground for AI-assisted discovery - but only humans will be able to tell good conjectures from bad ones.
作者：Evans, Chantell S.
作者单位：Duke University; Howard Hughes Medical Institute
摘要：Organelles called mitochondria are transferred to blood-vessel-forming cells by support cells. Unexpectedly, these mitochondria are degraded, kick-starting the production of new ones and boosting vessel formation.
