2024

最新文章

• SCHEMES SELLING FAKE CITATIONS ALARM SCIENTISTS AI翻译
  作者：Chawla, Dalmeet Singh
• Neural circuit basis of placebo pain relief AI翻译
  作者：Chen, Chong; Niehaus, Jesse K.; Dinc, Fatih; Huang, Karen L.; Barnette, Alexander L.; Tassou, Adrien; Shuster, S. Andrew; Wang, Lihua; Lemire, Andrew; Menon, Vilas; Ritola, Kimberly; Hantman, Adam W.; Zeng, Hongkui; Schnitzer, Mark J.; Scherrer, Gregory
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Stanford University; Stanford University; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Columbia University; Allen Institute for Brain Science; Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：Placebo effects are notable demonstrations of mind-body interactions(1,2). During pain perception, in the absence of any treatment, an expectation of pain relief can reduce the experience of pain-a phenomenon known as placebo analgesia(3-6). However, despite the strength of placebo effects and their impact on everyday human experience and the failure of clinical trials for new therapeutics(7), the neural circuit basis of placebo effects has remained unclear. Here we show that analgesia from th...
• A second space age spanning omics, platforms and medicine across orbits AI翻译
  作者：Mason, Christopher E.; Green, James; Adamopoulos, Konstantinos I.; Afshin, Evan E.; Baechle, Jordan J.; Basner, Mathias; Bailey, Susan M.; Bielski, Luca; Borg, Josef; Borg, Joseph; Broddrick, Jared T.; Burke, Marissa; Caicedo, Andres; Castaneda, Veronica; Chatterjee, Subhamoy; Chin, Christopher R.; Church, George; Costes, Sylvain V.; De Vlaminck, Iwijn; Desai, Rajeev I.; Dhir, Raja; Diaz, Juan Esteban; Etlin, Sofia M.; Feinstein, Zachary; Furman, David; Garcia-Medina, J. Sebastian; Garrett-Bakelman, Francine; Giacomello, Stefania; Gupta, Anjali; Hassanin, Amira; Houerbi, Nadia; Irby, Iris; Javorsky, Emilia; Jirak, Peter; Jones, Christopher W.; Kamal, Khaled Y.; Kangas, Brian D.; Karouia, Fathi; Kim, Jangkeun; Kim, Joo Hyun; Kleinman, Ashley S.; Lam, Try; Lawler, John M.; Lee, Jessica A.; Limoli, Charles L.; Lucaci, Alexander; Mackay, Matthew; Mcdonald, J. Tyson; Melnick, Ari M.; Meydan, Cem; Mieczkowski, Jakub; Muratani, Masafumi; Najjar, Deena; Othman, Mariam A.; Overbey, Eliah G.; Paar, Vera; Park, Jiwoon; Paul, Amber M.; Perdyan, Adrian; Proszynski, Jacqueline; Reynolds, Robert J.; Ronca, April E.; Rubins, Kate; Ryon, Krista A.; Sanders, Lauren M.; Glowe, Patricia Savi; Shevde, Yash; Schmidt, Michael A.; Scott, Ryan T.; Shirah, Bader; Sienkiewicz, Karolina; Sierra, Maria A.; Siew, Keith; Theriot, Corey A.; Tierney, Braden T.; Venkateswaran, Kasthuri; Hirschberg, Jeremy Wain; Walsh, Stephen B.; Walter, Claire; Winer, Daniel A.; Yu, Min; Zea, Luis; Mateus, Jaime; Beheshti, Afshin
  作者单位：Cornell University; Weill Cornell Medicine; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; National Technical University of Athens; Buck Institute for Research on Aging; University of Pennsylvania; Colorado State University System; Colorado State University Fort Collins; University of Malta; University of Malta; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Embry-Riddle Aeronautical University; Universidad San Francisco de Quito; Universidad San Francisco de Quito; Universidad San Francisco de Quito; Universidad de los Andes - Chile; Universidad de los Andes - Chile; Southwest Research Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Zurich; Swiss Institute of Allergy & Asthma Research; Universidad San Francisco de Quito; Cornell University; Buck Institute for Research on Aging; Stanford University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Austral University; Royal Institute of Technology; Egyptian Knowledge Bank (EKB); Zagazig University; University System of Georgia; Georgia Institute of Technology; Harvard University; Paracelsus Private Medical University; Texas A&M University System; Texas A&M University College Station; Iowa State University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Baylor College of Medicine; University of Colorado System; University of Colorado Boulder; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of California System; University of California Irvine; Georgetown University; Fahrenheit Universities; Medical University Gdansk; University of Tsukuba; Cornell University; Weill Cornell Medicine; Paracelsus Private Medical University; Stanford University; University of Texas System; University of Texas Medical Branch Galveston; Wake Forest University; Wake Forest Baptist Medical Center; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; King Faisal Specialist Hospital & Research Center; University of London; University College London; University of Southern California; University of Toronto; University of Toronto; University Health Network Toronto; University of Toronto; University System of Maryland; University of Maryland Baltimore; University of Southern California; University of Colorado System; University of Colorado Boulder; SpaceX; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tool...
• A nebular origin for the persistent radio emission of fast radio bursts AI翻译
  作者：Bruni, Gabriele; Piro, Luigi; Yang, Yuan-Pei; Quai, Salvatore; Zhang, Bing; Palazzi, Eliana; Nicastro, Luciano; Feruglio, Chiara; Tripodi, Roberta; O'Connor, Brendan; Gardini, Angela; Savaglio, Sandra; Rossi, Andrea; Guelbenzu, Ana M. Nicuesa; Paladino, Rosita
  作者单位：Istituto Nazionale Astrofisica (INAF); Yunnan University; Purple Mountain Observatory, CAS; Chinese Academy of Sciences; Nanjing Institute of Astronomical Optics & Technology, NAOC, CAS; University of Bologna; Istituto Nazionale Astrofisica (INAF); Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Istituto Nazionale Astrofisica (INAF); University of Trieste; Carnegie Mellon University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Astrofisica de Andalucia (IAA); University of Calabria; Istituto Nazionale di Fisica Nucleare (INFN)
  摘要：Fast radio bursts (FRBs) are millisecond-duration, bright (approximately Jy) extragalactic bursts, whose production mechanism is still unclear(1). Recently, two repeating FRBs were found to have a physically associated persistent radio source of non-thermal origin(2,3). These two FRBs have unusually large Faraday rotation measure values(2,3), probably tracing a dense magneto-ionic medium, consistent with synchrotron radiation originating from a nebula surrounding the FRB source(4-8). Recent th...
• INFLAMMATORY BOWEL DISEASE'S MYSTERIES ARE BEING CRACKED AI翻译
  作者：Ledford, Heidi
• Neural general circulation models for weather and climate AI翻译
  作者：Kochkov, Dmitrii; Yuval, Janni; Langmore, Ian; Norgaard, Peter; Smith, Jamie; Mooers, Griffin; Klower, Milan; Lottes, James; Rasp, Stephan; Duben, Peter; Hatfield, Sam; Battaglia, Peter; Sanchez-Gonzalez, Alvaro; Willson, Matthew; Brenner, Michael P.; Hoyer, Stephan
  作者单位：Alphabet Inc.; Google Incorporated; Massachusetts Institute of Technology (MIT); European Centre for Medium-Range Weather Forecasts (ECMWF); Alphabet Inc.; DeepMind; Google Incorporated; Harvard University
  摘要：General circulation models (GCMs) are the foundation of weather and climate prediction1,2. GCMs are physics-based simulators that combine a numerical solver for large-scale dynamics with tuned representations for small-scale processes such as cloud formation. Recently, machine-learning models trained on reanalysis data have achieved comparable or better skill than GCMs for deterministic weather forecasting3,4. However, these models have not demonstrated improved ensemble forecasts, or shown su...
• Molecular and physiological changes in the SpaceX Inspiration4 civilian crew AI翻译
  作者：Jones, Christopher W.; Overbey, Eliah G.; Lacombe, Jerome; Ecker, Adrian J.; Meydan, Cem; Ryon, Krista; Tierney, Braden; Damle, Namita; Mackay, Matthew; Afshin, Evan E.; Foox, Jonathan; Park, Jiwoon; Nelson, Theodore M.; Mohamad, Mir Suhail; Byhaqui, Syed Gufran Ahmad; Aslam, Burhan; Tali, Ummer Akbar; Nisa, Liaqun; Menon, Priya V.; Patel, Chintan O.; Khan, Sharib A.; Ebert, Doug J.; Everson, Aaron; Schubert, Michael C.; Ali, Nabila N.; Sarma, Mallika S.; Kim, Jangkeun; Houerbi, Nadia; Grigorev, Kirill; Medina, J. Sebastian Garcia; Summers, Alexander J.; Gu, Jian; Altin, John A.; Fattahi, Ali; Hirzallah, Mohammad I.; Wu, Jimmy H.; Stahn, Alexander C.; Beheshti, Afshin; Klotz, Remi; Ortiz, Veronica; Yu, Min; Patras, Laura; Matei, Irina; Lyden, David; Melnick, Ari; Banerjee, Neil; Mullane, Sean; Kleinman, Ashley S.; Loesche, Michael; Menon, Anil S.; Donoviel, Dorit B.; Urquieta, Emmanuel; Mateus, Jaime; Sargsyan, Ashot E.; Shelhamer, Mark; Zenhausern, Frederic; Bershad, Eric M.; Basner, Mathias; Mason, Christopher E.
  作者单位：University of Pennsylvania; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Arizona; University of Arizona; NewYork-Presbyterian Hospital; Columbia University; Johns Hopkins University; Translational Genomics Research Institute; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; University of Southern California; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Babes Bolyai University from Cluj; Cornell University; Weill Cornell Medicine; SpaceX; University of Texas System; University of Texas Health Science Center Houston; University of Arizona
  摘要：Human spaceflight has historically been managed by government agencies, such as in the NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight to a broader population. In 2021, the SpaceX Inspiration4 mission launched the first all-civilian crew to low Earth orbit, which included the youngest American astronaut (aged 29), new in-flight experimental technologies (handheld ultrasound imaging, smartwatch wearables and immune profiling), ocular alignment measurement...
• De novo design of allosterically switchable protein assemblies AI翻译
  作者：Pillai, Arvind; Idris, Abbas; Philomin, Annika; Weidle, Connor; Skotheim, Rebecca; Leung, Philip J. Y.; Broerman, Adam; Demakis, Cullen; Borst, Andrew J.; Praetorius, Florian; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Institute of Science & Technology - Austria
  摘要：Allosteric modulation of protein function, wherein the binding of an effector to a protein triggers conformational changes at distant functional sites, plays a central part in the control of metabolism and cell signalling1-3. There has been considerable interest in designing allosteric systems, both to gain insight into the mechanisms underlying such 'action at a distance' modulation and to create synthetic proteins whose functions can be regulated by effectors4-7. However, emulating the subtl...
• Study the long-term human fallout of war AI翻译
  作者：Newcombe, Patrick B.
  作者单位：Princeton University
• Variants in a small RNA gene cause a rare disorder AI翻译
  作者：Heyne, Henrike O.
  作者单位：University of Potsdam
  摘要：Genetic variants in RNU4-2, a gene in a part of the genome not usually in the spotlight, have been identified as the cause of a developmental disorder in a large number of individuals who previously lacked a diagnosis.