作者：Hedley, Esme; Cech, Jakub
作者：Harnik, Yotam; Yakubovsky, Oran; Hoefflin, Rouven; Novoselsky, Roy; Halpern, Keren Bahar; Barkai, Tal; Kohanim, Yael Korem; Egozi, Adi; Golani, Ofra; Addadi, Yoseph; Kedmi, Merav; Haran, Tal Keidar; Levin, Yishai; Savidor, Alon; Keren-Shaul, Hadas; Mayer, Chen; Pencovich, Niv; Pery, Ron; Shouval, Dror S.; Tirosh, Itay; Nachmany, Ido; Itzkovitz, Shalev
作者单位：Weizmann Institute of Science; Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University; Yale University; Weizmann Institute of Science; Hebrew University of Jerusalem; Hadassah University Medical Center; Weizmann Institute of Science; Chaim Sheba Medical Center; Tel Aviv University; Tel Aviv University
摘要：The mouse small intestine shows profound variability in gene expression along the crypt-villus axis(1,2). Whether similar spatial heterogeneity exists in the adult human gut remains unclear. Here we use spatial transcriptomics, spatial proteomics and single-molecule fluorescence in situ hybridization to reconstruct a comprehensive spatial expression atlas of the adult human proximal small intestine. We describe zonated expression and cell type representation for epithelial, mesenchymal and imm...
作者：Chen, Shuli; Stark, Scott C.; Nobre, Antonio Donato; Cuartas, Luz Adriana; Amore, Diogo de Jesus; Restrepo-Coupe, Natalia; Smith, Marielle N.; Chitra-Tarak, Rutuja; Ko, Hongseok; Nelson, Bruce W.; Saleska, Scott R.
作者：Armitage, David W.
作者单位：Okinawa Institute of Science & Technology Graduate University
作者：Lovinger, Gabriel J.; Sak, Marcus H.; Jacobsen, Eric N.
作者单位：Harvard University
摘要：Bimolecular nucleophilic substitution (S(N)2) mechanisms occupy a central place in the historical development and teaching of the field of organic chemistry(1). Despite the importance of S(N)2 pathways in synthesis, catalytic control of ionic S(N)2 pathways is rare and notably uncommon even in biocatalysis(2,3), reflecting the fact that any electrostatic interaction between a catalyst and the reacting ion pair necessarily stabilizes its charge and, by extension, reduces polar reactivity. Nucle...
作者：Jain, Piyush
摘要：Bursts of light hint that a star in a nearby galaxy was partially shredded in 2022 and 2024 and might be in for another round.
作者：Mogil, Jeffrey S.
作者单位：McGill University; McGill University; McGill University; McGill University; McGill University; McGill University; McGill University
摘要：By tracing the neural circuits that are active when mice anticipate pain relief, neuroscientists find that the placebo effect involves the cerebellum and brain stem - areas that typically mediate 'lower' brain functions.
