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作者：Lyle, Clare; Pascanu, Razvan
作者单位：Alphabet Inc.; DeepMind; Alphabet Inc.; Google Incorporated; DeepMind
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作者：[Anonymous]
摘要：Degradation of the Amazon's tree canopy is the main culprit, although the complete clearance of portions of the forest contributes too.
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作者：Rashid, Raphael
摘要：Efforts to join the global ecosystem depend on greater diversity and a more open culture.
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作者：Luo, Na; Turberg, Mathias; Leutzsch, Markus; Mitschke, Benjamin; Brunen, Sebastian; Wakchaure, Vijay N.; Noethling, Nils; Schelwies, Mathias; Pelzer, Ralf; List, Benjamin
作者单位：Max Planck Society; BASF; BASF
摘要：Polyene cyclizations are among the most complex and challenging transformations in biology. In a single reaction step, multiple carbon-carbon bonds, ring systems and stereogenic centres are constituted from simple, acyclic precursors(1-3). Simultaneously achieving this kind of precise control over product distribution and stereochemistry poses a formidable task for chemists. In particular, the polyene cyclization of (3E,7E)-homofarnesol to the valuable naturally occurring ambergris odorant (-)...
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作者：Fu, Guangwei; Welbanks, Luis; Deming, Drake; Inglis, Julie; Zhang, Michael; Lothringer, Joshua; Ih, Jegug; Moses, Julianne I.; Schlawin, Everett; Knutson, Heather A.; Henry, Gregory; Greene, Thomas; Sing, David K.; Savel, Arjun B.; Kempton, Eliza M. -R.; Louie, Dana R.; Line, Michael; Nixon, Matt
作者单位：Johns Hopkins University; Arizona State University; Arizona State University-Tempe; University System of Maryland; University of Maryland College Park; California Institute of Technology; University of Chicago; Utah System of Higher Education; Utah Valley University; University of Arizona; Tennessee State University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
摘要：As the closest transiting hot Jupiter to Earth, HD 189733b has been the benchmark planet for atmospheric characterization(1-3). It has also been the anchor point for much of our theoretical understanding of exoplanet atmospheres from composition(4), chemistry(5,6), aerosols(7) to atmospheric dynamics(8), escape(9) and modelling techniques(10,11). Previous studies of HD 189733b have detected carbon and oxygen-bearing molecules H2O and CO (refs. 12,13) in the atmosphere. The presence of CO2 and ...
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作者：Deng, Hanbin; Qin, Hailang; Liu, Guowei; Yang, Tianyu; Fu, Ruiqing; Zhang, Zhongyi; Wu, Xianxin; Wang, Zhiwei; Shi, Youguo; Liu, Jinjin; Liu, Hongxiong; Yan, Xiao-Yu; Song, Wei; Xu, Xitong; Zhao, Yuanyuan; Yi, Mingsheng; Xu, Gang; Hohmann, Hendrik; Holbaek, Sofie Castro; Duerrnagel, Matteo; Zhou, Sen; Chang, Guoqing; Yao, Yugui; Wang, Qianghua; Guguchia, Zurab; Neupert, Titus; Thomale, Ronny; Fischer, Mark H.; Yin, Jia-Xin
作者单位：Southern University of Science & Technology; Chinese Academy of Sciences; Institute of Theoretical Physics, CAS; Hong Kong University of Science & Technology; Beijing Institute of Technology; Beijing Institute of Technology; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Songshan Lake Materials Laboratory; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Huazhong University of Science & Technology; Huazhong University of Science & Technology; University of Wurzburg; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Nanyang Technological University; Nanjing University; Nanjing University; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute
摘要：Superconductivity involving finite-momentum pairing(1) can lead to spatial-gap and pair-density modulations, as well as Bogoliubov Fermi states within the superconducting gap. However, the experimental realization of their intertwined relations has been challenging. Here we detect chiral kagome superconductivity modulations with residual Fermi arcs in KV3Sb5 and CsV3Sb5 using normal and Josephson scanning tunnelling microscopy down to 30 millikelvin with a resolved electronic energy difference...
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作者：Pan, Yude; Birdsey, Richard A.; Phillips, Oliver L.; Houghton, Richard A.; Fang, Jingyun; Kauppi, Pekka E.; Keith, Heather; Kurz, Werner A.; Ito, Akihiko; Lewis, Simon L.; Nabuurs, Gert-Jan; Shvidenko, Anatoly; Hashimoto, Shoji; Lerink, Bas; Schepaschenko, Dmitry; Castanho, Andrea; Murdiyarso, Daniel
作者单位：United States Department of Agriculture (USDA); United States Forest Service; University of Leeds; Peking University; University of Helsinki; Swedish University of Agricultural Sciences; Griffith University; Griffith University - Gold Coast Campus; Natural Resources Canada; Canadian Forest Service; University of Tokyo; University of London; University College London; Wageningen University & Research; Wageningen University & Research; International Institute for Applied Systems Analysis (IIASA); Forestry & Forest Products Research Institute - Japan; Bogor Agricultural University
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作者：Chen, Hsiao-Chi; He, Peihao; McDonald, Malcolm; Williamson, Michael R.; Varadharajan, Srinidhi; Lozzi, Brittney; Woo, Junsung; Choi, Dong-Joo; Sardar, Debosmita; Huang-Hobbs, Emmet; Sun, Hua; Ippagunta, Siri M.; Jain, Antrix; Rao, Ganesh; Merchant, Thomas E.; Ellison, David W.; Noebels, Jeffrey L.; Bertrand, Kelsey C.; Mack, Stephen C.; Deneen, Benjamin
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital
摘要：Bidirectional communication between tumours and neurons has emerged as a key facet of the tumour microenvironment that drives malignancy(1,2). Another hallmark feature of cancer is epigenomic dysregulation, in which alterations in gene expression influence cell states and interactions with the tumour microenvironment(3). Ependymoma (EPN) is a paediatric brain tumour that relies on epigenomic remodelling to engender malignancy(4,5); however, how these epigenetic mechanisms intersect with extrin...
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作者：Ma, Shoucai; An, Chunpeng; Lawson, Aaron W.; Cao, Yu; Sun, Yue; Tan, Eddie Yong Jun; Pan, Jinheng; Jirschitzka, Jan; Kuemmel, Florian; Mukhi, Nitika; Han, Zhifu; Feng, Shan; Wu, Bin; Schulze-Lefert, Paul; Chai, Jijie
作者单位：Westlake Laboratory; Westlake University; Xianghu Laboratory; Max Planck Society; Nanyang Technological University; University of Cologne; Max Planck Society
摘要：Nucleotide-binding leucine-rich repeat (NLR) proteins play a pivotal role in plant immunity by recognizing pathogen effectors1,2. Maintaining a balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity3,4. Unlike most NLRs, the plant NLR required for cell death 2 (NRC2) belongs to a small NLR group characterized by constitutively high expression without self-activation5. The mechanisms underlying NRC2 autoinhibition and activation are not yet understo...
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作者：Chen, Yuyang; Dawes, Ruebena; Kim, Hyung Chul; Ljungdahl, Alicia; Stenton, Sarah L.; Walker, Susan; Lord, Jenny; Lemire, Gabrielle; Martin-Geary, Alexandra C.; Ganesh, Vijay S.; Ma, Jialan; Ellingford, Jamie M.; Delage, Erwan; D'Souza, Elston N.; Dong, Shan; Adams, David R.; Allan, Kirsten; Bakshi, Madhura; Baldwin, Erin E.; Berger, Seth I.; Bernstein, Jonathan A.; Bhatnagar, Ishita; Blair, Ed; Brown, Natasha J.; Burrage, Lindsay C.; Chapman, Kimberly; Coman, David J.; Compton, Alison G.; Cunningham, Chloe A.; D'Souza, Precilla; Danecek, Petr; Delot, Emmanuele C.; Dias, Kerith-Rae; Elias, Ellen R.; Elmslie, Frances; Evans, Care-Anne; Ewans, Lisa; Ezell, Kimberly; Fraser, Jamie L.; Gallacher, Lyndon; Genetti, Casie A.; Goriely, Anne; Grant, Christina L.; Haack, Tobias; Higgs, Jenny E.; Hinch, Anjali G.; Hurles, Matthew E.; Kuechler, Alma; Lachlan, Katherine L.; Lalani, Seema R.; Lecoquierre, Francois; Leitao, Elsa; Le Fevre, Anna; Leventer, Richard J.; Liebelt, Jan E.; Lindsay, Sarah; Lockhart, Paul J.; Ma, Alan S.; Macnamara, Ellen F.; Mansour, Sahar; Maurer, Taylor M.; Mendez, Hector R.; Metcalfe, Kay; Montgomery, Stephen B.; Moosajee, Mariya; Nassogne, Marie-Cecile; Neumann, Serena; O'Donoghue, Michael; O'Leary, Melanie; Palmer, Elizabeth E.; Pattani, Nikhil; Phillips, John; Pitsava, Georgia; Pysar, Ryan; Rehm, Heidi L.; Reuter, Chloe M.; Revencu, Nicole; Riess, Angelika; Rius, Rocio; Rodan, Lance; Roscioli, Tony; Rosenfeld, Jill A.; Sachdev, Rani; Shaw-Smith, Charles J.; Simons, Cas; Sisodiya, Sanjay M.; Snell, Penny; St Clair, Laura; Stark, Zornitza; Stewart, Helen S.; Tan, Tiong Yang; Tan, Natalie B.; Temple, Suzanna E. L.; Thorburn, David R.; Tifft, Cynthia J.; Uebergang, Eloise; VanNoy, Grace E.; Vasudevan, Pradeep; Vilain, Eric; Viskochil, David H.; Wedd, Laura; Wheeler, Matthew T.; White, Susan M.; Wojcik, Monica; Wolfe, Lynne A.; Wolfenson, Zoe; Wright, Caroline F.; Xiao, Changrui; Zocche, David; Rubenstein, John L.; Markenscoff-Papadimitriou, Eirene; Fica, Sebastian M.; Baralle, Diana; Depienne, Christel; MacArthur, Daniel G.; Howson, Joanna M. M.; Sanders, Stephan J.; O'Donnell-Luria, Anne; Whiffin, Nicola
作者单位：University of Oxford; University of Oxford; Wellcome Centre for Human Genetics; University of Oxford; University of California System; University of California San Francisco; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Sheffield; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Manchester University NHS Foundation Trust; University of Manchester; Wellcome Trust Sanger Institute; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Murdoch Children's Research Institute; Victorian Clinical Genetics Services; Liverpool Hospital; Utah System of Higher Education; University of Utah; Children's National Health System; Children's National Health System; Stanford University; Stanford University; Stanford University; Oxford University Hospitals NHS Foundation Trust; University of Melbourne; Baylor College of Medicine; Childrens Health Queensland Hospital & Health Service; Queensland Childrens Hospital; University of Queensland; Griffith University; Griffith University - Gold Coast Campus; Murdoch Children's Research Institute; Neuroscience Research Australia; University of New South Wales Sydney; Children's Hospital Colorado; University of Colorado System; University of Colorado Anschutz Medical Campus; University of New South Wales Sydney; Prince of Wales Hospital (POWH); University of New South Wales Sydney; NSW Health; Sydney Childrens Hospitals Network; Garvan Institute of Medical Research; Vanderbilt University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Oxford; University of Oxford; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; University of Liverpool; University of Duisburg Essen; University of Southampton; Universite de Rouen Normandie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Rouen Normandie; CHU de Rouen; Royal Children's Hospital Melbourne; Murdoch Children's Research Institute; NSW Health; Sydney Childrens Hospitals Network; University of Sydney; Stanford University; Stanford University; University of Manchester; Manchester University NHS Foundation Trust; Stanford University; University of London; University College London; Francis Crick Institute; University of London; University College London; Moorfields Eye Hospital NHS Foundation Trust; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Nottingham University Hospital NHS Trust; University of California System; University of California Irvine; University of Sydney; NSW Health; Sydney Childrens Hospitals Network; The Children's Hospital at Westmead; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Garvan Institute of Medical Research; University of New South Wales Sydney; Murdoch Children's Research Institute; University of London; University College London; University of New South Wales Sydney; University of Leicester; University of California System; University of California Irvine; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Exeter; University of California System; University of California Irvine; Imperial College London; Imperial College London; University of California System; University of California San Francisco; University of Oxford; University of Southampton; University of Southampton; University Hospital Southampton NHS Foundation Trust
摘要：Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes1. Large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here we identify the non-coding RNA RNU4-2 as a syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical component of the U4/U6.U5 tri-snRNP complex of the major spliceosome2. We identify an 18 base ...
