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作者：Prashar, Akriti; Bussi, Claudio; Fearns, Antony; Capurro, Mariana I.; Gao, Xiaodong; Sesaki, Hiromi; Gutierrez, Maximiliano G.; Jones, Nicola L.
作者单位：University of Toronto; Hospital for Sick Children (SickKids); Francis Crick Institute; Johns Hopkins University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Nanyang Technological University
摘要：Mitochondrial membranes define distinct structural and functional compartments. Cristae of the inner mitochondrial membrane (IMM) function as independent bioenergetic units that undergo rapid and transient remodelling, but the significance of this compartmentalized organization is unknown(1). Using super-resolution microscopy, here we show that cytosolic IMM vesicles, devoid of outer mitochondrial membrane or mitochondrial matrix, are formed during resting state. These vesicles derived from th...
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作者：Espinoza, Nestor; Steinrueck, Maria E.; Kirk, James; MacDonald, Ryan J.; Savel, Arjun B.; Arnold, Kenneth; Kempton, Eliza M. -R.; Murphy, Matthew M.; Carone, Ludmila; Zamyatina, Maria; Lewis, David A.; Samra, Dominic; Kiefer, Sven; Rauscher, Emily; Christie, Duncan; Mayne, Nathan; Helling, Christiane; Rustamkulov, Zafar; Parmentier, Vivien; May, Erin M.; Carter, Aarynn L.; Zhang, Xi; Lopez-Morales, Mercedes; Allen, Natalie; Blecic, Jasmina; Decin, Leen; Mancini, Luigi; Molaverdikhani, Karan; Rackham, Benjamin V.; Palle, Enric; Tsai, Shang-Min; Ahrer, Eva-Maria; Bean, Jacob L.; Crossfield, Ian J. M.; Haegele, David; Hebrard, Eric; Kreidberg, Laura; Powell, Diana; Schneider, Aaron D.; Welbanks, Luis; Wheatley, Peter; Brahm, Rafael; Crouzet, Nicolas
作者单位：Space Telescope Science Institute; Johns Hopkins University; Max Planck Society; University of Chicago; Imperial College London; University of Michigan System; University of Michigan; University System of Maryland; University of Maryland College Park; University of Arizona; University of Arizona; Austrian Academy of Sciences; University of Exeter; Graz University of Technology; KU Leuven; University of St Andrews; Graz University of Technology; Universite Cote d'Azur; Observatoire de la Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz; Smithsonian Institution; New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi; University of Rome Tor Vergata; Istituto Nazionale Astrofisica (INAF); University of Munich; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Instituto de Astrofisica de Canarias; University of California System; University of California Riverside; University of Warwick; University of Kansas; University of Copenhagen; Niels Bohr Institute; Arizona State University; Arizona State University-Tempe; Universidad Adolfo Ibanez; Leiden University; Leiden University - Excl LUMC
摘要：Transmission spectroscopy has been a workhorse technique used over the past two decades to constrain the physical and chemical properties of exoplanet atmospheres1-5. One of its classical key assumptions is that the portion of the atmosphere it probes-the terminator region-is homogeneous. Several works from the past decade, however, have put this into question for highly irradiated, hot (Teq greater than or similar to 1,000 K) gas giant exoplanets, both empirically6-10 and through three-dimens...
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作者：Booth, Michael J.; Sella, Andrea
作者单位：University of London; University College London
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作者：Tang, Haoning; Wang, Yiting; Ni, Xueqi; Watanabe, Kenji; Taniguchi, Takashi; Jarillo-Herrero, Pablo; Fan, Shanhui; Mazur, Eric; Yacoby, Amir; Cao, Yuan
作者单位：Harvard University; National Institute for Materials Science; Massachusetts Institute of Technology (MIT); Stanford University; Stanford University; Harvard University; Harvard University; University of California System; University of California Berkeley
摘要：Two-dimensional materials (2DM) and their heterostructures offer tunable electrical and optical properties, primarily modifiable through electrostatic gating and twisting. Although electrostatic gating is a well-established method for manipulating 2DM, achieving real-time control over interfacial properties remains challenging in exploring 2DM physics and advanced quantum device technology(1-6). Current methods, often reliant on scanning microscopes, are limited in their scope of application, ...
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作者：Roje, Blanka; Zhang, Boyao; Mastrorilli, Eleonora; Kovacic, Ana; Susak, Lana; Ljubenkov, Ivica; Cosic, Elena; Vilovic, Katarina; Mestrovic, Antonio; Vukovac, Emilija Lozo; Bucevic-Popovic, Viljemka; Puljiz, Zeljko; Karaman, Ivana; Terzic, Janos; Zimmermann, Michael
作者单位：University of Split; European Molecular Biology Laboratory (EMBL); University of Split; University of Split; University of Split; University of Split; Ruprecht Karls University Heidelberg; European Molecular Biology Laboratory (EMBL)
摘要：Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development(1,2). Similar to drug molecules, pollutants are typically metabolized in the body, which can change their carcinogenic potential and affect tissue distribution through altered toxicokinetics(3). Although recent studies demonstrated that human-associated microorganisms can chemically convert a wide range of xenobiotics and influence the profile and tissue exposure of...
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作者：Krukenberg, Viola; Kohtz, Anthony J.; Jay, Zackary J.; Hatzenpichler, Roland
作者单位：Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman
摘要：Methanogenesis mediated by archaea is the main source of methane, a strong greenhouse gas, and thus is critical for understanding Earth's climate dynamics. Recently, genes encoding diverse methanogenesis pathways have been discovered in metagenome-assembled genomes affiliated with several archaeal phyla1-7. However, all experimental studies on methanogens are at present restricted to cultured representatives of the Euryarchaeota. Here we show methanogenic growth by a member of the lineage Kora...
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作者：Adarsh, S.; Shamla, D. S.; Nair, G. R. Arathy; Mohan, Meera G.
作者单位：Thangal Kunju Musaliar College of Engineering
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作者：Sala, Enric
作者单位：National Geographic Society
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作者：Chen, Wei; Choi, Junhong; Li, Xiaoyi; Nathans, Jenny F.; Martin, Beth; Yang, Wei; Hamazaki, Nobuhiko; Qiu, Chengxiang; Lalanne, Jean-Benoit; Regalado, Samuel; Kim, Haedong; Agarwal, Vikram; Nichols, Eva; Leith, Anh; Lee, Choli; Shendure, Jay
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Measurements of gene expression or signal transduction activity are conventionally performed using methods that require either the destruction or live imaging of a biological sample within the timeframe of interest. Here we demonstrate an alternative paradigm in which such biological activities are stably recorded to the genome. Enhancer-driven genomic recording of transcriptional activity in multiplex (ENGRAM) is based on the signal-dependent production of prime editing guide RNAs that mediat...
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作者：Lenharo, Mariana
摘要：Early results from clinical trial show that the antiviral drug tecovirimat is no better than placebo against the clade I virus type.
