8067期

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• PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease AI翻译
  作者：Nyame, Kwamina; Xiong, Jian; Alsohybe, Hisham N.; de Jong, Arthur P. H.; Pena, Isabelle V.; de Miguel, Ricardo; Brummelkamp, Thijn R.; Hartmann, Guido; Nijman, Sebastian M. B.; Raaben, Matthijs; Simcox, Judith A.; Blomen, Vincent A.; Abu-Remaileh, Monther
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Netherlands Cancer Institute; Howard Hughes Medical Institute; University of Wisconsin System; University of Wisconsin Madison; Stanford University
  摘要：Lysosomes catabolize lipids and other biological molecules, maintaining cellular and organismal homeostasis. Bis(monoacylglycero)phosphate (BMP), a major lipid constituent of intralysosomal vesicles, stimulates lipid-degrading enzymes and is altered in various human conditions, including neurodegenerative diseases1,2. Although lysosomal BMP synthase was recently discovered3, the enzymes mediating BMP turnover remain elusive. Here we show that lysosomal phospholipase PLA2G15 is a physiological ...
• Towards accurate differential diagnosis with large language models AI翻译
  作者：McDuff, Daniel; Schaekermann, Mike; Tu, Tao; Palepu, Anil; Wang, Amy; Garrison, Jake; Singhal, Karan; Sharma, Yash; Azizi, Shekoofeh; Kulkarni, Kavita; Hou, Le; Cheng, Yong; Liu, Yun; Mahdavi, S. Sara; Prakash, Sushant; Pathak, Anupam; Semturs, Christopher; Patel, Shwetak; Webster, Dale R.; Dominowska, Ewa; Gottweis, Juraj; Barral, Joelle; Chou, Katherine; Corrado, Greg S.; Matias, Yossi; Sunshine, Jake; Karthikesalingam, Alan; Natarajan, Vivek
  作者单位：Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind; Alphabet Inc.; DeepMind; Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind; Alphabet Inc.; Google Incorporated
  摘要：A comprehensive differential diagnosis is a cornerstone of medical care that is often reached through an iterative process of interpretation that combines clinical history, physical examination, investigations and procedures. Interactive interfaces powered by large language models present new opportunities to assist and automate aspects of this process1. Here we introduce the Articulate Medical Intelligence Explorer (AMIE), a large language model that is optimized for diagnostic reasoning, and...
• Making slabs and sleepers from old appliances AI翻译
  作者：Noronha, Patricia Maia
• Activation of lysosomal iron triggers ferroptosis in cancer AI翻译
  作者：Caneque, Tatiana; Baron, Leeroy; Mueller, Sebastian; Carmona, Alanis; Colombeau, Ludovic; Versini, Antoine; Solier, Stephanie; Gaillet, Christine; Sindikubwabo, Fabien; Sampaio, Julio L.; Sabatier, Marie; Mishima, Eikan; Picard-Bernes, Armel; Syx, Laurene; Servant, Nicolas; Lombard, Berangere; Loew, Damarys; Zheng, Jiashuo; Proneth, Bettina; Thoidingjam, Leishemba K.; Grimaud, Laurence; Fraser, Cameron S.; Szylo, Krystina J.; Kazarian, Emma Der; Bonnet, Caroline; Charafe-Jauffret, Emmanuelle; Ginestier, Christophe; Santofimia-Castano, Patricia; Estaras, Matias; Dusetti, Nelson; Iovanna, Juan Lucio; Cunha, Antonio Sa; Pittau, Gabriella; Hammel, Pascal; Tzanis, Dimitri; Bonvalot, Sylvie; Watson, Sarah; Gandon, Vincent; Upadhyay, Aditya; Pratt, Derek A.; Freitas, Florencio Porto; Angeli, Jose Pedro Friedmann; Stockwell, Brent R.; Conrad, Marcus; Ubellacker, Jessalyn M.; Rodriguez, Raphael
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Harvard University; Harvard T.H. Chan School of Public Health; UNICANCER; Universite PSL; Institut Curie; Universite Paris Saclay; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; UNICANCER; Universite PSL; Institut Curie; MINES ParisTech; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Institut Paoli-Calmette (IPC); Centre National de la Recherche Scientifique (CNRS); UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite; Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP; UNICANCER; Universite PSL; Institut Curie; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); University of Ottawa; University of Wurzburg; Columbia University; Columbia University; Columbia University; Technical University of Munich
  摘要：Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic approaches have revealed suppressors of ferroptosis2, 3-4; by contrast, small molecules can provide spatiotemporal control of the chemistry at work5. Here we show that the ferroptosis inhibitor liproxstatin-1...
• Solved: the mystery of the evaporating planet AI翻译
  作者：[Anonymous]
• Global evolution of inflammatory bowel disease across epidemiologic stages AI翻译
  作者：Hracs, Lindsay; Windsor, Joseph W.; Gorospe, Julia; Cummings, Michael; Coward, Stephanie; Buie, Michael J.; Quan, Joshua; Goddard, Quinn; Caplan, Lea; Markovinovic, Ante; Williamson, Tyler; Abbey, Yvonne; Abdullah, Murdani; Abreu, Maria T.; Ahuja, Vineet; Raja Ali, Raja Affendi; Altuwaijri, Mansour; Balderramo, Domingo; Banerjee, Rupa; Benchimol, Eric I.; Bernstein, Charles N.; Brunet-Mas, Eduard; Burisch, Johan; Chong, Vui Heng; Dotan, Iris; Dutta, Usha; El Ouali, Sara; Forbes, Angela; Forss, Anders; Gearry, Richard; Dao, Viet Hang; Hartono, Juanda Leo; Hilmi, Ida; Hodges, Phoebe; Jones, Gareth-Rhys; Juliao-Banos, Fabian; Kaibullayeva, Jamilya; Kelly, Paul; Kobayashi, Taku; Kotze, Paulo Gustavo; Lakatos, Peter L.; Lees, Charlie W.; Limsrivilai, Julajak; Lo, Bobby; Loftus, Edward V.; Ludvigsson, Jonas F.; Mak, Joyce W. Y.; Miao, Yinglei; Ng, Ka Kei; Okabayashi, Shinji; Olen, Ola; Panaccione, Remo; Paudel, Mukesh Sharma; Quaresma, Abel Botelho; Rubin, David T.; Simadibrata, Marcellus; Sun, Yang; Suzuki, Hidekazu; Toro, Martin; Turner, Dan; Iade, Beatriz; Wei, Shu Chen; Yamamoto-Furusho, Jesus K.; Yang, Suk-Kyun; Ng, Siew C.; Kaplan, Gilaad G.
  作者单位：University of Calgary; University of Calgary; University of Indonesia; Dr. Cipto Mangunkusumo National Public Hospital; Cedars Sinai Medical Center; Stockholm School of Economics; All India Institute of Medical Sciences (AIIMS) New Delhi; Sunway University; King Saud University; Hospital Privado - Universitario de Cordoba; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Manitoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Instituto de Salud Carlos III; Autonomous University of Barcelona; University of Copenhagen; Tel Aviv University; Sackler Faculty of Medicine; Rabin Medical Center; Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh; Cleveland Clinic Foundation; Cleveland Clinic Foundation; University of Otago; Karolinska Institutet; Hanoi Medical University; National University of Singapore; National University of Singapore; Universiti Malaya; University of London; Queen Mary University London; University of Zambia; University of Edinburgh; Asfendiyarov Kazakh National Medical University; Kitasato University; Kitasato University; McGill University; Semmelweis University; University of Edinburgh; Mahidol University; Mayo Clinic; Orebro University; Chinese University of Hong Kong; Kyoto University; Karolinska Institutet; Universidade do Oeste de Santa Catarina; University of Chicago; Tokai University; Hebrew University of Jerusalem; Shaare Zedek Medical Center; National Taiwan University; National Taiwan University Hospital; University of Ulsan; Asan Medical Center; Chinese University of Hong Kong; Chinese University of Hong Kong
  摘要：During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily2, 3-4. Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage...
• Genomics pioneer fired from firm he founded: 'It was not easy to domesticate me' AI翻译
  作者：Callaway, Ewen
• Do our observations make reality happen? AI翻译
  作者：Ney, Alyssa
  作者单位：University of Munich; University of Munich
• Imaging surface structure and premelting of ice Ih with atomic resolution (vol 630, pg 375, 2024) AI翻译
  作者：Hong, Jiani; Tian, Ye; Liang, Tiancheng; Liu, Xinmeng; Song, Yizhi; Guan, Dong; Yan, Zixiang; Guo, Jiadong; Tang, Binze; Cao, Duanyun; Guo, Jing; Chen, Ji; Pan, Ding; Xu, Li-Mei; Wang, En-Ge; Jiang, Ying
• Reduced investment in universities has multifaceted effects AI翻译
  作者：Hashiguchi, Akiko
  作者单位：University of Tsukuba