作者：Kraus, D.; Rips, J.; Schoerner, M.; Stevenson, M. G.; Vorberger, J.; Ranjan, D.; Luetgert, J.; Heuser, B.; Eggert, J. H.; Liermann, H. -p.; Oleynik, I. I.; Pandolfi, S.; Redmer, R.; Sollier, A.; Strohm, C.; Volz, T. J.; Albertazzi, B.; Ali, S. J.; Antonelli, L.; Baehtz, C.; Ball, O. B.; Banerjee, S.; Belonoshko, A. B.; Bolme, C. A.; Bouffetier, V.; Briggs, R.; Buakor, K.; Butcher, T.; Cerantola, V.; Chantel, J.; Coleman, A. L.; Collier, J.; Collins, G. W.; Comley, A. J.; Cowan, T. E.; Cristoforetti, G.; Cynn, H.; Descamps, A.; Di Cicco, A.; Di Dio Cafiso, S.; Dorchies, F.; Duff, M. J.; Dwivedi, A.; Edwards, C.; Errandonea, D.; Galitskiy, S.; Galtier, E.; Ginestet, H.; Gizzi, L.; Gleason, A.; Goede, S.; Gonzalez, J. M.; Gorman, M. G.; Harmand, M.; Hartley, N. J.; Heighway, P. G.; Hernandez-Gomez, C.; Higginbotham, A.; Hoeppner, H.; Husband, R. J.; Hutchinson, T. M.; Hwang, H.; Keen, D. A.; Kim, J.; Koester, P.; Konopkova, Z.; Krygier, A.; Labate, L.; Laso Garcia, A.; Lazicki, A. E.; Lee, Y.; Mason, P.; Masruri, M.; Massani, B.; McBride, E. E.; McHardy, J. D.; McGonegle, D.; McGuire, C.; Mcwilliams, R. S.; Merkel, S.; Morard, G.; Nagler, B.; Nakatsutsumi, M.; Nguyen-Cong, K.; Norton, A. -m.; Ozaki, N.; Otzen, C.; Peake, D. J.; Pelka, A.; Pereira, K. A.; Phillips, J. P.; Prescher, C.; Preston, T. R.; Randolph, L.; Ravasio, A.; Santamaria-Perez, D.; Savage, D. J.; Schoelmerich, M.; Schwinkendorf, J. -p.; Singh, S.; Smith, J.; Smith, R. F.; Spear, J.; Spindloe, C.; Suer, T. -a.; Tang, M.; Toncian, M.; Toncian, T.; Tracy, S. J.; Trapananti, A.; Vennari, C. E.; Vinci, T.; Tyldesley, M.; Vogel, S. C.; Walsh, J. P. S.; Wark, J. S.; Willman, J. T.; Wollenweber, L.; Zastrau, U.; Brambrink, E.; Appel, K.; McMahon, M. I.
作者单位：University of Rostock; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); State University System of Florida; University of South Florida; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; Museum National d'Histoire Naturelle (MNHN); Universite Paris Saclay; CEA; Institut Polytechnique de Paris; Ecole Polytechnique; CEA; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of York - UK; University of Edinburgh; University of Edinburgh; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Nanjing University; United States Department of Energy (DOE); Los Alamos National Laboratory; European XFEL; University of Milano-Bicocca; Universite de Lille; Centrale Lille; INRAE; Centre National de la Recherche Scientifique (CNRS); University of Rochester; University of Rochester; University of Rochester; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); Queens University Belfast; University of Camerino; Universite de Bordeaux; CEA; Centre National de la Recherche Scientifique (CNRS); University of Valencia; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); heSam Universite; Conservatoire National Arts & Metiers (CNAM); University of Oxford; Gwangju Institute of Science & Technology (GIST); UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Hanyang University; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); Yonsei University; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Universite Savoie Mont Blanc; University of Osaka; University of Freiburg; University of Massachusetts System; University of Massachusetts Amherst; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Carnegie Institution for Science
摘要：Carbon has a central role in biology and organic chemistry, and its solid allotropes provide the basis of much of our modern technology1. However, the liquid form of carbon remains nearly uncharted2, and the structure of liquid carbon and most of its physical properties are essentially unknown3. But liquid carbon is relevant for modelling planetary interiors4,5 and the atmospheres of white dwarfs6, as an intermediate state for the synthesis of advanced carbon materials7,8, inertial confinement...
作者：Tavakoli, Mojtaba R.; Lyudchik, Julia; Januszewski, Michal; Vistunou, Vitali; Duenas, Nathalie Agudelo; Vorlaufer, Jakob; Sommer, Christoph; Kreuzinger, Caroline; Oliveira, Barbara; Cenameri, Alban; Novarino, Gaia; Jain, Viren; Danzl, Johann G.
作者单位：Institute of Science & Technology - Austria; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated
摘要：The information-processing capability of the brain's cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and resolving their individual synaptic connections can be achieved by volumetric imaging at nanoscale resolution1,2 with dense cellular labelling. Light microscopy is uniquely positioned to visualize specific molecules, but dense, synapse-level circuit reconstruction by light microscopy has been out of ...
作者：Gozdecka, Malgorzata; Dudek, Monika; Wen, Sean; Gu, Muxin; Stopforth, Richard J.; Rak, Justyna; Damaskou, Aristi; Grice, Guinevere L.; McLoughlin, Matthew A.; Bond, Laura; Wilson, Rachael; Giotopoulos, George; Shanmugiah, Vijaya Mahalingam; Bakar, Rula Bany; Yankova, Eliza; Cooper, Jonathan L.; Narayan, Nisha; Horton, Sarah J.; Asby, Ryan; Pask, Dean C.; Mupo, Annalisa; Duddy, Graham; Marando, Ludovica; Georgomanolis, Theodoros; Carter, Paul; Ramesh, Amirtha Priya; Dunn, William G.; Barcena, Clea; Gallipoli, Paolo; Yusa, Kosuke; Petrovski, Slave; Wright, Penny; Quiros, Pedro M.; Frezza, Christian; Nathan, James A.; Kaser, Arthur; Kar, Siddhartha; Tzelepis, Konstantinos; Mitchell, Jonathan; Fabre, Margarete A.; Huntly, Brian J. P.; Vassiliou, George S.
作者单位：University of Cambridge; University of Cambridge; AstraZeneca; University of Cambridge; University of Cambridge; Francis Crick Institute; University of Cologne; University of Cambridge; University of Oviedo; Instituto Universitario de Oncologia de Asturias; University of London; Queen Mary University London; Kyoto University; Canterbury Health Laboratories; University of Cologne; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; Wellcome Trust Sanger Institute
摘要：Somatic DNMT3A-R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To identify DNMT3A-R882-mutant-specific vulnerabilities, we conducted a genome-wide CRISPR screen on primary mouse Dnmt3aR882H/+ HSPCs. Among the 640 vulnerability genes identified, many were involved in ...
作者：Qian, Weiyu; Mardyukov, Artur; Schreiner, Peter R.
作者单位：Justus Liebig University Giessen
摘要：Compounds consisting only of the element nitrogen (polynitrogens or nitrogen allotropes) are considered promising clean energy-storage materials owing to their immense energy content that is much higher than hydrogen, ammonia or hydrazine, which are in common use, and because they release only harmless nitrogen on decomposition1. However, their extreme instability poses a substantial synthetic challenge and no neutral molecular nitrogen allotrope beyond N2 has been isolated2,3. Here we present...
作者：Zhao, Yuanhong; Zheng, Bo; Saunois, Marielle; Ciais, Philippe; Hegglin, Michaela I.; Lu, Shengmin; Li, Yifan; Bousquet, Philippe
作者单位：Ocean University of China; Tsinghua Shenzhen International Graduate School; Tsinghua University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Cite; Helmholtz Association; Research Center Julich; University of Reading; University of Wuppertal
摘要：Air pollution affects climate through various complex interactions1. It perturbs the Earth's radiative energy balance and alters the atmospheric oxidation capacity, which determines the lifetimes of short-lived climate forcers, such as methane1. A key mechanism in this dynamic is the impact of air pollutants on the hydroxyl radical (OH), the most important oxidant in the troposphere, which accounts for approximately 90% of the methane chemical sink2. However, a comprehensive quantification of ...
