8067期

最新文章

• Milli-spinner thrombectomy AI翻译
  作者：Chang, Yilong; Wu, Shuai; Li, Qi; Pulli, Benjamin; Salmi, Darren; Yock, Paul; Heit, Jeremy J.; Zhao, Ruike Renee
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Clot-induced blockage in arteries or veins can cause severe medical conditions1. Mechanical thrombectomy is a minimally invasive technique used to treat ischaemic stroke, myocardial infarction, pulmonary embolism and peripheral vascular disease2, 3-4 by removing clots through aspiration5, stent retriever6 or cutting mechanisms7. However, current mechanical thrombectomy methods fail to remove clots in 10-30% of patients8, 9-10, especially in the case of large, fibrin-rich clots11. These methods...
• Small molecules restore mutant mitochondrial DNA polymerase activity AI翻译
  作者：Valenzuela, Sebastian; Zhu, Xuefeng; Macao, Bertil; Stamgren, Mattias; Geukens, Carol; Charifson, Paul S.; Kern, Gunther; Hoberg, Emily; Jenninger, Louise; Gruszczyk, Anja V.; Lee, Seoeun; Johansson, Katarina A. S.; Fuste, Javier Miralles; Shi, Yonghong; Kerns, S. Jordan; Arabanian, Laleh; Botella, Gabriel Martinez; Ekstroem, Sofie; Green, Jeremy; Griffin, Andrew M.; Pardo-Hernandez, Carlos; Keating, Thomas A.; Kuppers-Munther, Barbara; Larsson, Nils-Goran; Phan, Cindy; Posse, Viktor; Jones, Juli E.; Xie, Xie; Giroux, Simon; Gustafsson, Claes M.; Falkenberg, Maria
  作者单位：University of Gothenburg; Karolinska Institutet
  摘要：Mammalian mitochondrial DNA (mtDNA) is replicated by DNA polymerase gamma (POL gamma), a heterotrimeric complex consisting of a catalytic POL gamma A subunit and two accessory POL gamma B subunits1. More than 300 mutations in POLG, the gene encoding the catalytic subunit, have been linked to severe, progressive conditions with high rates of morbidity and mortality, for which no treatment exists2. Here we report on the discovery and characterization of PZL-A, a first-in-class small-molecule act...
• Mathematics in ancient Egypt AI翻译
  作者：[Anonymous]
• Painting restored with a digitally constructed mask AI翻译
  作者：Kutzke, Hartmut
  作者单位：University of Oslo
• Not all clinical data in the United States are fragmented AI翻译
  作者：Lewis, Enlli
• Greening nickel extraction requires institutional and financial support AI翻译
  作者：Liu, Zhangxin (Frank)
  作者单位：University of Western Australia
• Patriarchy Inc.: What We Get Wrong About Gender Equality and Why Men Still Win at Work AI翻译
  作者：Agarwal, Pragya
  作者单位：Loughborough University
• Rare 'ambidextrous' protein breaks rules of handedness AI翻译
  作者：Callaway, Ewen
• A complementary two-dimensional material-based one instruction set computer AI翻译
  作者：Ghosh, Subir; Zheng, Yikai; Rafiq, Musaib; Ravichandran, Harikrishnan; Sun, Yongwen; Chen, Chen; Goswami, Mrinmoy; Sakib, Najam U.; Sadaf, Muhtasim Ul Karim; Pannone, Andrew; Ray, Samriddha; Redwing, Joan M.; Yang, Yang; Sahay, Shubham; Das, Saptarshi
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Jadavpur University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Silicon has enabled advancements in semiconductor technology through miniaturization, but scaling challenges necessitate the exploration of new materials1. Two-dimensional (2D) materials, with their atomic thickness and high carrier mobility, offer a promising alternative2, 3, 4-5. Although significant progress has been made in wafer-scale growth6, 7-8, high-performance field-effect transistors9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19-20 and circuits based on 2D materials21, 22-23, achieving c...
• Brain tissue artificially expanded to show how neurons wire together AI翻译
  作者：Kornfeld, Joergen M. R.
  作者单位：MRC Laboratory Molecular Biology