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作者：Earl, Alexis D.; Carter, Gerald G.; Berlinger, Arden G.; Korir, Elkana; Shah, Shailee S.; Watetu, Wilson N.; Rubenstein, Dustin R.
作者单位：Columbia University; Princeton University; Smithsonian Institution; Smithsonian Tropical Research Institute; Howard Hughes Medical Institute; Cornell University; University of Cambridge; Cornell University
摘要：Identifying the mechanisms that underlie cooperation is fundamental to biology1. The most complex form of cooperation in vertebrates occurs in cooperative breeders, in which helpers forego reproduction and assist in raising the young of others, typically relatives2. Not all cooperative societies, however, are kin-based-nearly half of all avian3 and mammalian4 cooperative breeders form mixed-kin societies, much like those of humans5. Kin selection in mixed-kin societies occurs when individuals ...
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作者：Hosseini, Amir; Dhall, Abhinav; Ikonen, Nemo; Sikora, Natalia; Nguyen, Sylvain; Shen, Yuqi; Amaral, Maria Luisa Jurgensen; Jiao, Alan; Wallner, Felice; Sergeev, Philipp; Lim, Yuhua; Yang, Yuanqin; Vick, Binje; Kawabata, Kimihito Cojin; Melnick, Ari; Vyas, Paresh; Ren, Bing; Jeremias, Irmela; Psaila, Bethan; Heckman, Caroline A.; Blanco, M. Andres; Shi, Yang
作者单位：Ludwig Institute for Cancer Research; University of Oxford; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Helsinki; University of Oxford; University of California System; University of California San Diego; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Helmholtz Association; German Cancer Research Center (DKFZ); Cornell University; Weill Cornell Medicine; Oxford University Hospitals NHS Foundation Trust; University of Munich; University of Pennsylvania
摘要：Impaired differentiation is a hallmark of myeloid malignancies1,2. Therapies that enable cells to circumvent the differentiation block, such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), are by and large curative in acute promyelocytic leukaemia3, but whether 'differentiation therapy' is a generalizable therapeutic approach for acute myeloid leukaemia (AML) and beyond remains incompletely understood. Here we demonstrate that simultaneous inhibition of the histone demethylase LS...
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作者：Kwon, Diana
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作者：Lange, Mike; Olzmann, James A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
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作者：Sun, Hequan; Tusso, Sergio; Dent, Craig I.; Goel, Manish; Wijfjes, Raul Y.; Baus, Lisa C.; Dong, Xiao; Campoy, Jose A.; Kurdadze, Ana; Walkemeier, Birgit; Saenger, Christine; Huettel, Bruno; Hutten, Ronald C. B.; van Eck, Herman J.; Dehmer, Klaus J.; Schneeberger, Korbinian
作者单位：Xi'an Jiaotong University; Xi'an Jiaotong University; University of Munich; Max Planck Society; Heinrich Heine University Dusseldorf; Max Planck Society; Wageningen University & Research; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Universidad Politecnica de Cartagena
摘要：Potatoes were first brought to Europe in the sixteenth century1,2. Two hundred years later, one of the species had become one of the most important food sources across the entire continent and, later, even the entire world3. However, its highly heterozygous, autotetraploid genome has complicated its improvement since then4, 5, 6-7. Here we present the pan-genome of European potatoes generated from phased genome assemblies of ten historical potato cultivars, which includes approximately 85% of ...
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作者：Li, Luoqi; Long, Di; Wang, Yiming; Woolway, R. Iestyn
作者单位：Tsinghua University; Tsinghua University; Bangor University
摘要：Lakes are crucial for ecosystems1, greenhouse gas emissions2 and water resources3, yet their surface-extent dynamics, particularly seasonality, remain poorly understood at continental to global scales owing to limitations in satellite observations4,5. Although previous studies have focused on long-term changes6, 7-8, comprehensive assessments of seasonality have been constrained by trade-offs between spatial resolution and temporal resolution in single-source satellite data. Here we show that ...
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作者：Klebl, David P.; McMillan, Sean N.; Risi, Cristina; Forgacs, Eva; Virok, Betty; Atherton, Jennifer L.; Harris, Sarah A.; Stofella, Michele; Winkelmann, Donald A.; Sobott, Frank; Galkin, Vitold E.; Knight, Peter J.; Muench, Stephen P.; Scarff, Charlotte A.; White, Howard D.
作者单位：University of Leeds; University of Leeds; University of Leeds; University of Leeds; Old Dominion University; University of Sheffield; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Max Planck Society
摘要：Myosins produce force and movement in cells through interactions with F-actin1. Generation of movement is thought to arise through actin-catalysed conversion of myosin from an ATP-generated primed (pre-powerstroke) state to a post-powerstroke state, accompanied by myosin lever swing2,3. However, the initial, primed actomyosin state has never been observed, and the mechanism by which actin catalyses myosin ATPase activity is unclear. Here, to address these issues, we performed time-resolved cry...
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作者：Tu, Tao; Schaekermann, Mike; Palepu, Anil; Saab, Khaled; Freyberg, Jan; Tanno, Ryutaro; Wang, Amy; Li, Brenna; Amin, Mohamed; Cheng, Yong; Vedadi, Elahe; Tomasev, Nenad; Azizi, Shekoofeh; Singhal, Karan; Hou, Le; Webson, Albert; Kulkarni, Kavita; Mahdavi, S. Sara; Semturs, Christopher; Gottweis, Juraj; Barral, Joelle; Chou, Katherine; Corrado, Greg S.; Matias, Yossi; Karthikesalingam, Alan; Natarajan, Vivek
作者单位：Alphabet Inc.; Google Incorporated; Alphabet Inc.; DeepMind
摘要：At the heart of medicine lies physician-patient dialogue, where skillful history-taking enables effective diagnosis, management and enduring trust1,2. Artificial intelligence (AI) systems capable of diagnostic dialogue could increase accessibility and quality of care. However, approximating clinicians' expertise is an outstanding challenge. Here we introduce AMIE (Articulate Medical Intelligence Explorer), a large language model (LLM)-based AI system optimized for diagnostic dialogue. AMIE use...
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作者：[Anonymous]
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作者：Hosseini, Mohsen; Voisin, Veronique; Chegini, Ali; Varesi, Angelica; Cathelin, Severine; Ayyathan, Dhanoop Manikoth; Liu, Alex C. H.; Yang, Yitong; Wang, Vivian; Maher, Abdula; Grignano, Eric; Reisz, Julie A.; D'Alessandro, Angelo; Young, Kira; Wu, Yiyan; Fiumara, Martina; Ferrari, Samuele; Naldini, Luigi; Gaiti, Federico; Pai, Shraddha; Egan, Grace; Schimmer, Aaron D.; Bader, Gary D.; Dick, John E.; Xie, Stephanie Z.; Trowbridge, Jennifer J.; Chan, Steven M.
作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University of Toronto; University of Toronto; University of Colorado System; University of Colorado Anschutz Medical Campus; Jackson Laboratory; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); Vita-Salute San Raffaele University; University of Toronto; Ontario Institute for Cancer Research; University of Toronto; Hospital for Sick Children (SickKids)
摘要：Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1, 2, 3-4. Suppressing the expansion of mutant HSCs may prevent these outcomes; however, such interventions have not yet been identified. The most common clonal haematopoiesis ...
