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作者：Chen, Amanda X. Y.; Yap, Kah Min; Kim, Joelle S.; Sek, Kevin; Huang, Yu-Kuan; Dunbar, Phoebe A.; Wiebking, Volker; Armitage, Jesse D.; Munoz, Isabelle; Todd, Kirsten L.; Derrick, Emily B.; Nguyen, Dat; Tong, Junming; Chan, Cheok Weng; Hoang, Thang X.; Audsley, Katherine M.; van Elsas, Marit J.; Middelburg, Jim; Lee, Joel N.; de Menezes, Maria N.; Cole, Thomas J.; Li, Jasmine; Scheffler, Christina; Scott, Andrew M.; Mackay, Laura K.; Waithman, Jason; Oliaro, Jane; Harrison, Simon J.; Parish, Ian A.; Lai, Junyun; Porteus, Matthew H.; House, Imran G.; Darcy, Phillip K.; Beavis, Paul A.
作者单位：Peter Maccallum Cancer Center; University of Melbourne; Peter Maccallum Cancer Center; Stanford University; University of Western Australia; University of Western Australia; The Kids Research Institute Australia; La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; University of Melbourne; University of Melbourne; Peter Doherty Institute; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; Melbourne Health; Royal Melbourne Hospital; Monash University
摘要：The efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumours is limited by immunosuppression and antigen heterogeneity1, 2-3. To overcome these barriers, 'armoured' CAR T cells, which secrete proinflammatory cytokines, have been developed4. However, their clinical application has been limited because of toxicity related to peripheral expression of the armouring transgene5. Here, we have developed a CRISPR knock-in strategy that leverages the regulatory mechanisms of endogeno...
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作者：Zeng, Tian Chen; Vyazov, Leonid A.; Kim, Alexander; Flegontov, Pavel; Sirak, Kendra; Maier, Robert; Lazaridis, Iosif; Akbari, Ali; Frachetti, Michael; Tishkin, Alexey A.; Ryabogina, Natalia E.; Agapov, Sergey A.; Agapov, Danila S.; Alekseev, Anatoliy N.; Boeskorov, Gennady G.; Derevianko, Anatoly P.; Dyakonov, Viktor M.; Enshin, Dmitry N.; Fribus, Alexey V.; Frolov, Yaroslav V.; Grushin, Sergey P.; Khokhlov, Alexander A.; Kiryushin, Kirill Yu.; Kiryushin, Yurii F.; Kitov, Egor P.; Kosintsev, Pavel; Kovtun, Igor V.; Makarov, Nikolai P.; Morozov, Viktor V.; Nikolaev, Egor N.; Rykun, Marina P.; Savenkova, Tatyana M.; Shchelchkova, Marina V.; Shirokov, Vladimir; Skochina, Svetlana N.; Sherstobitova, Olga S.; Slepchenko, Sergey M.; Solodovnikov, Konstantin N.; Solovyova, Elena N.; Stepanov, Aleksandr D.; Timoshchenko, Aleksei A.; Vdovin, Aleksandr S.; Vybornov, Anton V.; Balanovska, Elena V.; Dryomov, Stanislav; Hellenthal, Garrett; Kidd, Kenneth; Krause, Johannes; Starikovskaya, Elena; Sukernik, Rem; Tatarinova, Tatiana; Thomas, Mark G.; Zhabagin, Maxat; Callan, Kim; Cheronet, Olivia; Fernandes, Daniel; Keating, Denise; Candilio, Francesca; Iliev, Lora; Kearns, Aisling; Oezdogan, Kadir Toykan; Mah, Matthew; Micco, Adam; Michel, Megan; Olalde, Inigo; Zalzala, Fatma; Mallick, Swapan; Rohland, Nadin; Pinhasi, Ron; Narasimhan, Vagheesh M.; Reich, David
作者单位：Harvard University; University of Ostrava; Harvard University; Harvard Medical School; Harvard University; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Washington University (WUSTL); Washington University (WUSTL); Altai State University; University of Gothenburg; Russian Academy of Sciences; Diamond & Precious Metal Geology Institute Siberian Branch of Russian Academy of Sciences; Russian Academy of Sciences; Russian Academy of Sciences; Institute of Archaeology & Ethnography, Siberian Branch of Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; Russian Academy of Sciences; Tyumen Scientific Center of the Russian Academy of Sciences; Russian Academy of Sciences; Institute for the History of Material Culture, Russian Academy of Sciences; Samara State University of Social Sciences & Education; Altai State University; Russian Academy of Sciences; N.N. Miklukho-Maklai Institute of Ethnology & Anthropology; Russian Academy of Sciences; Institute of Plant & Animal Ecology of the Russian Academy of Sciences; Ural Federal University; Tomsk State University; Krasnoyarsk State Medical University; North-Eastern Federal University in Yakutsk; Russian Academy of Sciences; Institute of History & Archaeology of the Ural Branch of the Russian Academy of Sciences; Research Centre for Medical Genetics; Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; University of London; University College London; Yale University; Max Planck Society; University of La Verne; Nazarbayev University; National Center for Biotechnology (NCB); Howard Hughes Medical Institute; Harvard University; Harvard Medical School; University of Vienna; University of Vienna; Universidade de Coimbra; University College Dublin; Utrecht University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Basque Country; Basque Foundation for Science; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：The North Eurasian forest and forest-steppe zones have sustained millennia of sociocultural connections among northern peoples, but much of their history is poorly understood. In particular, the genomic formation of populations that speak Uralic and Yeniseian languages today is unknown. Here, by generating genome-wide data for 180 ancient individuals spanning this region, we show that the Early-to-Mid-Holocene hunter-gatherers harboured a continuous gradient of ancestry from fully European-rel...
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作者：Banks, William E.
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux
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作者：Marrs, Kathleen A.
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作者：Berreur, Jordan; Watts, Olivia F. B.; Bulless, Theo H. N.; O'Donoghue, Nicholas T.; Del Olmo, Marc; Winter, Ashley J.; Clayden, Jonathan; Collins, Beatrice S. L.
作者单位：University of Bristol
摘要：Living biological systems rely on the continuous operation of chemical reaction networks. These networks sustain out-of-equilibrium regimes in which chemical energy is continually converted into controlled mechanical work and motion1, 2-3. Out-of-equilibrium reaction networks have also enabled the design and successful development of artificial autonomously operating molecular machines4,5, in which networks comprising pairs of formally-but non-microscopically-reverse reaction pathways drive co...
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作者：Diaz-Gay, Marcos; Zhang, Tongwu; Hoang, Phuc H.; Leduc, Charles; Baine, Marina K.; Travis, William D.; Sholl, Lynette M.; Joubert, Philippe; Khandekar, Azhar; Zhao, Wei; Steele, Christopher D.; Otlu, Burcak; Nandi, Shuvro P.; Vangara, Raviteja; Bergstrom, Erik N.; Kazachkova, Mariya; Pich, Oriol; Swanton, Charles; Hsiung, Chao Agnes; Chang, I-Shou; Wong, Maria Pik; Leung, Kin Chung; Sang, Jian; McElderry, John P.; Hartman, Caleb; Colon-Matos, Frank J.; Miraftab, Mona; Saha, Monjoy; Lee, Olivia W.; Jones, Kristine M.; Gallego-Garcia, Pilar; Yang, Yang; Zhong, Xiaoming; Edell, Eric S.; Santamaria, Jacobo Martinez; Schabath, Matthew B.; Yendamuri, Sai S.; Manczuk, Marta; Lissowska, Jolanta; Swiatkowska, Beata; Mukeria, Anush; Shangina, Oxana; Zaridze, David; Holcatova, Ivana; Mates, Dana; Milosavljevic, Sasa; Kontic, Millica; Bosse, Yohan; Rothberg, Bonnie E. Gould; Christiani, David C.; Gaborieau, Valerie; Brennan, Paul; Liu, Geoffrey; Hofman, Paul; Yang, Lixing; Nowak, Martin A.; Shi, Jianxin; Rothman, Nathaniel; Wedge, David C.; Homer, Robert; Yang, Soo-Ryum; Pesatori, Angela C.; Consonni, Dario; Lan, Qing; Zhu, Bin; Chanock, Stephen J.; Choi, Jiyeon; Alexandrov, Ludmil B.; Landi, Maria Teresa
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Centro Nacional de Investigaciones Oncologicas (CNIO); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics; Universite de Montreal; Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Laval University; Laval University Hospital; Middle East Technical University; Francis Crick Institute; University of London; University College London; Cancer Research UK; National Health Research Institutes - Taiwan; National Health Research Institutes - Taiwan; University of Hong Kong; University of Hong Kong; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Chicago; Mayo Clinic; H Lee Moffitt Cancer Center & Research Institute; Roswell Park Comprehensive Cancer Center; Nofer Institute of Occupational Medicine; Motol University Hospital; Charles University Prague; Charles University Prague; Motol University Hospital; Motol University Hospital; Clinical Centre of Serbia; University of Belgrade; University of Miami; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; World Health Organization; International Agency for Research on Cancer (IARC); University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Universite Cote d'Azur; University of Chicago; Robert H. Lurie Comprehensive Cancer Center; University of Chicago; Harvard University; Harvard University; University of Manchester; University of Manchester; Yale University; University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; University of California System; University of California San Diego
摘要：Lung cancer in never smokers (LCINS) accounts for around 25% of all lung cancers1,2 and has been associated with exposure to second-hand tobacco smoke and air pollution in observational studies3, 4-5. Here we use data from the Sherlock-Lung study to evaluate mutagenic exposures in LCINS by examining the cancer genomes of 871 treatment-naive individuals with lung cancer who had never smoked, from 28 geographical locations. KRAS mutations were 3.8 times more common in adenocarcinomas of never sm...
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作者：Huo, Jingfeng; Fu, Yue; Tang, Melody J.; Su, Ya; Hu, Shengkun; Liu, Peng; Dong, Guangbin
作者单位：University of Chicago; Merck & Company; Merck & Company USA; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Aromatic rings, also known as arenes, containing two or more adjacent different substituents are ubiquitously found in small-molecule drugs1. Strategies that can rapidly introduce diverse vicinal substituents to readily available precursors would greatly benefit the generation of analogues of biologically active compounds2, which, however, remain challenging to realize so far. The existing approaches for preparing vicinal difunctionalized arenes lack modularity, regioselectivity or generality....
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作者：Callaway, Ewen
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作者：Liao, Hongguang; Hu, Sheng; Yang, Hu; Wang, Lei; Tanaka, Shinya; Takigawa, Ichigaku; Li, Wei; Fan, Hailong; Gong, Jian Ping
作者单位：Hokkaido University; Hokkaido University; University of Osaka; Central University of Finance & Economics; Hokkaido University; Kyoto University; Suzhou Laboratory; Hokkaido University; Shenzhen University
摘要：Data-driven methodologies have transformed the discovery and prediction of hard materials with well-defined atomic structures by leveraging standardized datasets, enabling accurate property predictions and facilitating efficient exploration of design spaces1, 2-3. However, their application to soft materials remains challenging because of complex, multiscale structure-property relationships4, 5-6. Here we present a data-driven approach that integrates data mining, experimentation and machine l...
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作者：Mallapaty, Smriti
