作者：Jay, Ollie; Vanos, Jennifer; Gagnon, Daniel; Tartarini, Federico
作者单位：University of Sydney; Arizona State University; Arizona State University-Downtown Phoenix; Universite de Montreal; Laval University; Universite de Montreal
作者：Agudelo Rueda, Jeffersson
作者单位：Northumbria University
作者：Sharma, Sonali; Rodems, Benjamin J.; Baker, Cameron D.; Kaszuba, Christina M.; Franco, Edgardo I.; Smith, Bradley R.; Ito, Takashi; Swovick, Kyle; Welle, Kevin; Zhang, Yi; Rock, Philip; Chaves, Francisco A.; Ghaemmaghami, Sina; Calvi, Laura M.; Ganguly, Archan; Burack, W. Richard; Becker, Michael W.; Liesveld, Jane L.; Brookes, Paul S.; Munger, Joshua C.; Jordan, Craig T.; Ashton, John M.; Bajaj, Jeevisha
作者单位：University of Rochester; University of Rochester; University of Rochester; University of Rochester; University of Rochester; Fukui Prefectural University; University of Rochester; University of Rochester; University of Rochester; University of Rochester; University of Rochester; University of Rochester; University of Colorado System; University of Colorado Anschutz Medical Campus
摘要：Signals from the microenvironment are known to be critical for development, stem cell self-renewal and oncogenic progression. Although some niche-driven signals that promote cancer progression have been identified1, 2, 3, 4-5, concerted efforts to map disease-relevant microenvironmental ligands of cancer stem cell receptors have been lacking. Here, we use temporal single-cell RNA-sequencing (scRNA-seq) to identify molecular cues from the bone marrow stromal niche that engage leukaemia stem-enr...
作者：Lassalle, Geraldine; Lambert, Patrick; Darnaude, Audrey M.; de Almeida, Pedro Raposo
作者单位：INRAE; University of Evora
作者：Yang, Yang; Sai, Hiroaki; Egner, Simon A.; Qiu, Ruomeng; Palmer, Liam C.; Stupp, Samuel I.
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
