作者：Lamprecht, Dirk A.; Wall, Richard J.; Leemans, Annelies; Truebody, Barry; Sprangers, Joke; Fiogbe, Patricia; Davies, Cadi; Wetzel, Jennefer; Daems, Stijn; Pearson, William; Pillay, Vanessa; Saylock, Samantha; Ricketts, M. Daniel; Davis, Ellie; Huff, Adam; Grell, Tsehai; Lin, Shiming; Gerber, Michelle; Vos, Ann; Dallow, John; Willcocks, Sam J.; Roubert, Christine; Sans, Stephanie; Desorme, Amandine; Chappat, Nicolas; Ray, Aurelie; Pereira Moraes, Mariana; Washington, Tracy; D'Erasmo, Hope; Sancheti, Pavankumar; Everaerts, Melissa; Monshouwer, Mario; Esquivias, Jorge; Larrouy-Maumus, Gerald; Draghia Akli, Ruxandra; Fletcher, Helen; Pym, Alexander S.; Aldridge, Bree B.; Sarathy, Jansy P.; Clancy, Kathleen W.; Stoops, Bart; Dhar, Neeraj; Steyn, Adrie J. C.; Jackson, Paul; Aguilar-Perez, Clara; Koul, Anil
作者单位：Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals; University of London; London School of Hygiene & Tropical Medicine; Africa Health Research Institute; University of Kwazulu Natal; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Janssen Pharmaceuticals; University of Saskatchewan; Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals; Tufts University; Johnson & Johnson; Janssen Pharmaceuticals; Imperial College London; Johnson & Johnson; Janssen Pharmaceuticals; Tufts University; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; Johnson & Johnson; Janssen Pharmaceuticals; Johnson & Johnson USA; University of Cape Town; Brunel University
摘要：Tuberculosis remains the leading cause of death from an infectious disease1,2. Here we report the discovery of a first-in-class small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway. The lead candidate, JNJ-6640, exhibited nanomolar bactericidal activity in vitro. Comprehensive genetic and biochemical approaches confirmed that JNJ-6640 was highly selective for mycobacterial PurF. Single-cell-level microscopy demonstrated a downstream...
作者：Gabriel, Iason; Keeling, Geoff; Manzini, Arianna; Evans, James
作者单位：Alphabet Inc.; Google Incorporated; DeepMind; University of Chicago
摘要：The deployment of capable AI agents raises fresh questions about safety, human-machine relationships and social coordination.
作者：Luo, Zaili; Xia, Mingyang; Shi, Wei; Zhao, Chuntao; Wang, Jiajia; Xin, Dazhuan; Dong, Xinran; Xiong, Yu; Zhang, Feng; Berry, Kalen; Ogurek, Sean; Liu, Xuezhao; Rao, Rohit; Xing, Rui; Wu, Lai Man Natalie; Cui, Siying; Xu, Lingli; Lin, Yifeng; Ma, Wenkun; Tian, Shuaiwei; Xie, Qi; Zhang, Li; Xin, Mei; Wang, Xiaotao; Yue, Feng; Zheng, Haizi; Liu, Yaping; Stevenson, Charles B.; de Blank, Peter; Perentesis, John P.; Gilbertson, Richard J.; Li, Hao; Ma, Jie; Zhou, Wenhao; Taylor, Michael D.; Lu, Q. Richard
作者：Rahwan, Iyad; Shariff, Azim; Bonnefon, Jean-Francois
作者单位：Max Planck Society; University of British Columbia; Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics
摘要：Predicting the social and behavioural impact of future technologies before they are achieved would enable us to guide their development and regulation before these impacts get entrenched. Traditionally, this prediction has relied on qualitative, narrative methods. Here we describe a method that uses experimental methods to simulate future technologies and collect quantitative measures of the attitudes and behaviours of participants assigned to controlled variations of the future. We call this ...
