8075期

最新文章

• The role of metabolism in shaping enzyme structures over 400 million years AI翻译
  作者：Lemke, Oliver; Heineike, Benjamin Murray; Viknander, Sandra; Cohen, Nir; Li, Feiran; Steenwyk, Jacob Lucas; Spranger, Leonard; Agostini, Federica; Lee, Cory Thomas; Aulakh, Simran Kaur; Berman, Judith; Rokas, Antonis; Nielsen, Jens; Gossmann, Toni Ingolf; Zelezniak, Aleksej; Ralser, Markus
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Oxford; Wellcome Centre for Human Genetics; Francis Crick Institute; Chalmers University of Technology; Howard Hughes Medical Institute; University of California System; University of California Berkeley; Vanderbilt University; University of California System; University of California Berkeley; Vanderbilt University; Tel Aviv University; Dortmund University of Technology; Vilnius University; University of London; King's College London; Max Planck Society
  摘要：Advances in deep learning and AlphaFold2 have enabled the large-scale prediction of protein structures across species, opening avenues for studying protein function and evolution1. Here we analyse 11,269 predicted and experimentally determined enzyme structures that catalyse 361 metabolic reactions across 225 pathways to investigate metabolic evolution over 400 million years in the Saccharomycotina subphylum2. By linking sequence divergence in structurally conserved regions to a variety of met...
• Data anomalies and the economic commitment of climate change AI翻译
  作者：Bearpark, Tom; Hogan, Dylan; Hsiang, Solomon
  作者单位：Princeton University; Columbia University; Stanford University; National Bureau of Economic Research
• Inconclusive proof of ferroelectricity in peptide-VDF ribbons AI翻译
  作者：Litterst, Maximilian; Butkevich, Andrey Alekseevich; Kemerink, Martijn
  作者单位：Ruprecht Karls University Heidelberg
• Stress dynamically modulates neuronal autophagy to gate depression onset ( vol 641, pages427-437 , 2025) AI翻译
  作者：Yang, Liang; Guo, Chen; Zheng, Zhiwei; Dong, Yiyan; Xie, Qifeng; Lv, Zijian; Li, Min; Lu, Yangyang; Guo, Xiaonan; Deng, Rongshan; Liu, Yiqin; Feng, Yirong; Mu, Ruiqi; Zhang, Xuliang; Ma, Huan; Chen, Zhong; Zhang, Zhijun; Dong, Zhaoqi; Yang, Wei; Zhang, Xiangnan; Cui, Yihui
• Breed giant prawns to withstand disease and climate change AI翻译
  作者：Li, Fengbo; Gao, Qiang
• HOW THIS SCIENTIST BECAME A RESEARCH-INTEGRITY SLEUTH AI翻译
  作者：Ro, Christine
• The tiny mouse lemur could make for a mighty model organism AI翻译
  作者：Camp, J. Gray
  作者单位：Roche Holding; University of Basel
• Invariance of dynamo action in an early-Earth model AI翻译
  作者：Lin, Yufeng; Marti, Philippe; Jackson, Andrew
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Magnetic field generation on Earth has probably persisted for at least 3.5 Gyr (refs. 1,2), initially sustained by secular cooling of the Earth's core and, more recently, by the growth of the solid inner core3. Numerical models of the present-day geodynamo have proved to be successful in producing Earth-like magnetic fields4, 5, 6-7 and approaching realistic dynamic regimes8, 9, 10-11. However, thermal evolution12,13 and palaeomagnetic records14,15 suggest that the geodynamo operated for most ...
• 'The Sun had fallen to Earth' - a survivor's recollection of the Hiroshima bombing AI翻译
  作者：Sheftall, Mordecai
• Where I workErasto Job AI翻译
  作者：Forrester, Nikki