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作者：Hoover, Gregory; Gilbert, Shila; Curley, Olivia; Obellianne, Clemence; Lin, Mike T.; Hixson, William; Pierce, Terry W.; Andrews, Joel F.; Alexeyev, Mikhail F.; Ding, Yi; Bu, Ping; Behbod, Fariba; Medina, Daniel; Chang, Jeffrey T.; Ayala, Gustavo; Grelet, Simon
作者单位：University of South Alabama; University of South Alabama; University of South Alabama; University of South Alabama; University of Texas System; University of Texas Health Science Center Houston; University of Kansas; University of Kansas Medical Center; Baylor College of Medicine; University of Texas System; University of Texas Health Science Center Houston
摘要：The nervous system has a pivotal role in cancer biology, and pathological investigations have linked intratumoural nerve density to metastasis1. However, the precise impact of cancer-associated neurons and the communication channels at the nerve-cancer interface remain poorly understood. Previous cancer denervation models in rodents and humans have highlighted robust cancer dependency on nerves, but the underlying mechanisms that drive nerve-mediated cancer aggressivity remain unknown2,3. Here...
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作者：Lee, John H.; Sergeeva, Alina P.; Ahlsen, Goran; Mannepalli, Seetha; Bahna, Fabiana; Goodman, Kerry M.; Xu, Runzhe; Khakh, Baljit S.; Weiner, Joshua A.; Shapiro, Lawrence; Honig, Barry; Zipursky, S. Lawrence
作者单位：University of California System; University of California Los Angeles; Columbia University; Columbia University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Iowa; University of Iowa; Columbia University; Columbia University
摘要：Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance1, 2, 3-4. Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development5, 6-7. The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to ...
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作者：Qian, Xuyu; Coleman, Kyle; Jiang, Shunzhou; Kriz, Andrea J.; Marciano, Jack H.; Luo, Chunyu; Cai, Chunhui; Manam, Monica Devi; Caglayan, Emre; Lai, Abbe; Exposito-Alonso, David; Otani, Aoi; Ghosh, Urmi; Shao, Diane D.; Andersen, Rebecca E.; Neil, Jennifer E.; Johnson, Robert; LeFevre, Alexandra; Hecht, Jonathan L.; Micali, Nicola; Sestan, Nenad; Rakic, Pasko; Miller, Michael B.; Sun, Liang; Stringer, Carsen; Li, Mingyao; Walsh, Christopher A.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University System of Maryland; University of Maryland Baltimore; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Yale University; Yale University; Yale University; Yale University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：The human cerebral cortex is composed of six layers and dozens of areas that are molecularly and structurally distinct1, 2, 3-4. Although single-cell transcriptomic studies have advanced the molecular characterization of human cortical development, a substantial gap exists owing to the loss of spatial context during cell dissociation5, 6, 7-8. Here we used multiplexed error-robust fluorescence in situ hybridization (MERFISH)9, augmented with deep-learning-based nucleus segmentation, to examine...
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作者：Sharples, Jason
作者单位：University of New South Wales Sydney
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作者：[Anonymous]
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作者：Ahart, Jenna; Witze, Alexandra
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作者：[Anonymous]
