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• Design of intrinsically disordered region binding proteins AI翻译
  作者：Wu, Kejia; Jiang, Hanlun; Hicks, Derrick R.; Liu, Caixuan; Muratspahic, Edin; Ramelot, Theresa A.; Liu, Yuexuan; McNally, Kerrie; Kenny, Sebastian; Mihut, Andrei; Gaur, Amit; Coventry, Brian; Chen, Wei; Bera, Asim K.; Kang, Alex; Gerben, Stacey; Lamb, Mila Ya-Lan; Murray, Analisa; Li, Xinting; Kennedy, Madison A.; Yang, Wei; Song, Zihao; Schober, Gudrun; Brierley, Stuart M.; O'Neill, John; Gelb, Michael H.; Montelione, Gaetano T.; Derivery, Emmanuel; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Rensselaer Polytechnic Institute; University of Washington; University of Washington Seattle; MRC Laboratory Molecular Biology; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; South Australian Health & Medical Research Institute (SAHMRI); University of Adelaide
  摘要：Intrinsically disordered proteins and peptides play key roles in biology, but a lack of defined structures and high variability in sequence and conformational preferences have made targeting such systems challenging. We describe a general approach for designing proteins that bind intrinsically disordered protein regions in diverse extended conformations with side chains fitting into complementary binding pockets. We used the approach to design binders for 39 highly diverse unstructured targets...
• Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense AI翻译
  作者：Barilla, Rocky M.; Berard, Clara; Sun, Linyu; Sandhu, Sumiti; Zaghouani, Sarah; Iyer, Krishna S.; Altun, Gizem; Su, Chien-Wen; Deguine, Jacques; Singh, Vasundhara; Hou, Yu; Kusumakar, Kanupriya; Rutlin, Michael L.; Rao, Meenakshi; Zaghouani, Habib; Shi, Hai Ning; Xavier, Ramnik J.; Kuchroo, Vijay K.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Minnesota System; University of Minnesota Twin Cities; Technical University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Liangzhu Laboratory; Zhejiang University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Missouri System; University of Missouri Columbia; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Enteric nervous system (ENS)-derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is considerably lacking. Here, we characterized a primary enteric sensory neuron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide beta (CGRP beta) and coexpressing receptors for the type 2 cytokines interleukin-4 (IL-4) and IL-13. Type 2 cytokines amplified NMU...
• Skeletal editing of pyrrolidines by nitrogen-atom insertion AI翻译
  作者：Li, Jinghao; Tang, Pengcheng; Fan, Yang; Lu, Hongjian
  作者单位：Guizhou University; Nanjing University
  摘要：Given the prevalence of nitrogen-containing heterocycles in bioactive molecules, inserting a nitrogen atom into a saturated ring offers a powerful yet underdeveloped scaffold-hopping strategy for expanding drug-like chemical space. In this study, we present a skeletal editing method that directly inserts a nitrogen atom into pyrrolidine rings, converting them into tetrahydropyridazine scaffolds under mild, operationally simple conditions with readily available O-diphenylphosphinyl hydroxylamin...
• The pursuit of 1.5°C endures as a legal and ethical imperative in a changing world AI翻译
  作者：Rogelj, Joeri; Rajamani, Lavanya
  作者单位：Imperial College London; Imperial College London; International Institute for Applied Systems Analysis (IIASA); University of Oxford; University of Oxford
• Science philanthropy faces a new reality AI翻译
  作者：Falk, Adam
  作者单位：Wildlife Conservation Society
• US should reject color-blind racial ideology AI翻译
  作者：Russo-Tait, Tatiane; Blanco, Summer; Bonilla-Silva, Eduardo
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Duke University
• Controlled colonization of the human gut with a genetically engineered microbial therapeutic AI翻译
  作者：Whitaker, Weston R.; Russ, Zachary N.; Stanley Shepherd, Elizabeth; Popov, Lauren M.; Louie, Alexander; Lam, Kathy; Zong, David M.; Gill, Clare C. C.; Gehrig, Jeanette L.; Rishi, Harneet S.; Tan, Jessica A.; Buness, Areta; Godoy, Janeth; Banta, Domenique; Jaidka, Sonia; Wilson, Katheryne; Flood, Jake; Bukshpun, Polina; Yocum, Richard; Cook, David N.; Warsi, Tariq; Mclean, Lachy; Sonnenburg, Justin L.; Deloache, William C.
  作者单位：Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University
  摘要：Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to engraft engineered bacteria into diverse microbiota in mice by using a porphyran prebiotic. Building on this approach, we have now engineered conditional attenuation into a porphyran-utilizing strain of Phocaeicola vulgatus by replacing native essential gene regulation with a porphyran-inducible promoter...
• Stigma did not kill my dream AI翻译
  作者：Cambronero-Heinrichs, Juan Carlos
  作者单位：University of Padua
• US cancels hunt for signs of cosmic inflation AI翻译
  作者：Cho, Adrian
• Astronomers race to study third known interstellar interloper AI翻译
  作者：Mann, Adam