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作者：Tabatabaeian, Shadab; O'bi, Artemisia; Landy, David; Marghetis, Tyler
作者单位：University of California System; University of California Merced; Indiana University System; Indiana University Bloomington; Netflix, Inc.
摘要：The eureka insights that drive progress in science and mathematics remain shrouded in mystery. Sudden, unexpected, appearing like flashes of lightning, these insights have the hallmarks of critical transitions in complex systems. Here, zooming in on mathematicians working on proofs in their own departments, we show that sudden insights are anticipated by a system-agnostic, information-theoretic early warning signal. Using dense behavioral recordings of mathematicians' moment-to-moment activity...
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作者：Urda-Garciaa, Beatriz; Sanchez-Valle, Jon; Lepore, Rosalba; Valencia, Alfonso
作者单位：Universitat Politecnica de Catalunya; Barcelona Supercomputer Center (BSC-CNS); Pompeu Fabra University; University of Basel; University of Basel; ICREA
摘要：Epidemiological evidence shows that some diseases tend to co-occur; more exactly, certain groups of patients with a given disease are at a higher risk of developing a specific secondary condition. Here, we develop an approach to generate a disease network that uses the accumulating RNA-seq data on human diseases to significantly match an unprecedented proportion of known comorbidities, providing plausible biological models for such co-occurrences and effectively mirroring the underlying struct...
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作者：Amarathunga, Udara; Brocks, Jochen J.; Meijer, Paul Th.; Hope, Janet M.; Zachariasse, Willem-Jan; Hennekam, Rick; van der Hoeven, Isabel; Roehl, Ursula; Rule, Susan; Troitzsch, Ulrike; Haberle, Simon; Sluijs, Appy; Grant, Katharine M.; Krijgsman, Wout; Garcia-Castellanos, Daniel; Hogg, Andrew McC.; Reichart, Gert-Jan; Roberts, Andrew P.; Rohling, Eelco J.
作者单位：Princeton University; Australian National University; Utrecht University; University of Bremen; Australian National University; Australian National University; Australian National University; Consejo Superior de Investigaciones Cientificas (CSIC); Australian National University
摘要：The Mediterranean basin reconnected to the Atlantic Ocean similar to 5.33 Myr ago, following its partial desiccation during the preceding Messinian salinity crisis (5.97 to 5.33 Myr). While the extent of terminal Messinian drawdown and abruptness of reconnection are debated, recent work inferred that an anomalously long-lasting eastern Mediterranean organic-rich mystery sapropel layer was deposited due to salinity-stratification and anoxia following catastrophic flooding that refilled the basi...
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作者：Wang, Changming; Ji, Haiwang; Wang, Hanwen; Chen, Ziyun; Zhou, Lan; Yang, Yan; Jiang, Yucui; Yu, Guang; Jiang, Ling; Tang, Zongxiang
作者单位：Nanjing University of Chinese Medicine; Nanjing University of Chinese Medicine; Nanjing Medical University
摘要：Cancer- induced bone pain (CIBP) is a severely painful condition that profoundly impacts patients' quality of life. However, the neuroimmune mechanisms underlying CIBP remain largely elusive. Substance P (SP), which is known to play a pivotal role in pain perception, became the focal point of our study. To this end, we adopted a comprehensive approach combining behavioral and physiological methods to investigate its role in neuroimmune interactions in CIBP. The results showed that SP released ...
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作者：Xie, Ting; Lin, Da; Cai, Xing-Da; Ma, Li-Juan; Wang, Lu; Cai, Tian-Gui; Ye, Yu-Qiu; Shen, Luo-Qin; Sun, Ming-Ming; Ye, Mao; Neilson, Roy; Zhu, Dong
作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hebei University; Nanjing Agricultural University; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; James Hutton Institute
摘要：Biochar amendment reshapes microbial community dynamics in vermicomposting, but the mechanism of how phages respond to this anthropogenic intervention and regulate the dissemination of antibiotic resistance genes (ARGs) remains unclear. In this study, we used metagenomics, viromics, and laboratory validation to explore how nano- biochar affects phage-host interactions and ARGs dissemination in vermicomposting. Our results revealed distinct niche- specific phage life strategies. In vermicompost...
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作者：Wynn, Jordana S.; Khosla, Anisha; Kacollja, Arber; Shahmiri, Elaheh; Anderson, Nicole D.; Shen, Kelly; Ryan, Jennifer D.
作者单位：University of Victoria; University of Toronto; Baycrest; University of Toronto; Vector Institute for Artificial Intelligence; University of Toronto; Simon Fraser University
摘要：Eye movements are closely linked to encoding and retrieval processes, with changes in viewing behavior reflecting age-and pathology-related memory decline. In the current study, we leveraged this relationship to explore possible gaze-based indicators of memory function. Across two task-free viewing experiments, we investigated changes in naturalistic viewing behavior across five participant groups spanning a broad spectrum of memory function, from healthy young adults to amnesic cases. We show...
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作者：Elser, James J.; Klip, Helena C. L.
作者单位：University of Montana System; University of Montana
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作者：Chau, Ho Yin; Miller, Kenneth D.; Palmigiano, Agostina
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; University of London; University College London
摘要：What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of single cells in the mouse primary visual cortex. A robust theoretical framework is needed to determine the implications of these responses for cortical recurrence. Here, we propose a formulation of the dependence of cell-ty...
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作者：Park, Seung Kuk; Guo, Mo; Stamos, Jennifer L.; Kim, Wantae; Lee, Sidae; Zhang, Y. Jessie; Lambowitz, Alan M.
作者单位：Stanford Cancer Institute; Stanford University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：A previous study found that a bacterial group II intron-like reverse transcriptase (G2L4 RT) evolved to function in double-strand break repair (DSBR) via microhomology-mediated end-joining (MMEJ) and that a mobile group II intron-encoded RT has a basal DSBR activity that uses conserved structural features of non-long terminal repeat (non-LTR)-retroelement RTs. Here, we determined G2L4 RT apoenzyme and snap-back DNA synthesis structures revealing unique structural adaptations that optimized its...
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作者：Roy, Ethan
作者单位：Stanford University
