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作者：Joyce, Theodore
作者单位：City University of New York (CUNY) System; Baruch College (CUNY); National Bureau of Economic Research; City University of New York (CUNY) System; Baruch College (CUNY)
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作者：Mathis, Diane
作者单位：Harvard University; Harvard Medical School
摘要：The 2024 Albert Lasker Basic Medical Research Award was attributed to Zhijian (James) Chen for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses. Bringing to bear an ingenious in vitro complementation system, an astute insight, and superlative biochemistry, Chen and colleagues identified cGAS (cGAMP synthase) as both the molecule that perceives cytosolic DNA in infected, stressed, or dying cells and th...
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作者：Fu, Chaoyu; Dilasser, Florian; Lin, Shao-Zhen; Karnat, Marc; Arora, Aditya; Rajendiran, Harini; Ong, Hui Ting; Brenda, Nai Mui Hoon; Phow, Sound Wai; Hirashima, Tsuyoshi; Sheetz, Michael; Rupprecht, Jean-Francois; Tlili, Sham; Viasnoff, Virgile
作者单位：National University of Singapore; Aix-Marseille Universite; Universite de Toulon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); National University of Singapore; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
摘要：Collective cell migration is crucial in various physiological processes, including wound healing, morphogenesis, and cancer metastasis. Adherens Junctions (AJs) play a pivotal role in regulating cell cohesion and migration dynamics during tissue remodeling. While the role and origin of the junctional mechanical tension at AJs have been extensively studied, the influence of the actin cortex structure and dynamics on junction plasticity remains incompletely understood. Moreover, the mechanisms u...
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作者：DeTomaso, Angela; Kim, Hyeyon; Shauh, Jacqueline; Adulla, Anika; Zigo, Sarah; Ghoul, Maya; Presicce, Pietro; Kallapur, Suhas G.; Goodman, Wendy; Tilburgs, Tamara; Way, Sing-Sing; Hackney, David; Moore, John; Mesiano, Sam
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作者：Hu, Yizong; Tzeng, Stephany Y.; Cheng, Leonardo; Lin, Jinghan; Villabona-Rueda, Andres; Yu, Shuai; Li, Sixuan; Schneiderman, Zachary; Zhu, Yining; Ma, Jingyao; Wilson, David R.; Shannon, Sydney R.; Warren, Tiarra; Rui, Yuan; Qiu, Chenhu; Kavanagh, Erin W.; Luly, Kathryn M.; Zhang, Yicheng; Korinetz, Nicole; D'Alessio, Franco R.; Wang, Tza-Huei; Kokkoli, Efrosin; Reddy, Sashank K.; Luijten, Erik; Green, Jordan J.; Mao, Hai-Quan
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Northwestern University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Northwestern University; Northwestern University; Northwestern University; Massachusetts Institute of Technology (MIT)
摘要：Size- dependent phagocytosis is a well- characterized phenomenon in monocytes and macrophages. However, this size effect for preferential gene delivery to these important cell targets has not been fully exploited because commonly adopted stabilization methods for electrostatically complexed nucleic acid nanoparticles, such as PEGylation and charge repulsion, typically arrest the vehicle size below 200 nm. Here, we bridge the technical gap in scalable synthesis of larger submicron gene delivery...
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作者：Mehta, Kritika; Yentsch, Henry; Lee, Jungbin; Yook, Yeeun; Lee, Kwan Young; Gao, Tianyu Terry; Tsai, Nien-Pei; Zhang, Kai
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Activity- regulated cytoskeleton- associated protein (Arc/Arg3.1) is an immediate early gene that plays a vital role in learning and memory. Arc protein has structural and functional properties similar to viral Group- specific antigen (Gag) protein and mediates the intercellular RNA transfer through virus- like capsids. However, the regulators and secretion pathway through which Arc capsids maneuver cargos are unclear. Here, we identified that phosphatidylinositol-3- phosphate (PI3P) mediates ...
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作者：Foley, K. Grace; Adli, Mazhar; Kim, J. Julie
作者单位：Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center
摘要：Significant racial disparities exist between Black and White patients with uterine serous carcinoma (USC). While the reasons for these disparities are unclear, several studies have demonstrated significantly different rates of driver mutations between racial groups, including TP53. However, limited research has investigated the transcriptional differences of tumors or the composition of the tumor microenvironment (TME) between these groups. Here, we report the single- nuclei RNA- sequencing pr...
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作者：Hou, William C.; Massey, Lynee A.; Rhoades, Derek; Wu, Yin; Ren, Wen; Frank, Chiara; Overkleeft, Herman S.; Kelly, Jeffrey W.
作者单位：Scripps Research Institute; Scripps Research Institute; Leiden University - Excl LUMC; Leiden University
摘要：Lysosomal degradation pathways coordinate the clearance of superfluous and damaged cellular components. Compromised lysosomal degradation is a hallmark of many degenerative diseases, including lysosomal storage diseases (LSDs), which are caused by loss- of- function mutations within both alleles of a lysosomal hydrolase, leading to lysosomal substrate accumulation. Gaucher's disease, characterized by <15% of normal glucocerebrosidase function, is the most common LSD and is a prominent risk fac...
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作者：Liang, Shuang; Wu, Qi; Wang, Changhua; Wang, Rui; Li, Dashuai; Xing, Yanmei; Jin, Dexin; Ma, He; Liu, Yichun; Zhang, Peng; Zhang, Xintong
作者单位：Northeast Normal University - China; Dalhousie University
摘要：Clean production of hydrogen peroxide (H2O2) with water, oxygen, and renewable energy is considered an important green synthesis route, offering a valuable substitute for the traditional anthraquinone method. Currently, renewable energy-driven production of H2O2 mostly relies on soluble additives, such as electrolytes and sacrificial agents, inevitably compromising the purity and sustainability of H2O2. Herein, we develop a solution plasma catalysis technique that eliminates the need for solub...
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作者：Diercks, Alan H.; Podolskaia, Irina S.; Murray, Tara A.; Jahn, Ana N.; Mai, Dat; Liu, Dong; Amon, Lynn M.; Nakagawa, Yoshimi; Shimano, Hitoshi; Aderem, Alan; Gold, Elizabeth S.
作者单位：Seattle Children's Hospital; University of Tsukuba; University of Tsukuba; University of Tsukuba
摘要：Toll- like receptors (TLRs) on macrophages sense microbial components and trigger the production of numerous cytokines and chemokines that mediate the inflammatory response to infection. Although many of the components required for the activation of the TLR pathway have been identified, the mechanisms that appropriately regulate the magnitude and duration of the response and ultimately restore homeostasis are less well understood. Furthermore, a growing body of work indicates that TLR signalin...
