Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Physical modeling of nucleosome clustering in euchromatin resulting from interactions between epigenetic reader proteins AI翻译
  作者：Wakim, Joseph G.; Spakowitz, Andrew J.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Euchromatin is an accessible phase of genetic material containing genes that encode proteins with increased expression levels. The structure of euchromatin in vitro has been described as a 30-nm fiber formed from ordered nucleosome arrays. However, recent advances in microscopy have revealed an in vivo euchromatin architecture that is much more disordered, characterized by variable-length linker DNA and sporadic nucleosome clusters. In this work, we develop a theoretical model to elucidate fac...
• Human parainfluenza virus 3 vaccine candidates attenuated by codon- pair deoptimization are immunogenic and protective in hamsters AI翻译
  作者：Afroz, Sharmin; Saul, Sirle; Dai, Jin; Surman, Sonja; Liu, Xueqiao; Park, Hong- Su; Le Nouen, Cyril; Lingemann, Matthias; Dahal, Bibha; Coleman, John Robert; Mueller, Steffen; Collins, Peter Leon; Buchholz, Ursula Johanna; Munir, Shirin
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
  摘要：Human parainfluenza virus type 3 (HPIV3) is a major pediatric respiratory pathogen lacking available vaccines or antiviral drugs. We generated live- attenuated HPIV3 vaccine candidates by codon- pair deoptimization (CPD). HPIV3 open reading frames (ORFs) encoding the nucleoprotein (N), phosphoprotein (P), matrix (M), fusion (F), hemagglutinin-neuraminidase (HN), and polymerase (L) were modified singly or in combination of N or L severely reduced growth in vitro and was not further evaluated. C...
• Collaborative imagination synchronizes representations of the future and fosters social connection in the present AI翻译
  作者：Fowler, Zoe; Palombo, Daniela J.; Madan, Christopher R.; O'Connor, Brendan Bo
  作者单位：State University of New York (SUNY) System; University of British Columbia; University of Nottingham
  摘要：From close friends to people on a first date, imagining a shared future appears fundamental to relationships. Yet, no previous research has conceptualized the act of imagination as a socially constructed process that affects how connected we feel to others. The present studies provide a framework for investigating imagination as a collaborative process in which individuals cocreate shared representations of hypothetical events-what we call collaborative imagination. Across two preregistered st...
• Cep57 regulates human centrosomes through multivalent interactions AI翻译
  作者：Yeh, Hung-Wei; Chen, Po-Pang; Yeh, Tzu-Chen; Lin, Shiou-Lan; Chen, Yue-Ting; Lin, Wan-Ping; Chen, Ting; Pang, Jia Meng; Lin, Kai-Ti; Wang, Lily Hui-Ching; Lin, Yu-Chun; Shih, Orion; Jeng, U-Ser; Hsia, Kuo-Chiang; Cheng, Hui-Chun
  作者单位：National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; National Synchrotron Radiation Research Center; National Tsing Hua University; Academia Sinica - Taiwan
  摘要：Human Cep57 is a coiled- coil scaffold at the pericentriolar matrix (PCM), controlling centriole duplication and centrosome maturation for faithful cell division. Genetic truncation mutations of Cep57 are associated with the mosaic- variegated aneuploidy (MVA) syndrome. During interphase, Cep57 forms a complex with Cep63 and Cep152, serving as regulators for centrosome maturation. However, the molecular interplay of Cep57 with these essential scaffolding proteins remains unclear. Here, we demo...
• A unified framework for perceived magnitude and discriminability of sensory stimuli AI翻译
  作者：Zhou, Jingyang; Duong, Lyndon R.; Simoncelli, Eero P.
  作者单位：Simons Foundation; Flatiron Institute; New York University; New York University
  摘要：The perception of sensory attributes is often quantified through measurements of sensitivity (the ability to detect small stimulus changes), as well as through direct judgments of appearance or intensity. Despite their ubiquity, the relationship between these two measurements remains controversial and unresolved. Here, we propose a framework in which they arise from different aspects of a common representation. Specifically, we assume that judgments of stimulus intensity (e.g., as measured thr...
• In situ visualizing reveals potential drive of lattice expansion on defective support toward efficient removal of nitrogen oxides AI翻译
  作者：Hao, Zhifei; Liu, Guoquan; Wang, Pengfei; Zhang, Weiyu; Sun, Wenming; Zheng, Lirong; Guo, Shaojun; Zhan, Sihui
  作者单位：Nankai University; Peking University; Capital Normal University; Chinese Academy of Sciences; Institute of High Energy Physics, CAS
  摘要：As a sustainable and promising approach of removing of nitrogen oxides (NOx), catalytic reduction of NOx with H-2 is highly desirable with a precise understanding to the structure-activity relationship of supported catalysts. In particular, the dynamic evolution of support at microscopic scale may play a critical role in heterogeneous catalysis, however, identifying the in situ structural change of support under working condition with atomic precision and revealing its role in catalysis is sti...
• Sensitivity of ocean circulation to warming during the Early Eocene greenhouse AI翻译
  作者：Turner, Sandra Kirtland; Ridgwell, Andy; Keller, Allison L.; Vahlenkamp, Maximilian; Aleksinski, Adam K.; Sexton, Philip F.; Penman, Donald E.; Hull, Pincelli M.; Norris, Richard D.; Canfield, Donald
  作者单位：University of California System; University of California Riverside; University of Bremen; Purdue University System; Purdue University; Open University - UK; Utah System of Higher Education; Utah State University; Yale University; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Multiple abrupt warming events (hyperthermals) punctuated the Early Eocene and were associated with deep- sea temperature increases of 2 to 4 degrees C, seafloor carbonate dissolution, and negative carbon isotope (delta 13C) excursions. Whether hyperthermals were associated with changes in the global ocean overturning circulation is important for understanding their driving mechanisms and feedbacks and for gaining insight into the circulation's sensitivity to climatic warming. Here, we present...
• Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance AI翻译
  作者：Wang, Na; Zhu, Biqing; Allnutt, Mary Alice; Grijalva, Rosalie M.; Zhao, Hongyu; Chandra, Sreeganga S.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Synapse maintenance is essential for generating functional circuitry, and decrement in this process is a hallmark of neurodegenerative disease. Yet, little is known about synapse maintenance in vivo. Cysteine string protein alpha (CSP alpha ), encoded by the Dnajc5 gene, is a synaptic vesicle chaperone that is necessary for synapse maintenance and linked to neurodegeneration. To investigate the transcriptional changes associated with synapse maintenance, we performed singlenucleus transcriptom...
• Coordinating plasmid partition with bacterial chromosome segregation AI翻译
  作者：Fommell, Barbara E.
  作者单位：University of Toronto
• MACSPI enables tissue- selective proteomic and interactomic analyses in multicellular organisms AI翻译
  作者：Huang, Siyue; Ran, Qiao; Li, Xiao-Meng; Bao, Xiucong; Zheng, Chaogu; Li, Xiang David
  作者单位：University of Hong Kong; University of Hong Kong; University of Hong Kong
  摘要：Multicellular organisms are composed of many tissue types that have distinct morphologies and functions, which are largely driven by specialized proteomes and interactomes. To define the proteome and interactome of a specific type of tissue in an intact animal, we developed a localized proteomics approach called Methionine Analog - based Cell - Specific Proteomics and Interactomics (MACSPI). This method uses the tissue - specific expression of an engineered methionyl - tRNA synthetase to label...