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作者：Chojkiewicz, Emilia; Paliwal, Umed; Abhyankar, Nikit; Baker, Casey; O'Connell, Ric; Callaway, Duncan; Phadke, Amol
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：As countries pursue decarbonization goals, the rapid expansion of transmission capacity for renewable energy (RE) integration poses a significant challenge due to hurdles such as permitting and cost allocation. However, we find that large- scale reconductoring with advanced composite- core conductors can cost- effectively double transmission capacity within existing right- of- way, with limited additional permitting. This strategy unlocks a high availability of increasingly economically viable...
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作者：Lee, Ting-Uei; Lu, Hongjia; Ma, Jiaming; San Ha, Ngoc; Gattas, Joseph M.; Xie, Yi Min
作者单位：Royal Melbourne Institute of Technology (RMIT); University of Queensland
摘要：Deployable tubular structures, designed for functional expansion, serve a wide range of applications, from flexible pipes to stiff structural elements. These structures, which transform from compact states, are crucial for creating adaptive solutions across engineering and scientific fields. A significant barrier to advancing their performance is balancing expandability with stiffness. Using compliant materials, these structures achieve more flexible transformations than those possible with ri...
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作者：Tchebotarev, Lieve; Herzel, Lydia
作者单位：Free University of Berlin
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作者：Yao, Ningning; Song, Zhe; Chen, Lang; Sun, Yuhai; Jiang, Boqiong; Li, Pengfei; Chen, Jinsheng; Yu, Shaocai
作者单位：Zhejiang Gongshang University; Zhejiang Gongshang University; Zhejiang University; Chinese Academy of Sciences; Shanghai Institute of Technical Physics, CAS; Chinese Academy of Sciences; Institute of Urban Environment, CAS
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作者：Feng, Xu; Yang, Chang; Huang, Yuanjian; Su, Dan; Wang, Chao; Wilson, Lori Lyn; Yin, Ling; Tang, Mengfan; Li, Siting; Chen, Zhen; Zhu, Dandan; Wang, Shimin; Zhang, Shengzhe; Zhang, Jie; Zhang, Huimin; Nie, Litong; Huang, Min; Park, Jae - Il; Hart, Traver; Jiang, Dadi; Jiang, Kuirong; Chen, Junjie
作者单位：Nanjing Medical University; Nanjing Medical University; Nanjing Medical University; University of Texas System; UTMD Anderson Cancer Center; Harbin Medical University; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
摘要：Immune evasion is not only critical for tumor initiation and progression, but also determines the efficacy of immunotherapies. Through iterative in vivo CRISPR screens with seven syngeneic tumor models, we identified core and context- dependent immune evasion pathways across cancer types. This valuable high- confidence dataset is available for the further understanding of tumor intrinsic immunomodulators, which may lead to the discovery of effective anticancer therapeutic targets. With a focus...
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作者：Wilhelm, Kiera B.; Vissa, Anand; Groves, Jay T.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Wisconsin System; University of Wisconsin Madison
摘要：Antibody- derived T- cell receptor (TCR) agonists are commonly used to activate T cells. While antibodies can trigger TCRs regardless of clonotype, they bypass native T cell signal integration mechanisms that rely on monovalent, membrane- associated, and relatively weakly binding ligand in the context of cellular adhesion. Commonly used antibodies and their derivatives bind much more strongly than native peptide major histocompatibility complex (pMHC) ligands bind their cognate TCRs. Because l...
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作者：Lu, Sen; Li, Xuechuan; Cheng, Yumeng; Zhou, Jia; Zhang, Guan
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作者：Baker, Rosanna P.; Liu, Amy Z.; Casadevall, Arturo
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
摘要：Cryptococcus neoformans has emerged as a frontrunner among deadly fungal pathogens and is particularly life- threatening for many HIV- infected individuals with compromised immunity. Multiple virulence factors contribute to the growth and survival of C. neoformans within the human host, the two most prominent of which are the polysaccharide capsule and melanin. As both of these features are associated with the cell wall, we were interested to explore possible cooperative or competitive interac...
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作者：Komarova, Natalia L.; Rignot, Chiara; Fleischman, Angela G.; Wodarz, Dominik
作者单位：University of California System; University of California San Diego; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California San Diego
摘要：A major next step in hematopoietic stem cell (HSC) biology is to enhance our quantitative understanding of cellular and evolutionary dynamics involved in undisturbed hematopoiesis. Mathematical models have been and continue to be key in this respect, and are most powerful when parameterized experimentally and containing sufficient biological complexity. In this paper, we use data from label propagation experiments in mice to parameterize a mathematical model of hematopoiesis that includes home...
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作者：Shuvaev, Sergey; Lachi, Divyansha; Koulakov, Alexei; Zador, Anthony
摘要：Animals are born with extensive innate behavioral capabilities, which arise from neural circuits encoded in the genome. However, the information capacity of the genome is orders of magnitude smaller than that needed to specify the connectivity of an arbitrary brain circuit, indicating that the rules encoding circuit formation must fit through a genomic bottleneck as they pass from one generation to the next. Here, we formulate the problem of innate behavioral capacity in the context of artific...
