Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Utilizing developmental dynamics for evolutionary prediction and control AI翻译
  作者：Milocco, Lisandro; Uller, Tobias
  作者单位：Lund University
  摘要：Understanding, predicting, and controlling the phenotypic consequences of genetic and environmental change is essential to many areas of fundamental and applied biology. In evolutionary biology, the generative process of development is a major source of organismal evolvability that constrains or facilitates adaptive change by shaping the distribution of phenotypic variation that selection can act upon. While the complex interactions between genetic and environmental factors during development ...
• Identification of a negative- strand RNA virus with natural plant and fungal hosts AI翻译
  作者：Dai, Ruoyin; Yang, Shian; Pang, Tianxing; Tian, Mengyuan; Wang, Hao; Zhang, Dong; Wu, Yunfeng; Kondo, Hideki; Andika, Ida Bagus; Kang, Zhensheng; Sun, Liying
  作者单位：Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Okayama University; Qingdao Agricultural University; Northwest A&F University - China
  摘要：The presence of viruses that spread to both plant and fungal populations in nature has posed intriguingly scientific question. We found a negativestrand RNA virus related to members of the family Phenuiviridae, named Valsa mali negativestrand RNA virus 1 (VmNSRV1), which induced strong hypovirulence and was prevalent in a population of the phytopathogenic fungus of apple Valsa canker (Valsa mali) infecting apple orchards in the Shaanxi Province of China. Intriguingly, VmNSRV1 encodes a protein...
• Rapid and automated design of two- component protein nanomaterials using ProteinMPNN AI翻译
  作者：de Haas, Robbert J.; Brunette, Natalie; Goodson, Alex; Dauparas, Justas; Yi, Sue Y.; Yang, Erin C.; Dowling, Quinton; Nguyen, Hannah; Kang, Alex; Bera, Asim K.; Sankaran, Banumathi; de Vries, Renko; Baker, David; King, Neil P.
  作者单位：Wageningen University & Research; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Howard Hughes Medical Institute
  摘要：The design of protein-protein interfaces using physics - based design methods such as Rosetta requires substantial computational resources and manual refinement by expert structural biologists. Deep learning methods promise to simplify protein-protein interface design and enable its application to a wide variety of problems by researchers from various scientific disciplines. Here, we test the ability of a deep learning method for protein sequence design, ProteinMPNN, to design two- component t...
• Tailoring the aluminum nanocrystal surface oxide for all- aluminum- based antenna- reactor plasmonic photocatalysts AI翻译
  作者：Bayles, Aaron; Fabiano, Catherine J.; Shi, Chuqiao; Yuan, Lin; Yuan, Yigao; Craft, Nolan; Jacobson, Christian R.; Dhindsa, Parmeet; Ogundare, Adebola; Camacho, Yelsin Mendez; Chen, Banghao; Robatjazi, Hossein; Han, Yimo; Strouse, Geoffrey F.; Nordlander, Peter; Everit, Henry O.; Halas, Naomi J.
  作者单位：Rice University; Rice University; State University System of Florida; Florida State University; Rice University; Rice University; Rice University; Rice University
  摘要：Aluminum nanocrystals (AlNCs) are of increasing interest as sustainable, earth- abundant nanoparticles for visible wavelength plasmonics and as versatile nanoantennas for energy- efficient plasmonic photocatalysis. Here, we show that annealing AlNCs under various gases and thermal conditions induces substantial, systematic changes in their surface oxide, modifying crystalline phase, surface morphology, density, and defect type and concentration. Tailoring the surface oxide properties enables A...
• Integrating chemistry, fluid flow, and mechanics to drive spontaneous formation of three- dimensional (3D) patterns in anchored microstructures AI翻译
  作者：Moradi, Moslem; Shklyaev, Oleg E.; Balazs, Anna C.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Enzymatic reactions in solution drive the convection of confined fluids throughout the enclosing chambers and thereby couple the processes of reaction and convection. In these systems, the energy released from the chemical reactions generates a force, which propels the fluids' spontaneous motion. Here, we use theoretical and computational modeling to determine how reaction-convection can be harnessed to tailor and control the dynamic behavior of soft matter immersed in solution. Our model syst...
• A pharynx- to- brain axis controls pharyngeal inflammation- induced anxiety AI翻译
  作者：Zhao, Wan; Zhang, Ke; Dong, Wan - Ying; Di Tang, Hao-; Sun, Jia - Qiang; Huang, Ji - Ye; Wan, Guang- Lun; Guan, Rui- Rui; Guo, Xiao- Tao; Cheng, Ping - Kai; Tao, Ran; Sun, Jing- Wu; Zhang, Zhi; Zhu, Xia
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Sichuan University; Anhui Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Anxiety is a remarkably common condition among patients with pharyngitis, but the relationship between these disorders has received little research attention, and the underlying neural mechanisms remain unknown. Here, we show that the densely innervated pharynx transmits signals induced by pharyngeal inflammation to glossopharyngeal and vagal sensory neurons of the nodose/jugular/petrosal (NJP) superganglia in mice. Specifically, the NJP superganglia project to norepinephrinergic neurons in th...
• Cellular and molecular organization of the Drosophila foregut AI翻译
  作者：Zhu, Haolong; Ludington, William B.; Spradling, Allan C.
  作者单位：Carnegie Institution for Science; Johns Hopkins University; Howard Hughes Medical Institute
  摘要：The animal foregut is the first tissue to encounter ingested food, bacteria, and viruses. We characterized the adult Drosophila foregut using transcriptomics to better understand how it triages consumed items for digestion or immune response and manages resources. Cell types were assigned and validated using GFP- tagged and Gal4 reporter lines. Foregut- associated neuroendocrine cells play a major integrative role by coordinating gut activity with nutrition, the microbiome, and circadian cycle...
• Incipient functional SARS-CoV-2 diversification identified through neural network haplotype maps AI翻译
  作者：Delgado, Soledad; Somovilla, Pilar; Ferrer-Orta, Cristina; Martinez-Gonzalez, Brenda; Vazquez-Monteagudo, Sergi; Munoz-Flores, Javier; Soria, Maria Eugenia; Garcia-Crespo, Carlos; de Avila, Ana Isabel; Duran-Pastor, Antoni; Gadea, Ignacio; Lopez-Galindez, Cecilio; Moran, Federico; Lorenzo-Redondo, Ramon; Verdaguer, Nuria; Perales, Celia; Domingo, Esteban
  作者单位：Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa (CBM); Autonomous University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Biologia Molecular de Barcelona (IBMB); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB); Autonomous University of Madrid; Instituto de Salud Carlos III; Centro Nacional de Microbiologia (CNM); Complutense University of Madrid; Northwestern University; Feinberg School of Medicine
  摘要：Since its introduction in the human population, SARS-CoV-2 has evolved into multiple clades, but the events in its intrahost diversification are not well understood. Here, we compare three- dimensional (3D) self- organized neural haplotype maps (SOMs) of SARS-CoV-2 from thirty individual nasopharyngeal diagnostic samples obtained within a 19- day interval in Madrid (Spain), at the time of transition between clades 19 and 20. SOMs have been trained with the haplotype repertoire present in the m...
• Genetic basis and trade-offs of cold acclimation AI翻译
  作者：Yoccoz, Nigel
  作者单位：UiT The Arctic University of Tromso
• Mucociliary transport in cystic fibrosis AI翻译
  作者：Cicuta, Pietro
  作者单位：University of Cambridge