Proceedings of the National Academy of Sciences of the United States of America

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• Individual transcription factors modulate both the micromovement of chromatin and its long- range structure AI翻译
  作者：Shaban, Haitham A.; Friman, Elias T.; Deluz, Cedric; Tollenaere, Armelle; Katanayeva, Natalya; Suter, David M.
  作者单位：Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Edinburgh; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Institute Experimental Cancer Research; Swiss School of Public Health (SSPH+); University of Geneva
  摘要：The control of eukaryotic gene expression is intimately connected to highly dynamic chromatin structures. Gene regulation relies on activator and repressor transcription factors (TFs) that induce local chromatin opening and closing. However, it is unclear how nucleuswide chromatin organization responds dynamically to the activity of specific TFs. Here, we examined how two TFs with opposite effects on local chromatin accessibility modulate chromatin dynamics nucleuswide. We combine high - resol...
• Enriching surface- ordered defects on WO3 for photocatalytic CO2-to-CH4 conversion by water AI翻译
  作者：Xue, Sikang; Wei, Changgeng; Shen, Min; Liang, Xiaocong; Wang, Jiali; Yang, Can; Xing, Wandong; Wang, Sibo; Lin, Wei; Yu, Zhiyang; Hou, Yidong; Yu, Jimmy C.; Wang, Xinchen
  作者单位：Fuzhou University; Fuzhou University; Chinese University of Hong Kong
  摘要：Defect engineering has been widely applied in semiconductors to improve photocatalytic properties by altering the surface structures. This study is about the transformation of inactive WO 3 nanosheets to a highly effective CO 2 - to - CH 4 conversion photocatalyst by introducing surface - ordered defects in abundance. The nonstoichiometric WO 3 - x samples were examined by using aberration - corrected electron microscopy. Results unveil abundant surface - ordered terminations derived from the ...
• Isotopes prove advanced, integral crop production, and stockbreeding strategies nourished Trypillia mega- populations (vol 120, e2312962120,2023) AI翻译
  作者：Schluetz, Frank; Hofmann, Robert; Dal Corso, Marta; Pashkevych, Galyna; Dreibrodt, Stefan; Shatilo, Mila; Terna, Andreea; Fuchs, Katharina; Filipovic, Dragana; Flohr, Pascal; Makarewicz, Cheryl A.; Terna, Stanislav; Videiko, Mykhailo; Rud, Vitalii; Mueller, Johannes; Kirleis, Wiebke
  作者单位：University of Kiel; University of Kiel; University of Padua; National Academy of Sciences Ukraine; University of Kiel; University of Kiel; Ministry of Education & Science of Ukraine; Borys Grinchenko Kyiv Metropolitan University; National Academy of Sciences Ukraine; Institute of Archaeology, National Academy of Sciences of Ukraine
  摘要：which published December 18, 2023; 10.1073/pnas.2312962120 (Proc. Natl. Acad. Sci. Stanislav ?erna should be added to the author list between Katharina Fuchs and forming research in an early stage of the study, and Pascal Flohr and Cheryl A. Makarewicz should be credited with contributing data analysis and interpretation in The authors also note that the author names Marta dal Corso and Andreea Terna should The corrected author line, affiliation line, and author contributions appear below. The...
• WAV E3 ubiquitin ligases mediate degradation of IAA32/34 in the TMK1-mediated auxin signaling pathway during apical hook development AI翻译
  作者：Wang, Jun-Li; Wang, Ming; Zhang, Li; Li, You-Xia; Li, Jing-Jing; Li, Yu-Yang; Pu, Zuo-Xian; Li, Dan-Yang; Liu, Xing-Nan; Guo, Wang; Di, Dong-Wei; Li, Xiao-Feng; Guo, Guang-Qin; Wu, Lei
  作者单位：Lanzhou University; Lanzhou University; Nanjing Agricultural University; Fujian Agriculture & Forestry University; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS
  摘要：Auxin regulates plant growth and development through downstream signaling pathways, including the best - known SCF TIR1/AFB - Aux/IAA - ARF pathway and several other less characterized noncanonical pathways. Recently, one SCF TIR1/AFB - independent noncanonical pathway, mediated by Transmembrane Kinase 1 (TMK1), was discovered through the analyses of its functions in Arabidopsis apical hook development. Asymmetric accumulation of auxin on the concave side of the apical hook triggers DAR1 - cat...
• Modern archaeological research and the importance of information management AI翻译
  作者：Anderson, David G.
  作者单位：University of Tennessee System; University of Tennessee Knoxville
• Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onsetdelaying genetic modification in Huntington's disease AI翻译
  作者：Kim, Kyung-Hee; Hong, Eun Pyo; Lee, Yukyeong; Mclean, Zachariah L.; Elezi, Emanuela; Lee, Ramee; Kwak, Seung; Mcallister, Branduff; Massey, Thomas H.; Lobanov, Sergey; Holmans, Peter; Orth, Michael; Ciosi, Marc; Monckton, Darren G.; Long, Jeffrey D.; Lucente, Diane; Wheeler, Vanessa C.; Macdonald, Marcy E.; Gusella, James F.; Lee, Jong- Min
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; CHDI Foundation, Inc.; Cardiff University; University of Glasgow; University of Iowa; University of Iowa; Harvard University; Harvard Medical School
  摘要：Many Mendelian disorders, such as Huntington's disease (HD) and spinocerebellar ataxias, arise from expansions of CAG trinucleotide repeats. Despite the clear genetic causes, additional genetic factors may influence the rate of those monogenic disorders. Notably, genome - wide association studies discovered somewhat expected modifiers, particularly mismatch repair genes involved in the CAG repeat instability, impacting age at onset of HD. Strikingly, FAN1 , previously unrelated to repeat insta...
• The MUC1-HIF-1α signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling AI翻译
  作者：Murthy, Divya; Attri, Kuldeep S.; Suresh, Voddu; Rajacharya, Girish H.; Valenzuela, Carlos A.; Thakur, Ravi; Zhao, Junzhang; Shukla, Surendra K.; V. Chaika, Nina; Labreck, Drew; V. Rao, Chinthalapally; Hollingsworth, Michael A.; Mehla, Kamiya; Singh, Pankaj K.
  作者单位：University of Nebraska System; University of Nebraska Medical Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Oklahoma System; University of Oklahoma Health Sciences Center
  摘要：Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the role of MUC1, a mucin protein overexpressed in pancreatic cancer, in regulating polyamine metabolism. Utilizing pancreatic cancer patient data, we noted a positive correlation between MUC1 expression and the expression of key polyamine metabolism pathway genes. Functional studies r...
• Mesoscale structure of the atmospheric boundary layer across a natural roughness transition AI翻译
  作者：Cooke, Justin; Jerolmack, Douglas; Park, George Ilhwan
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：The structure and intensity of turbulence in the atmospheric boundary layer (ABL) drive fluxes of sediment, contaminants, heat, moisture, and CO2 at the Earth's surface. Where ABL flows encounter changes in roughness-such as cities, wind farms, forest canopies, and landforms-a new mesoscopic flow scale is introduced: the internal boundary layer (IBL), which represents a near -bed region of transient flow adjustment that develops over kilometers. Measurement of this new mesoscopic scale lies ou...
• Isolated steady solutions of the 3D Euler equations AI翻译
  作者：Enciso, Alberto; Kepplinger, Willi; Peralta-Salas, Daniel
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencias Matematicas (ICMAT); University of Vienna
  摘要：We show that there exist closed three-dimensional Riemannian manifolds where the incompressible Euler equations exhibit smooth steady solutions that are isolated in the 1-topology. The proof of this fact combines ideas from dynamical systems, which appear naturally because these isolated states have strongly chaotic dynamics, with techniques from spectral geometry and contact topology, which can be effectively used to analyze the steady Euler equations on carefully chosen Riemannian manifolds....
• Force- induced tail- autotomy mitochondrial fission and biogenesis of matrixexcluded mitochondrial- derived vesicles for quality control AI翻译
  作者：Liu, Xiaoying; Xu, Linyu; Song, Yutong; Zhao, Zhihao; Li, Xinyu; Wong, Cheuk - Yiu; Chen, Rong; Feng, Jianxiong; Gou, Yitao; Qi, Yajing; Chow, Hei-Man; Yao, Shuhuai; Wang, Yi; Gao, Song; Liu, Xingguo; Duan, Liting
  作者单位：Chinese University of Hong Kong; Hong Kong University of Science & Technology; Sun Yat Sen University; State Key Lab Oncology South China; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Hong Kong University of Science & Technology; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Guangzhou Medical University; Chinese Academy of Sciences
  摘要：Mitochondria constantly fuse and divide for mitochondrial inheritance and functions. Here, we identified a distinct type of naturally occurring fission, tail- autotomy fission, wherein a tail - like thin tubule protrudes from the mitochondrial body and disconnects, resembling autotomy. Next, utilizing an optogenetic mitochondria- specific mechanostimulator, we revealed that mechanical tensile force drives tail- autotomy fission. This force- induced fission involves DRP1/MFF and endoplasmic ret...