Proceedings of the National Academy of Sciences of the United States of America

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• Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease AI翻译
  作者：Chakraborty, Anirban; Sreenivasmurthy, Sravan Gopalkrishnashetty; Miller, Wyatt; Huai, Weihan; Biswas, Tapan; Mandal, Santi Mohan; Bosca, Lisardo; Krishnan, Balaji; Ghosh, Gourisankar; Hazra, Tapas
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of California System; University of California San Diego; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Madrid
  摘要：Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding glutamine) repeat expansion in the coding region of the huntingtin (HTT) and ataxin-3 (ATXN3) proteins, respectively. We have earlier reported that the activity, but not the protein level, of an essential DNA repair enzyme, polynucleotide kinase 3'-phosphatase (PNKP), is severely abrogated in both HD and SCA3 resulting in accumu...
• Agricultural flood resistance enhanced after returning farmlands to lakes AI翻译
  作者：Liu, Ruoqi; Dong, Jinwei; Jiang, Luguang; Ge, Yong; Fan, Chang; Yang, Tong; Zhang, Geli
  作者单位：China Agricultural University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Jiangxi Normal University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：The Returning Farmland to Lakes (RFTL) project began in China following the catastrophic 1998 floods. It aims to recover flood storage capacity and mitigate flood risk to agriculture and people. This flood adaptation strategy divides the floodplain into three types of restoration polders with different flood control levels (double restoration polders, single restoration polders, and storage polders) and polders for intensive production and living (nonrestoration polders). During the substantia...
• Estimating future climate change impacts on human mortality and crop yields via air pollution AI翻译
  作者：Murray, Lee T.; Leibensperger, Eric M.; Mickley, Loretta J.; Tai, Amos P. K.
  作者单位：University of Rochester; University of Rochester; Ithaca College; Harvard University; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong
  摘要：Future climate change may bring local benefits or penalties to surface air pollution, resulting from changing temperature, precipitation, and transport patterns, as well as changes in climate-sensitive natural precursor emissions. Here, we estimate the climate penalties and benefits at the end of this century with regard to surface ozone and fine particulate matter (PM2.5; excluding dust and smoke) using a one-way offline coupling between a general circulation model and a global 3-D chemical-t...
• Ramping cells in the rodent medial prefrontal cortex encode time to past and future events via real Laplace transform AI翻译
  作者：Cao, Rui; Bright, Ian M.; Howard, Marc W.
  作者单位：Boston University
  摘要：In interval reproduction tasks, animals must remember the event starting the interval and anticipate the time of the planned response to terminate the interval. The interval reproduction task thus allows for studying both memory for the past and anticipation of the future. We analyzed previously published recordings from the rodent medial prefrontal cortex [J. Henke et al., eLife 10, e71612 (2021)] during an interval reproduction task and identified two cell groups by modeling their temporal r...
• Childhood PM2.5 exposure and upward mobility in the United States AI翻译
  作者：Lee, Sophie-An Kingsbury; Merlo, Luca; Dominici, Francesca
  作者单位：European University of Rome; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Although it is well documented that exposure to fine particulate matter (PM2.5) increases the risk of several adverse health outcomes, less is known about its relationship with economic opportunity. Previous studies have relied on regression modeling, which implied strict assumptions regarding confounding adjustments and did not explore geographical heterogeneity. We obtained data for 63,165 US census tracts (86% of all census tracts in the United States) on absolute upward mobility (AUM) defi...
• Three- dimensional chromatin mapping of sensory neurons reveals that promoter-enhancer looping is required for axonal regeneration AI翻译
  作者：Palmisano, Ilaria; Liu, Tong; Gao, Wei; Zhou, Luming; Merkenschlager, Matthias; Mueller, Franziska; Chadwick, Jessica; Rivalta, Rebecca Toscano; Kong, Guiping; King, James W. D.; Jibury, Ediem Al -; Yan, Yuyang; Carlino, Alessandro; Collison, Bryce; De Vitis, Eleonora; Gongala, Sree; De Virgiliis, Francesco; Wang, Zheng; Di Giovanni, Simone
  作者单位：Imperial College London; University System of Ohio; Ohio State University; University of Miami; Imperial College London
  摘要：The in vivo three- dimensional genomic architecture of adult mature neurons at homeostasis and after medically relevant perturbations such as axonal injury remains elusive. Here, we address this knowledge gap by mapping the three- dimensional chromatin architecture and gene expression program at homeostasis and after sciatic nerve injury in wild- type and cohesin- deficient mouse sensory dorsal root ganglia neurons via combinatorial Hi- C, promoter- capture Hi- C, CUT&Tag for H3K27ac and RNA-s...
• MiR-155-targeted IcosL controls tumor rejection (vol 121, e2408649121, 2024) AI翻译
  作者：Tili, Esmerina; Otsu, Hajime; Commisso, Teresa L.; Palamarchuk, Alexey; Balatti, Veronica; Michaille, Jean-Jacques; Nuovo, Gerard James; Croce, Carlo M.
• Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss AI翻译
  作者：Akiba, Ryutaro; Boniec, Shane Lind; Knecht, Sharm; Uyama, Hirofumi; Tu, Hung- Ya; Baba, Takayuki; Takahashi, Masayo; Mandai, Michiko; Wong, Rachel O.
  作者单位：University of Washington; University of Washington Seattle; RIKEN; Chiba University; University of Osaka
  摘要：The retinal fovea in human and nonhuman primates is essential for high acuity and color vision. Within the fovea lies specialized circuitry in which signals from a single cone photoreceptor are largely conveyed to one ON and one OFF type midget bipolar cell (MBC), which in turn connect to a single ON or OFF midget ganglion cell (MGC), respectively. Restoring foveal vision requires not only photoreceptor replacement but also appropriate reconnection with surviving ON and OFF MBCs and MGCs. Howe...
• The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease AI翻译
  作者：Jensen, Anne Mette G.; Raska, Jan; Fojtik, Petr; Monti, Giulia; Lunding, Melanie; Bartova, Simona; Pospisilova, Veronika; van der Lee, Sven J.; Van Dongen, Jasper; Bossaerts, Liene; Van Broeckhoven, Christine; Dols-Icardo, Oriol; Lleo, Alberto; Bellini, Sonia; Ghidoni, Roberta; Hulsman, Marc; Petsko, Gregory A.; Sleegers, Kristel; Bohaciakova, Dasa; Holstege, Henne; Andersen, Olav M.
  作者单位：Aarhus University; Masaryk University; St. Anne's University Hospital Brno (FNUSA); St. Anne's University Hospital Brno (FNUSA-ICRC); Vrije Universiteit Amsterdam; Flanders Institute for Biotechnology (VIB); University of Antwerp; Flanders Institute for Biotechnology (VIB); Autonomous University of Barcelona; CIBERNED; Autonomous University of Barcelona; IRCCS Fatebenefratelli; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA, have been accepted as causal of Alzheimer's disease (AD). However, most genetic variants observed in SORL1 are missense variants, for which it is complicated to determine the pathogenicity level because carriers come from pedigrees too small to be informative for penetrance estimations. Here, we describe three unrelated families in which the SORL1 coding missense variant rs772677709, that leads to a p.Y1816C ...
• Charting the future of high forest low deforestation jurisdictions AI翻译
  作者：Teo, Hoong Chen; Sarira, Tasya Vadya; Tan, Audrey R. P.; Cheng, Yanyan; Koh, Lian Pin
  作者单位：National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore
  摘要：High forest low deforestation jurisdictions (HFLDs) contain many of the world's last intact forests with historically low deforestation. Since carbon financing typically uses historical deforestation rates as baselines, HFLDs facing the prospect of future threats may receive insufficient incentives to be protected. We found that from 2002 to 2020, HFLDs (n = 310) experienced 44% higher deforestation rates than their historical baselines, and 60 HFLDs underwent periods of high deforestation (de...