Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Human behavior and disease dynamics AI翻译
  作者：Bergstrom, Carl T.; Hanage, William P.
  作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard T.H. Chan School of Public Health
• Perceived memory credibility: The role of details AI翻译
  作者：Nadel, Lynn; Simon, Katharine C.
  作者单位：University of Arizona; University of Arizona; University of California System; University of California Irvine
  摘要：The sharing of personal memories is a unique aspect of the human experience. Humans communicate to provide information, to influence, or even to amuse. How do we distinguish between credible and noncredible narratives? Forensic science has identified race, age, and detail quantity as influential. We do not know how the nature of narrated details impacts believability. We report two studies investigating how detail composition influences credibility ratings using definitions of details suggeste...
• Complement C3d enables cell- mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells AI翻译
  作者：Platt, Jeffrey L.; Zhao, Chong; Chicca, Jeffrey; Pianko, Matthew J.; Han, Joshua; The, Stephanie; Rao, Arvind; Keller, Evan T.; Barbosa, Mayara Garcia de Mattos; Naing, Lwar; Pasieka-Axenov, Tracy; Axenov, Lev; Schaefer, Simon; Farkash, Evan; Cascalho, Marilia
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Erlangen Nuremberg; University of Michigan System; University of Michigan
  摘要：Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell- mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a previously unknown function for intracellular C3d, we found that C3d engaged T cell responses against malignant PC in the bone marrow of mic...
• pERK transition-induced directional mode switching promotes epithelial tumor cell migration AI翻译
  作者：Yu, Huijing; Xiao, Guanli; Gu, Mingyao; Zhang, Liting; Xia, Ming; Mo, Shimin; Zhao, Yuying; Wei, Chaoliang
  作者单位：Shenzhen University; Shenzhen University; Shenzhen Longhua District Central Hospital; Guangzhou Medical University
  摘要：Increasing evidence suggests that tumor cells exhibit extreme plasticity in migration modes in order to adapt to microenvironments. However, the underlying mechanism for governing the migration mode switching is still unclear. Here, we revealed that epithelial tumor cells could develop a stable directional mode driven by hyperactivated ERK activity. This highly activated and dynamically changing ERK activity, called pERK transition, is crucial for inducing the switch from pauses state to direc...
• eLemur: A cellular-resolution 3D atlas of the mouse lemur brain AI翻译
  作者：Jeon, Hyungju; Kim, Jiwon; Kim, Jayoung; Choi, Yoon Kyoung; Ho, Chun Lum Andy; Pifferi, Fabien; Huber, Daniel; Feng, Linqing; Kim, Jinhyun
  作者单位：Korea Institute of Science & Technology (KIST); Korea University; University of Geneva; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); Sungkyunkwan University (SKKU); Korea Institute of Science & Technology (KIST)
  摘要：The gray mouse lemur ( Microcebus murinus), one of the smallest living primates, emerges as a promising model organism for neuroscience research. This is due to its genetic similarity to humans, its evolutionary position between rodents and humans, and its primate- like features encapsulated within a rodent- sized brain. Despite its potential, the absence of a comprehensive reference brain atlas impedes the progress of research endeavors in this species, particularly at the microscopic level. ...
• Ecosystem stability relies on diversity difference between trophic levels AI翻译
  作者：Liu, Yizhou; Hu, Jiliang; Gore, Jeff
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：The stability of ecological communities has a profound impact on humans, ranging from individual health influenced by the microbiome to ecosystem services provided by fisheries. A long- standing goal of ecology is the elucidation of the interplay between biodiversity and ecosystem stability, with some ecologists warning of instability due to loss of species diversity while others arguing that greater diversity will instead lead to instability. Here, by considering a minimal two- level ecosyste...
• Structure of yeast RAVE bound to a partial V1 complex AI翻译
  作者：Wang, Hanlin; Tarsio, Maureen; Kane, Patricia M.; Rubinstein, John L.
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; State University of New York (SUNY) System; SUNY Upstate Medical University; University of Toronto
  摘要：Vacuolar-type ATPases (V- ATPases) are membrane- embedded proton pumps that acidify intracellular compartments in almost all eukaryotic cells. Homologous with ATP synthases, these multisubunit enzymes consist of a soluble catalytic V1 subcomplex and a membrane- embedded proton- translocating VO subcomplex. The V1 and VO subcomplexes can undergo reversible dissociation to regulate proton pumping, with reassociation of V1 and VO requiring the protein complex known as RAVE (regulator of the ATPas...
• AgRP neurons mediate activity- dependent development of oxytocin connectivity and autonomic regulation AI翻译
  作者：Biddinger, Jessica E.; Elson, Amanda E. T.; Fathi, Payam A.; Sweet, Serena R.; Nishimori, Katsuhiko; Ayala, Julio E.; Simerly, Richard B.
  作者单位：Vanderbilt University; Children's Hospital Los Angeles; Fukushima Medical University
  摘要：During postnatal life, leptin specifies neuronal inputs to the paraventricular nucleus of the hypothalamus (PVH) and activates agouti- related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus. Activity- dependent developmental mechanisms impact refinement of sensory circuits, but whether leptin- mediated postnatal neuronal activity specifies hypothalamic neural projections is largely unexplored. Here, we used chemogenetics to manipulate the activity of AgRP neurons during a di...
• Multi- Component, Time- Course screening to develop combination cancer therapies based on synergistic toxicity AI翻译
  作者：Ceribelli, Michele; Tosto, Frances Anne; Zhang, Xiaohu; Melani, Christopher J.; Roschewski, Mark; Beck, Erin; Thomas, Carleen Klumpp -; Peer, Cody J.; Wilson, Kelli M.; Chen, Lu; Mcknight, Crystal; Michael, Sam; Itkin, Zina; Shinn, Paul; Figg Sr, William D.; Wilson, Wyndham H.; Staudt, Louis M.; Thomas, Craig J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Clinical trials in cancer are ideally built on a foundation of sound mechanistic rationale and well- validated drug activity in relevant disease models. The screening of approved and investigational drugs in cell- based phenotypic assays can provide evidence of drug activity, but alternative screening paradigms are needed to develop and optimize multidrug combination regimens. Here, we utilize in vitro screening outcomes across a panel of lymphoma cell lines to dissect the activity of four sma...
• Rigidity transition of a highly compressible granular medium AI翻译
  作者：Poincloux, Samuel; Takeuchi, Kazumasa A.
  作者单位：University of Tokyo; University of Tokyo; Aoyama Gakuin University
  摘要：A wide range of disordered materials, from biological to geological assemblies, feature discrete elements undergoing large shape changes. How significant geometrical variations at the microscopic scale affect the response of the assembly, in particular rigidity transitions, is an ongoing challenge in soft matter physics. However, the lack of a model granular-like experimental system featuring large and versatile particle deformability impedes advances. Here, we explore the oscillatory shear re...