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作者：Zhu, Fuwei; Ji, Luli; Dai, Kai; Deng, Shunshu; Wang, Jing; Liu, Changsheng
作者单位：East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology
摘要：The immunomodulatory function of mesenchymal stem cells (MSCs) is plastic and susceptible to resident microenvironment in vivo or inflammatory factors in vitro. We propose a unique method to enhance the immunoregulatory functions of mesenchymal stem cells (MSCs) through an artificially controllable in vivo inflammatory microenvironment generated by biomaterials loaded with BMP-2 that induce bone development. MSCs activated through this method effectively induce M1 macrophage polarization towar...
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作者：Sultan, Mubashir; Tump, Alan N.; Ehmann, Nina; Lorenz-Spreen, Philipp; Hertwig, Ralph; Gollwitzer, Anton; Kurvers, Ralf H. J. M.; Weber, Elke
作者单位：Max Planck Society; Humboldt University of Berlin; Technical University of Berlin; University of Konstanz; BI Norwegian Business School
摘要：Nearly five billion people use and receive news through social media and there is widespread concern about the negative consequences of misinformation on social media (e.g., election interference, vaccine hesitancy). Despite a burgeoning body of research on misinformation, it remains largely unclear who is susceptible to misinformation and why. To address this, we conducted a systematic individual participant data meta-analysis covering 256,337 unique choices made by 11,561 US-based participan...
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作者：Wang, Yijin; Thakur, Dhananjay; Duge, Emma; Murphy, Caroline; Girling, Ivan; Debeaubien, Nicolas A.; Chen, Jieyan; Nguyen, Benjamin H.; Gurav, Adishthi S.; Montell, Craig
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
摘要：Attraction and mating between male and female animals depend on effective communication between conspecifics. However, in mosquitoes, we have only a rudimentary understanding of the sensory cues and receptors critical for the communication that is essential for reproductive behavior. While it is known that male Aedes aegypti use sound to help them identify females, it is not unclear whether sound detection is absolutely required since other cues such as vision may also participate in mating be...
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作者：Bellina, Alessia; Malfatti, Matilde Clarissa; Salgado, Gilmar; Fleming, Aaron M.; Antoniali, Giulia; Othman, Zahraa; Gualandi, Nicola; La Manna, Sara; Marasco, Daniela; Dassi, Erik; Burrows, Cynthia J.; Tell, Gianluca
作者单位：University of Udine; Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Utah System of Higher Education; University of Utah; University of Naples Federico II; University of Trento
摘要：In the last decade, several novel functions of the mammalian Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APE1) have been discovered, going far beyond its canonical function as DNA repair enzyme and unveiling its potential roles in cancer development. Indeed, it was shown to be involved in DNA G- quadruplex biology and RNA metabolism, most importantly in the miRNA maturation pathway and the decay of oxidized or abasic miRNAs during oxidative stress conditions. In recent years, several noncan...
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作者：Kis, Noemi; Lueko, Balazs; Heredi, Judit; Mago, Adam; Erlinghagen, Bela; Ahmadi, Mahboubeh; Balind, Snezana Raus; Iras, Matyas; Ujfalussy, Balazs B.; Makara, Judit K.
作者单位：Semmelweis University; Okinawa Institute of Science & Technology Graduate University; University of California System; University of California Riverside
摘要：Active dendritic integrative mechanisms such as regenerative dendritic spikes enrich the information processing abilities of neurons and fundamentally contribute to behaviorally relevant computations. Dendritic Ca2+ spikes are generally thought to produce plateau- like dendritic depolarization and somatic complex spike burst (CSB) firing, which can initiate rapid changes in spatial coding properties of hippocampal pyramidal cells (PCs). However, here we reveal that a morpho- topographically di...
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作者：Mahdavi, Sara D.; Salmon, Gabriel L.; Daghlian, Patill; Garcia, Hernan G.; Phillips, Rob
作者单位：California Institute of Technology; California Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
摘要：Cells adapt to environments and tune gene expression by controlling the concentrations of proteins and their kinetics in regulatory networks. In both eukaryotes and prokaryotes, experiments and theory increasingly attest that these networks can and do consume biochemical energy. How does this dissipation enable cellular behaviors forbidden in equilibrium? This open question demands quantitative models that transcend thermodynamic equilibrium. Here, we study the control of simple, ubiquitous ge...
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作者：Newton, Matilda S.; Azadeh, Ashley L.; Morgenthaler, Andrew B.; Copley, Shelley D.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：The pathway for synthesis of proline in most forms of life produces a highly unstable intermediate, gamma- L- glutamyl 5- phosphate (GP). For nearly 70 y, channeling of this intermediate from the active site of glutamate 5- kinase to the active site of GP reductase has been believed to protect GP from cyclization to a dead- end product. However, the evidence presented in support of this idea is not conclusive. We show that changes in the structures of the kinase or reductase that should preclu...
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作者：Nikolic, Milos; Antonetti, Victoria; Liu, Feng; Muhaxheri, Gentian; Petkova, Mariela D.; Scheeler, Martin; Smith, Eric M.; Bialek, William; Gregor, Thomas
作者单位：Princeton University; Princeton University; City University of New York (CUNY) System; Lehman College (CUNY); Hebei University of Technology; Harvard University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
摘要：The expression of a few key genes determines the body plan of the fruit fly. We show that the spatial expression patterns for several of these genes scale precisely with embryo size. Discrete positional markers such as the peaks in striped patterns or the boundaries of expression domains have positions along the embryo's major axis proportional to embryo length, accurate to within 1%. Further, the information (in bits) that graded patterns of expression provide about a cell's position can be d...
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作者：Wang, Jia; Zhou, Weiqi; Pickett, Steward T. A.; Qian, Yuguo
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Cary Institute of Ecosystem Studies
摘要：Urban heat mitigation is a pressing concern for cities. Intense urban heat poses a threat to human health and urban sustainability. Tree planting is one of the most widely employed nature- based heat mitigation methods worldwide. Therefore, city policy makers require knowledge of how much temperature will be reduced by increasing urban tree canopy (UTC). Cooling efficiency (CE), which was been proposed to quantify the magnitude of temperature reduction associated with a 1% increase in UTC, has...
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作者：Chala, Desalegn; Endresen, Dag; Demissew, Sebsebe; Slaughter, Laura A.; Johnsen, Einar Broch; Stenseth, Nils Chr.
作者单位：University of Oslo; Addis Ababa University; University of Oslo; University of Oslo; University of Oslo; Addis Ababa University
