Proceedings of the National Academy of Sciences of the United States of America

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• A high- light therapy restores the circadian clock and corrects the pathological syndrome generated in restricted-fed mice AI翻译
  作者：Damara, Manohar; Misra, Nisha; Chambon, Pierre
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：Time- restricted feeding (RF) is known to shift the phasing of gene expression in most primary metabolic tissues, whereas a time misalignment between the suprachiasmatic nucleus circadian clock (SCNCC) and its peripheral CCs (PCC's) is known to induce various pathophysiological conditions, including a metabolic syndrome. We now report that a unique light therapy, involving different light intensities (T ZT0- ZT12150-TZT0- ZT12 700lx, T ZT0- ZT1275-TZT0- ZT12150 lx, and T ZT0- ZT12350-TZT0- ZT1...
• Local volume changes in deformed elastomers with mobile chains AI翻译
  作者：Hartquist, Chase; Wang, Shu; Zhao, Xuanhe
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Private management of African protected areas improves wildlife and tourism outcomes but with security concerns in conflict regions AI翻译
  作者：Denny, Sean; Englander, Gabriel; Hunnicutt, Patrick
  作者单位：University of California System; University of California Santa Barbara; The World Bank; Chapman University System; Chapman University; University of Oregon
  摘要：Protected areas can conserve wildlife and benefit people when managed effectively. African governments increasingly delegate the management of protected areas to private, nongovernmental organizations, hoping that private organizations' significant resources and technical capacities actualize protected areas' potential. Does private sector management improve outcomes compared to a counterfactual of government management? We leverage the transfer of management authority from governments to Afri...
• The Black Lives Matter movement mitigates bias against racial minority actors AI翻译
  作者：Lin, Yu- Wei; Yang, Shiyu; Han, Wencui; Lu, Jackson G.
  作者单位：Santa Clara University; California State University System; San Francisco State University; State University of New York (SUNY) System; Stony Brook University; Massachusetts Institute of Technology (MIT)
  摘要：Watching movies is among the most popular entertainment and cultural activities. How do viewers react when a movie sequel increases racial minority actors in the main cast (minority increase)? On the one hand, such sequels may receive better evaluations if viewers appreciate racially inclusive casting for its novel elements (the value- in-- diversity perspective) and moral appeal (the fairness perspective on diversity). On the other hand, discrimination research suggests that if viewers harbor...
• Relative decline in density of Northern Hemisphere tree species in warm and arid regions of their climate niches AI翻译
  作者：Astigarraga, Julen; Esquivel-Muelbert, Adriane; Ruiz-Benito, Paloma; Rodriguez-Sanchez, Francisco; Zavala, Miguel A.; Vila-Cabrera, Albert; Schelhaas, Mart-Jan; Kunstler, Georges; Woodall, Christopher W.; Cienciala, Emil; Dahlgren, Jonas; Govaere, Leen; Koenig, Louis A.; Lehtonen, Aleksi; Talarczyk, Andrzej; Liu, Daijun; Pugh, Thomas A. M.
  作者单位：Universidad de Alcala; University of Birmingham; University of Birmingham; Universidad de Alcala; University of Sevilla; Universidad de Alcala; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Wageningen University & Research; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); INRAE; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences; Swedish University of Agricultural Sciences; Swiss Federal Institutes of Technology Domain; ETH Zurich; Natural Resources Institute Finland (Luke); University of Vienna; Lund University
  摘要：Although climate change is expected to drive tree species toward colder and wetter regions of their distribution, broadscale empirical evidence is lacking. One possibility is that past and present human activities in forests obscure or alter the effects of climate. Here, using data from more than two million monitored trees from 73 widely distributed species, we quantify changes in tree species density within their climatic niches across Northern Hemisphere forests. We observe a reduction in m...
• Identifying changes in viral fitness using population genetic structure AI翻译
  作者：Petros, Brittany A.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
• Reply to van der Heijden and Starostin: On the persistent helicity of fluctuating ribbons AI翻译
  作者：Yong, Ee Hou; Dary, Farisan; Giomi, Luca; Mahadevan, L.
  作者单位：Nanyang Technological University; Leiden University - Excl LUMC; Leiden University; Harvard University; Harvard University; Harvard University
• Hydrogel morphogenesis induced by force- controlled growth AI翻译
  作者：Wang, Zhi Jian; Lin, Ji; Nakajima, Tasuku; Gong, Jian Ping
  作者单位：Hokkaido University; Hokkaido University; Ningbo University; Hokkaido University
  摘要：Morphogenesis is one of the most marvelous natural phenomena. The morphological characteristics of biological organs develop through growth, which is often triggered by mechanical force. In this study, we propose a bioinspired strategy for hydrogel morphogenesis through force - controlled chemical reaction and growth under isothermal conditions. We adopted a double network (DN) hydrogel with sacrificial bonds. Applying mechanical force to the gel caused deformation and sacrificial bond rupture...
• Incomplete- penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration (vol 121, e2318413121, 2024) AI翻译
  作者：Lee, Soah; Roest, Alison S. Vander; Blair, Cheavar A.; Kao, Kerry; Bremner, Samantha B.; Childers, Matthew C.; Pathak, Divya; Heinrich, Paul; Lee, Daniel; Chirikian, Orlando; Mohran, Saffie E.; Roberts, Brock; Smith, Jacqueline E.; Jahng, James W.; Paik, David T.; Wu, Joseph C.; Gunawardane, Ruwanthi N.; Ruppel, Kathleen M.; Mack, David L.; Pruitt, Beth L.; Regnier, Michael; Wu, Sean M.; Spudich, James A.; Bernstein, Daniel
• Ultrafast terahertz Stark spectroscopy reveals the excited-state dipole moments of retinal in bacteriorhodopsin AI翻译
  作者：Zhang, Jia; Singh, Poonam; Engel, Dieter; Fingerhut, Benjamin P.; Broser, Matthias; Hegemann, Peter; Elsaesser, Thomas
  作者单位：Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; University of Munich; University of Munich; Humboldt University of Berlin
  摘要：The photoinduced all -trans to 13 -cis isomerization of the retinal Schiff base represents the ultrafast first step in the reaction cycle of bacteriorhodopsin (BR). Extensive experimental and theoretical work has addressed excited -state dynamics and isomerization via a conical intersection with the ground state. In conflicting molecular pictures, the excited state potential energy surface has been modeled as a pure S 1 state that intersects with the ground state, or in a 3 -state picture invo...