Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Metabolomic insights into pathogenesis and therapeutic potential in adult acute lymphoblastic leukemia (vol 122, e2423169122, 2025) AI翻译
  作者：Wang, Jun-Yu; Gui, Tuan-Tuan; Jiao, Bo; Liu, Xuan; Ma, Xiao-Lin; Wang, Cheng; Qiao, Jing; Liu, Wei-Yang; Peng, Li-Jun; Ren, Jia-Yi; Zhu, Yong-Mei; Weng, Xiang-Qin; Wang, Chao; Zhang, Qian-Qian; Song, Gao-Xian; Dai, Yu-Ting; Wang, Zhen-Yi; Lv, Gang; Gao, Chen-Xu; Qiao, Niu; Zhang, Ming; Tan, Yun; Liu, Yuan-Fang; Wang, Sheng-Yue; Hou, Jian; Jing, Duo-Hui; Lyu, An-Kang; Mi, Jian-Qing; Chen, Zhu; Chen, Wen-Lian; Yin, Tong; Fang, Hai; Wang, Jin; Chen, Sai-Juan
• Belief in belief: Even atheists in secular countries show intuitive preferences favoring religious belief AI翻译
  作者：Gervais, Will M.; McKay, Ryan T.; Brown-Iannuzzi, Jazmin L.; Ross, Robert M.; Pennycook, Gordon; Jong, Jonathan; Lanman, Jonathan A.
  作者单位：Brunel University; University of London; Royal Holloway University London; University of Virginia; Macquarie University; Cornell University; Coventry University; Queens University Belfast
  摘要：We find evidence of belief in belief-intuitive preferences for religious belief over atheism, even among atheist participants-across eight comparatively secular countries. Religion is a cross-cultural human universal, yet explicit markers of religiosity have rapidly waned in large parts of the world in recent decades. We explored whether intuitive religious influence lingers, even among nonbelievers in largely secular societies. We adapted a classic experimental philosophy task to test for thi...
• The PBAP chromatin remodeling complex mediates summer diapause via H3K4me3-driven juvenile hormone regulation in Colaphellus bowringi AI翻译
  作者：Tian, Zhong; Wang, Kou; Guo, Shuang; Li, Jia - Xu; King-Jones, Kirst; Zhu, Fen; Liu, Wen; Wang, Xiao-Ping
  作者单位：Huazhong Agricultural University; Chengdu University of Traditional Chinese Medicine; University of Alberta
  摘要：Diapause, a developmental arrest mechanism, helps animals to survive seasonal changes via endocrine regulation. While obligate diapause is genetically programmed, facultative diapause is typically triggered by environmental cues such as photoperiod. In insects, this often leads to reproductive diapause characterized by reduced juvenile hormone (JH) signaling, resulting in ovarian arrest and lipid accumulation. However, the molecular link between photoperiod and hormonal control remains poorly ...
• Active matter as the underpinning agency for extraordinary sensitivity of biological membranes to electric fields AI翻译
  作者：Mathew, Anand; Kulkarni, Yashashree
  作者单位：University of Houston System; University of Houston
  摘要：Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as the minimum threshold for detection of electrical signals by cells. However, there is compelling experimental evidence that the minimum electric field sensed by certain cells and organisms is many orders of magnitude weaker than the thermal electrical noise limit estimated purely under equilibrium considerations...
• A solvable model for strongly interacting nonequilibrium excitons AI翻译
  作者：Song, Zhenhao; Cookmeyer, Tessa; Balents, Leon
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Canadian Institute for Advanced Research (CIFAR)
  摘要：We study the driven-dissipative Bose-Hubbard model with an all-to-all hopping term in the system Hamiltonian, while subject to incoherent pumping and decay from the environment. This system is naturally probed in several recent experiments on excitons in WS2/WSe2 moir & eacute; systems, as well as quantum simulators. By positing a particular form of coupling to the environment, we derive the Lindblad jump operators and show that, in certain limits, the system admits a closed-form expression fo...
• Identifying the interactions conferring functional mechanical rigidity on RNase-resistant RNA from Zika virus AI翻译
  作者：Zhaguparov, Daniiar; Zhao, Meng; Sekar, Rohith Vedhthaanth; Woodside, Michael T.
  作者单位：University of Alberta; University of Alberta; University of Alberta; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
  摘要：Some viruses counter host-cell efforts to digest invading viral RNA by using special structures resistant to host RNases, known as exoribonuclease-resistant RNAs (xrRNAs). xrRNAs typically form an unusual fold with the 5 '-end threaded through a ring consisting of a multihelix junction closed by a pseudoknot. By using single-molecule force spectroscopy (SMFS), we previously showed that a Zika virus xrRNA is extremely rigid mechanically, withstanding very high forces, and that this mechanical r...
• Unveiling the cold reality of metamorphic proteins AI翻译
  作者：LiWang, Andy; Orban, John
  作者单位：University of California System; University of California Merced; University of California System; University of California Merced; University System of Maryland; Universities at Shady Grove; University of Maryland Baltimore; University System of Maryland; University of Maryland College Park
  摘要：Metamorphic proteins switch reversibly between two differently folded states under a variety of environmental conditions. Their identification and prediction are gaining attention, but the fundamental physicochemical basis for fold switching remains poorly understood. In this Perspective article, we address this problem by surveying the landscape of well-characterized metamorphic proteins and noting that a significant fraction of them display temperature sensitivity. We then make the case that...
• The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells AI翻译
  作者：Jin, Jiacheng; Zhang, Ruohan; Li, Jianying; Gao, Fengxia; Liao, Zhiwei; Yu, Yanbao; Wang, Yi; Bucci, Donna; Xiao, Min; Ma, Ruilin; Ma, Qin; Gao, Shuaixin; Lio, Jerry; Novais, Fernanda; Huang, Stanley Ching- Cheng; Zhu, Jiangjiang; Ghoneim, Hazem; Wen, Haitao; Li, Zihai; Sun, Nuo; Xin, Gang
  作者单位：University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University of Delaware; New York University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Optimal activation of CD8+ T cells is crucial for immunity-mediated destruction of cancer, requiring a substantial amount of proteins involved in metabolism, proliferation, and effector function. Despite extensive studies emphasizing the role of transcriptional regulation in this process, paired transcriptomic and proteomic analyses reveal that the RNA profile is poorly correlated with protein levels. This discrepancy underscores the importance of post-translational modifications (PTMs) in con...
• Structural basis of SARS-CoV-2 polymerase inhibition by nonnucleoside inhibitor HeE1-2Tyr AI翻译
  作者：Kabinger, Florian; Doze, Valerie; Schmitzova, Jana; Lidschreiber, Michael; Dienemann, Christian; Cramer, Patrick
  摘要：Targeting the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 with small molecules is a promising therapeutic strategy against COVID-19, but potent and safe inhibitors are lacking. HeE1-2Tyr, a nonnucleoside inhibitor of Dengue virus RdRp, was also shown to inhibit SARS-CoV-2 RdRp in vitro and to have antiviral activity in cells, but the underlying mechanism remains unclear. Here, we elucidate the molecular mechanism of HeE1-2Tyr-mediated SARS-CoV-2 RdRp inhibition. Biochemical assays confir...
• Characterizing sliding and rolling contacts between single particles AI翻译
  作者：Scherrer, Simon; Ramakrishna, Shivaprakash N.; Niggel, Vincent; Hsu, Chiao-Peng; Style, Robert W.; Spencer, Nicholas D.; Isa, Lucio
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Technical University of Munich
  摘要：Contacts between particles in dense, sheared suspensions are believed to underpin much of their rheology. Roughness and adhesion are known to constrain the relative motion of particles, and thus globally affect the shear response, but an experimental description of how they microscopically influence the transmission of forces and relative displacements within contacts is lacking. Here, we show that an innovative colloidal-probe atomic force microscopy technique allows the simultaneous measurem...