Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Metabolomics navigates natural variation in pathogen- induced secondary metabolism across soybean cultivar populations AI翻译
  作者：Tian, Mengjun; Sun, Yaru; Zhang, Guodong; Xu, Yufei; Zhu, Jiang; Huang, Wenwen; Wang, Yizhan; Zhang, Bingcui; Li, Zhiyuan; Lin, Shaoyan; Zhang, Fang; Ma, Zhenchuan; Gan, Xiangchao; Tan, Junjie; Chen, Yu; Li, Suhua; Gai, Junyi; Xing, Guangnan; Wang, Ming; Wang, Yuanchao
  作者单位：Nanjing Agricultural University; Nanjing Agricultural University; Chinese Academy of Sciences; Nanjing Agricultural University; Nanjing Agricultural University; Nanjing Agricultural University; Nanjing Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS
  摘要：Phytophthora sojae- induced root rot poses a major threat to soybean production. While the molecular mechanisms underlying soybean-P. sojae interactions have been extensively studied, their biochemical basis remains largely unexplored. Previous research has identified key metabolic modules involved in pathogen defense, but structural diversity has largely been constrained by studies on single soybean accessions. Here, we broadened the chemical search space to a diverse soybean germplasm collec...
• Increased microbial carbon use efficiency upon abrupt permafrost thaw AI翻译
  作者：Qin, Shuqi; Wang, Guanqin; Zhang, Dianye; Yang, Yuanhe
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Soil carbon (C) dynamics upon permafrost thaw represents a major uncertainty in climate projections. Both soil C loss and formation in permafrost regions are mediated by microorganisms, and the balance of these two processes could be characterized by a synthetic metric termed microbial carbon use efficiency (CUE, defined as the ratio of C used for growth over C uptake). However, how microbial CUE responds to permafrost thaw remains unclear due to the lack of direct experimental evidence. Here,...
• Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse AI翻译
  作者：Hoffmann, Celine; Filali, Liza; Wurzer, Hannah; Fernandes, Diogo Pereira; Mgrditchian, Takouhie; Huang, Wanxin; Moreau, Flora; Krecke, Max; Thomas, Clement
  作者单位：Luxembourg Institute of Health; Luxembourg Institute of Health; University of Luxembourg; Eberhard Karls University of Tubingen
  摘要：Natural killer (NK) cells engage target cells via the immunological synapse (IS), where inhibitory and activating signals determine whether NK cell cytotoxicity is suppressed or activated. We previously reported that cancer cells can rapidly remodel their actin cytoskeleton upon NK cell engagement, leading to F-actin accumulation at the synapse. Here, we show that this process inhibits NK cell activation as indicated by impaired MTOC and lytic granule polarization. Exploring the underlying mec...
• Absence of phonon softening across a charge density wave transition due to quantum fluctuations AI翻译
  作者：Chen, Yubi; Kongruengkit, Terawit; Salinas, Andrea Capa; Yang, Runqing; Quan, Yujie; Zhang, Fanghao; Pokharel, Ganesh; Kautzsch, Linus; Wilson, Stephen D.; Mu, Sai; Harter, John W.; Liao, Bolin
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University System of Georgia; University of West Georgia; University of South Carolina System; University of South Carolina Columbia
  摘要：Kagome metals have emerged as a frontier in condensed matter physics due to their potential to host exotic quantum states. Among these, CsV3Sb5 has attracted significant attention for the unusual coexistence of charge density wave (CDW) order and unconventional superconductivity, presenting an ideal system for exploring the emergent phenomena from the interplay of phonons, electronic fluctuations, and topological effects. The nature of CDW formation in CsV3Sb5 is unconventional and has sparked...
• Semantic change in adults is not primarily a generational phenomenon AI翻译
  作者：Kamath, Gaurav; Yang, Michelle; Reddy, Siva; Sonderegger, Morgan; Card, Dallas
  作者单位：McGill University; Mila Quebec Artificial Intelligence Institute; McGill University; University of Michigan System; University of Michigan
  摘要：A central question in the study of language change is whether or not such change is generational. If a language changes over time generation-by-generation, the process looks as follows: New generations of speakers introduce innovations, while older speakers conserve their usage patterns, and the language changes as new generations replace older ones. At the opposite extreme, language change could be a zeitgeist phenomenon, in which changes are universally adopted by speakers simultaneously, re...
• Generation of actionable, cancer-specific neoantigens from KRAS(G12C) with adagrasib AI翻译
  作者：Maso, Lorenzo; Rajak, Epsa; Hattori, Takamitsu; Hu, Zhengshan; Koide, Akiko; Neel, Benjamin G.; Koide, Shohei
  作者单位：New York University; New York University; New York University
  摘要：Effective immune therapy against cancer ideally should target a cancer-specific antigen, an antigen that is present exclusively in cancer cells. However, there is a paucity of cancer-specific antigens that are endogenously produced. HapImmuneTM technology utilizes covalent inhibitors directed to an intracellular cancer driver to create cancer-specific neoantigens in the form of drug-peptide conjugates presented by class I MHC molecules. Our previous study with sotorasib, an FDA-approved covale...
• Fossil samples archive functional diversity in marine ecosystems: An empirical test from a present-day coastal environment AI翻译
  作者：Tyler, Carrie L.; Kowalewski, Micha
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; State University System of Florida; University of Florida
  摘要：The fossil record of functional diversity is increasingly used to study ecosystem evolution, extinction recovery, and factors affecting long-term trends in biodiversity. In addition, the youngest fossil record (late Quaternary) can provide insights into the natural range of functional variability of present-day ecosystems, providing a historical framework for conservation and restoration. However, the reliability of common functional diversity measures derived from fossils is uncertain. If fos...
• Bivalent interaction through an intrinsically disordered linker promotes transcription activation complex assembly in Notch signaling AI翻译
  作者：Cook, Cyril; Ramsey, Kristen M.; Barrick, Doug
  作者单位：Johns Hopkins University; University of Connecticut
  摘要：The Notch signaling pathway regulates cellular differentiation by activating transcription through an unusual heterotrimeric complex comprising the Notch receptor's intracellular domain (NICD), the DNA-binding protein CSL, and the coactivator MAML. NICD has two binding sites for CSL, a short motif in the RAM region and an ankyrin domain (ANK), connected by an intrinsically disordered linker and which form a bivalent ternary complex with CSL and MAML. Although bivalency is required for maximal ...
• Synergies between speciation and conservation science yield novel insights for mitigating the biodiversity crisis of the Anthropocene AI翻译
  作者：Wang, Silu; Yoder, Anne D.
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; Duke University
• Dynamic neuroplasticity of language networks: The intersection of bilingualism and epilepsy AI翻译
  作者：Stasenko, Alena; Kaestner, Erik; Schadler, Adam J.; Reyes, Anny; Urbanic, Clare; Helm, Jonathan L.; Saldana, Daniel; Carollo-Duprey, Giselle; Polczynska, Monika; Benjamin, Christopher; Sepeta, Leigh N.; Gollan, Tamar H.; Cavanagh, Lucia; McDonald, Carrie R.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Cleveland Clinic Foundation; California State University System; San Diego State University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; California Lutheran University; University of California System; University of California Los Angeles; University of British Columbia; Children's National Health System; University of California System; University of California San Diego
  摘要：Are bilingual language networks flexible enough to dynamically adapt to neurological insult? We examined language lateralization in 24 bilingual and 46 monolingual adults with temporal lobe epilepsy using functional MRI. In a group of primarily early sequential bilingual patients, the first acquired language (L1) showed more bilateral lateralization than in monolingual patients, with no effect of seizure onset laterality. In contrast, the second- acquired language (L2) was more bilateral in th...