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作者：Morriss, Matthew C.; Mitchell, Nate A.; Yanites, Brian J.; Staisch, Lydia M.; Korup, Oliver
作者单位：University of Oregon; Indiana University System; Indiana University Bloomington; United States Department of the Interior; United States Geological Survey; University of Potsdam; University of Potsdam
摘要：We explore how and when Hells Canyon, North America's deepest river gorge (similar to 2,400 m deep), formed, addressing these fundamental questions first posed by W. Lindgren [The Gold Belt of the Blue Mountains of Oregon (1901)]. Existing hypotheses about the canyon's formation and timing of incision remain speculative due to a lack of direct constraints and geomorphic analysis in the canyon. Herein, we combine cosmogenic nuclide dating of cave-bound river deposits, river profile analysis, an...
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作者：Alam, Raihan; Rai, Tage S.
作者单位：University of California System; University of California San Diego
摘要：Institutional legitimacy is essential for democracies, yet public trust and confidence in the United States Congress are at an all-time low. A significant predictor of attitudes toward Congress is perceptions of corruption, with perceptions of corruption in government linked to less legitimacy. This study tests whether knowledge of Congressional stock trading affects legitimacy and compliance with Congressional authority. In a preregistered experiment with US citizens (n = 506), participants w...
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作者：Chen, Zhaoyang; Tian, Li; Ge, Jin; Wang, Shiyu; Chen, Ting; Duan, Yuange; Song, Fan; Cai, Wanzhi; Wang, Zhengwei; Li, Hu
作者单位：China Agricultural University; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS
摘要：Tool use is widely reported across a broad range of the animal kingdom, yet comprehensive empirical tests of its function and evolutionary drivers remain scarce, predominantly focused on a few relatively intelligent vertebrate lineages. In this study, we provide a comprehensive examination of tool use behavior in the assassin bug Pahabengkakia piliceps, a specialist predator of stingless bees that exploits resin droplet from bee nest entrance to facilitate hunting. Field behavioral experiments...
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作者：Gupta, Shruti; Arnab, Sreejita; Nguyen, Kayla L.; Reed, Marisa; Fathi, Payam; Tammen, Kelly; Turner, Emma; Jones, Erin; Fischer, Roman; Mendelowitz, David; Bethea, John R.
作者单位：George Washington University; University of Pennsylvania; University of Stuttgart; George Washington University
摘要：Tumor necrosis factor receptor 2 (TNFR2) activation is a promising-therapeutic strategy for autoimmune disorders such as multiple sclerosis (MS) and chronic neuropathic pain (CNP). This study aimed to identify mechanisms governing the sex-specific efficacy of TNFR2 activation on abrogating pain and motor disease severity in mice experiencing experimental autoimmune encephalomyelitis (EAE), a rodent model of MS. We find that the XX sex-chromosome complement is indispensable for TNFR2-mediated a...
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作者：McArthur, Hannah C. W.; Bajur, Anna T.; Iliopoulou, Maro; Spillane, Katelyn M.
作者单位：University of London; King's College London; University of London; King's College London; Imperial College London
摘要：B cells discriminate antigens in immune synapses by capturing them from antigen-presenting cells (APCs). This discrimination relies on the application of mechanical force to B cell receptor (BCR)-antigen bonds, allowing B cells to selectively disrupt low-affinity interactions while internalizing high-affinity antigens. Using DNA-based tension sensors combined with high-resolution imaging, we demonstrate that the magnitude, location, and timing of forces within the immune synapse are influenced...
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作者：Kuhrts, Lucas; Shaked, Hadar; Sklar, Johanna; Prudnikov, Elena; Prevost, Sylvain; Manna, Gouranga; Sztucki, Michael; Katsman, Alexander; Pokroy, Boaz
作者单位：Technion Israel Institute of Technology; Institut Laue-Langevin (ILL); European Synchrotron Radiation Facility (ESRF)
摘要：Crystallization by amorphous calcium carbonate (ACC) particle attachment (CPA) is a prevalent biomineralization mechanism among calcifying organisms. A narrow, controlled size distribution of ACC nanoparticles is essential for macroscopic crystal formation via CPA. Using in situ synchrotron small-angle X-ray scattering, we demonstrate that synthetic magnesium-stabilized ACC (Mg-ACC) nanoparticles form with an exceptionally narrow size distribution near the spinodal line during liquid-liquid ph...
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作者：Dura, Tina; Chilton, William; Small, David; Garner, Andra J.; Hawkes, Andrea; Melgar, Diego; Engelhart, Simon E.; Staisch, Lydia M.; Witter, Robert C.; Nelson, Alan R.; Kelsey, Harvey M.; Allan, Jonathan C.; Bruce, David; Depaolis, Jessica; Priddy, Michael; Briggs, Richard W.; Weiss, Robert; La Selle, Seanpaul; Willis, Michael; Horton, Benjamin P.
作者单位：Virginia Polytechnic Institute & State University; University of Oregon; Rowan University; University of North Carolina; University of North Carolina Wilmington; Durham University; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; California State University System; California State Polytechnic University Pomona; United States Department of the Interior; United States Geological Survey; City University of Hong Kong; Nanyang Technological University; Nanyang Technological University
摘要：Climate-driven sea-level rise is increasing the frequency of coastal flooding worldwide, exacerbated locally by factors like land subsidence from groundwater and resource extraction. However, a process rarely considered in future sea-level rise scenarios is sudden (over minutes) land subsidence associated with great (>M8) earthquakes, which can exceed 1 m. Along the Washington, Oregon, and northern California coasts, the next great Cascadia subduction zone earthquake could cause up to 2 m of s...
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作者：Martin, Mariano; Bolognesi, Benedetta
作者单位：Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona
摘要：Stop-loss mutations cause over twenty different diseases. The effects of stop-loss mutations can have multiple consequences that are, however, hard to predict. Stop-loss in ITM2B/BRI2 results in C-terminal extension of the encoded protein and, upon furin cleavage, in the production of two 34 amino acid long peptides, ADan and ABri, that accumulate as amyloids in the brains of patients affected by familial Danish and British Dementia. To systematically explore the consequences of Bri2 C-termina...
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作者：Brandt, Anthony; Lesmana, Cokorda Bagus Jaya; Goldberg, Elkhonon
作者单位：Rice University; Universitas Udayana
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作者：Kolosova, Olga; Zgadzay, Yury; Stetsenko, Artem; Sukhinina, Anastasia P.; Atamas, Anastasia; Validov, Shamil; Rogachev, Andrey; Usachev, Konstantin; Jenner, Lasse; Dmitriev, Sergey E.; Yusupova, Gulnara; Guskov, Albert; Yusupov, Marat
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Groningen; Lomonosov Moscow State University; Lomonosov Moscow State University; Kazan Federal University; Joint Institute for Nuclear Research - Russia
摘要：Nonsense mutations are associated with numerous and diverse pathologies, yet effective treatment strategies remain elusive. A promising approach to combat these conditions involves the use of aminoglycosides, particularly in combination with stop-codon read-through enhancers, for developing drugs that can rescue the production of full-length proteins. Using X-ray crystallography and single-particle cryo-EM, we obtained structures of the eukaryotic ribosome in complexes with several aminoglycos...
