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作者：Chen, Chen; Yi, Ruiqin; Igisu, Motoko; Afrin, Rehana; Sithamparam, Mahendran; Chandru, Kuhan; Ueno, Yuichiro; Sun, Linhao; Laurenzi, Tommaso; Eberini, Ivano; Fraccia, Tommaso P.; Wang, Anna; Cleaves, H. James; Jia, Tony Z.
作者单位：Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia; University of Duisburg Essen; Kanazawa University; University of Milan; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; Howard University
摘要：alpha- hydroxy acids (alpha HAs), simple and prebiotically plausible organic monomers, were likely present in various environments on and off Earth and could have played a role in directing the emergence of the first homochiral living systems. Some alpha HAs, which could have been of varying chirality, can undergo dehydration polymerization into polyesters, which could assemble into membraneless microdroplets upon rehydration; understanding these processes is critical for unraveling how simple...
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作者：Chen, Feifei; Chen, Wei; Qiu, Huanguang
作者单位：China University of Mining & Technology; Renmin University of China; Liaoning University
摘要：Deforestation frequently accompanies poverty, yet various antipoverty programs in many countries have exhibited mixed results in addressing deforestation. Poverty Alleviation Resettlement (PAR) stands out as one of the few government-led resettlement programs designed to alleviate poverty, offering comprehensive follow-up support for quality of life and employment after relocation. Our study uncovered empirical evidence of the PAR program's impact on forest quality. Through a multiperiod diffe...
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作者：Dendene, Sara; Xue, Shuanghong; Mohammedi, Roza; Vieillard, Adam; Nicoud, Quentin; Valette, Odile; Frascella, Angela; Bonnardel, Anna; Le Bars, Romain; Bourge, Mickael; Mergaert, Peter; Brilli, Matteo; Alunni, Benoit; Biondi, Emanuele G.
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; University of Milan; AgroParisTech; INRAE; Universite Paris Saclay
摘要：Sinorhizobium meliloti is a soil bacterium that establishes a nitrogen- fixing symbiosis within root nodules of legumes. In this symbiosis, S. meliloti undergoes a drastic cellular change leading to a terminally differentiated form, called bacteroid, characterized by genome endoreduplication, increased cell size, and high membrane permeability. Bacterial cell cycle (mis)regulation is at the heart of this differentiation process. In free- living cells, the master regulator CtrA ensures the prog...
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作者：Deng, Xingguang; He, Ying; Tang, Xiaoya; Liu, Xianghong; Lee, Yuh-Ru Julie; Liu, Bo; Lin, Honghui
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作者：Wu, Nathan; Zhou, Baohua; Agrochao, Margarida; Clark, Damon A.
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
摘要：Our intuition suggests that when a movie is played in reverse, our perception of motion at each location in the reversed movie will be perfectly inverted compared to the original. This intuition is also reflected in classical theoretical and practical models of motion estimation, in which velocity flow fields invert when inputs are reversed in time. However, here we report that this symmetry of motion perception upon time reversal is broken in real visual systems. We designed a set of visual s...
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作者：Cheng, Xuanbing; Li, Zongqi; Zhu, Jialun; Wang, Jingyu; Huang, Ruyi; Yu, Lewis W.; Lin, Shuyu; Forman, Sarah; Gromilina, Evelina; Puri, Sameera; Patel, Pritesh; Bahramian, Mohammadreza; Tan, Jiawei; Hojaiji, Hannaneh; Jelinek, David; Voisin, Laurent; Yu, Kristie B.; Zhang, Ao; Ho, Connie; Lei, Lei; Coller, Hilary A.; Hsiao, Elaine Y.; Reyes, Beck L.; Matsumoto, Joyce H.; Lu, Daniel C.; Liu, Chong; Milla, Carlos; Davis, Ronald W.; Emaminejad, Sam
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Stanford University; Stanford University; University of California System; University of California Los Angeles
摘要：Mimicking metabolic pathways on electrodes enables in vivo metabolite monitoring for decoding metabolism. Conventional in vivo sensors cannot accommodate underlying complex reactions involving multiple enzymes and cofactors, addressing only a fraction of enzymatic reactions for few metabolites. We devised a single- wall- carbon- nanotube- electrode architecture supporting tandem metabolic pathway-like reactions linkable to oxidoreductase- based electrochemical analysis, making a vast majority ...
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作者：Cotting, Gabriel; Urquidi, Oscar; Besnard, Celine; Brazard, Johanna; Adachi, Takuji B. M.
作者单位：University of Geneva; University of Geneva
摘要：Molecular-level understanding of the early stage of crystallization remains a significant challenge. For a wide range of fundamental research and applications, it is of great importance to understand the mechanism of crystal polymorph selections in different solvents or in the presence of additives. We studied glycine crystallization in aqueous solution with or without the addition of sodium chloride (NaCl), one crystal nucleation at a time, using the recently developed single-crystal nucleati...
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作者：Meng, Luming; Sheong, Fu Kit; Luo, Qiong
作者单位：South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Hong Kong University of Science & Technology; South China Normal University
摘要：DNA is heterogeneously packaged into chromatin, which is further organized into topologically associating domains (TADs) with sharp boundaries. These boundary locations are critical for genome regulation. Here, we explore how the distribution of DNA- packing density across chromatin affects the TAD boundary locations. We develop a polymer- physics- based model that utilizes DNA accessibility data to parameterize DNA- packing density along chromosomes, treating them as heteropolymers, and simul...
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作者：Oluoch, Peter O.; Koh, Eun- Ik; Proulx, Megan K.; Reames, Charlotte J.; Papavinasasundaram, Kadamba G.; Murphy, Kenan C.; Zimmerman, Matthew D.; Dartois, Veronique; Sassetti, Christopher M.
作者单位：University of Massachusetts System; University of Massachusetts Worcester
摘要：Successful tuberculosis therapy requires treatment with an unwieldy multidrug combi- nation for several months. Thus, there is a growing need to identify novel genetic vul- nerabilities that can be leveraged to develop new, more effective antitubercular drugs. Consequently, recent efforts to optimize tuberculosis (TB) therapy have exploited Mycobacterium tuberculosis (Mtb) chemical genetics to identify pathways influencing antibiotic efficacy, novel mechanisms of antibiotic action, and new tar...
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作者：Ye, Michael; Diering, Graham H.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
