Proceedings of the National Academy of Sciences of the United States of America

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• Targeting PBK with small-molecule 1-O-acetyl-4R,6S-britannilactone for the treatment of neuroinflammation AI翻译
  作者：Zhang, Juan; Zhang, Hui-Lin; Xu, Xin-Rong; Feng, Yan-Li; Zhu, Qi-Meng; Morisseau, Christophe; Qiu, Feng; Hammock, Bruce D.; Sun, Cheng-Peng
  作者单位：Tianjin University of Traditional Chinese Medicine; University of California System; University of California Davis
  摘要：Neuroinflammation is a complex immunological phenomenon characterized by a dysregulated inflammatory response in the central nervous system (CNS) that can be triggered by various pathological injuries, such as toxins, which are involved in Parkinson's and Alzheimer's diseases (PD and AD), therefore, suppressing neuroinflammation serves as an effective treatment for CNS diseases. Herein, we found that natural soluble epoxide hydrolase (sEH) inhibitor 1-O-acetyl-4R,6S-britannilactone (AB) regula...
• Expressing intentions is not climate action AI翻译
  作者：Dablander, Fabian; Lange, Florian; Brick, Cameron; Aron, Adam R.
  作者单位：University of Amsterdam; University of Amsterdam; KU Leuven; University of Amsterdam; University of California System; University of California San Diego
• Genome analyses suggest recent speciation and postglacial isolation in the Norwegian lemming AI翻译
  作者：Lord, Edana; Feinauer, Isabelle S.; Soares, Andre E. R.; Lagerholm, Vendela K.; Naesvall, Karin; Ersmark, Erik; Olsen, Remi- Andre; Prost, Stefan; Kuzmina, Elena A.; Smirnov, Nickolay G.; Stewart, John R.; V. Knul, Monika; Noiret, Pierre; Germonpre, Mietje; Ehrich, Dorothee; Pokrovsky, Ivan; Fedorov, Vadim B.; V. Goropashnaya, Anna; Dalen, Love; Diez-del-Molino, David
  作者单位：Swedish Museum of Natural History; Stockholm University; Swedish Museum of Natural History; Uppsala University; Stockholm University; Wellcome Trust Sanger Institute; Stockholm University; University of Vienna; South African National Biodiversity Institute; Russian Academy of Sciences; Institute of Plant & Animal Ecology of the Russian Academy of Sciences; Bournemouth University; University of Winchester; University of Liege; Royal Belgian Institute of Natural Sciences; UiT The Arctic University of Tromso; Max Planck Society; University of Alaska System; University of Alaska Fairbanks
  摘要：The Norwegian lemming (Lemmus lemmus) is a small rodent distributed across the Fennoscandian mountain tundra and the Kola Peninsula. The Norwegian lemming likely evolved during the Late Pleistocene and inhabited Fennoscandia shortly prior to the Last Glacial Maximum. However, the exact timing and origins of the species, and its phylogenetic position relative to the closely related Siberian lemming (Lemmus sibiricus) remain disputed. Moreover, the presence of ancient or contemporary gene flow b...
• Mycophenolic acid treatment drives the emergence of novel SARS-CoV-2 variants AI翻译
  作者：Meister, Toni Luise; Nocke, Maximilian K.; Heinen, Natalie; Burkard, Thomas L.; Brueggemann, Yannick; Westhoven, Saskia; Trueb, Bettina; Ebert, Nadine; Thomann, Lisa; Lubieniecki, Krzysztof P.; Lubieniecka, Joanna M.; Doering, Kristina; Herrmann, Maike; Haid, Sibylle; Pietschmann, Thomas; Wiegmann, Bettina; Tao, Ronny; Pfefferle, Susanne; Addo, Marylyn M.; Thiel, Volker; Drexler, Ingo; Babel, Nina; Nguyen, Huu Phuc; Brown, Richard J. P.; Todt, Daniel; Steinmann, Elike; Pfaender, Stephanie
  作者单位：Ruhr University Bochum; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; German Center for Infection Research; Ruhr University Bochum; University of Bern; Ruhr University Bochum; Paul Ehrlich Institute; Helmholtz Association; Helmholtz-Center for Infection Research; Hannover Medical School; Hannover Medical School; Hannover Medical School; Heinrich Heine University Dusseldorf; University of Hamburg; University Medical Center Hamburg-Eppendorf; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin; University of Bern; Ruhr University Bochum; St. Marien Hospital; Ruhr University Bochum; St. Marien Hospital; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; German Center for Infection Research; University of Lubeck
  摘要：Mycophenolic acid (MPA) is commonly used in immunosuppressive regimens following solid organ transplantation. We demonstrate that MPA treatment reproducibly inhibits the replication of a range of viruses, including severe respiratory syndrome coronavirus 2 (SARS-CoV-2). Mechanistically, we identified cellular guanosine triphosphate pool depletion as a key mediator of this antiviral effect. Strikingly, this inhibition can be overcome which was correlated with the emergence of three breakthrough...
• Spin-informed universal graph neural networks for simulating magnetic ordering AI翻译
  作者：Xu, Wenbin; Sanspeur, Rohan Yuri; Kolluru, Adeesh; Deng, Bowen; Harrington, Peter; Farrell, Steven; Reuter, Karsten; Kitchin, John R.
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Carnegie Mellon University; Max Planck Society; Fritz Haber Institute of the Max Planck Society
  摘要：The screening and discovery of magnetic materials are hindered by the computational cost of first-principles density-functional theory (DFT) calculations required to find the ground state magnetic ordering. Although universal machine-learning interatomic potentials (uMLIPs), also known as atomistic foundation models, offer high-fidelity models of many atomistic systems with significant speedup, they currently lack the inputs required for predicting magnetic ordering. In this work, we present a...
• GSK3β phosphorylated tau filaments are probably not like those from AD brains AI翻译
  作者：Scheres, Sjors H. W.
  作者单位：MRC Laboratory Molecular Biology
• Diffusion-limited settling of highly porous particles in density-stratified fluids AI翻译
  作者：Hunt, Robert; Camassa, Roberto; McLaughlin, Richard M.; Harris, Daniel M.
  作者单位：Brown University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：The vertical transport of solid material in a stratified medium is fundamental to a number of environmental applications, with implications for the carbon cycle and nutrient transport in marine ecosystems. In this work, we study the diffusion-limited settling of highly porous particles in a density-stratified fluid through a combination of experiment, analysis, and numerical simulation. By delineating and appealing to the diffusion-limited regime wherein buoyancy effects due to mass adaptation...
• ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection AI翻译
  作者：Liang, Chun; Zhai, Tian-Ying; Chen, Jin; Fang, Shu; Zhu, Yan; Liu, Li-Man; Yu, Ning; Zhao, Hong-Bo
  作者单位：Yale University; University of Kentucky
  摘要：Negative feedback of the cochlear efferent system plays a critical role in control of hearing sensitivity and protection from noise trauma. Type II auditory nerves (ANs) innervate outer hair cells (OHCs) in the cochlea and provide an input to the cochlear efferent system to achieve hearing sensitivity controlling and protection; in particular, medial olivocochlear efferent nerves innervate OHCs to control OHC electromotility, which is an active cochlear amplifier in mammals. However, little is...
• Rapid growth and the evolution of complete metamorphosis in insects (vol 121, e2402980121, 2024) AI翻译
  作者：Manthey, Christin; Metcalf, C. Jessica E.; Monaghan, Michael T.; Steiner, Ulrich K.; Rolff, Jens
• Impact of large- scale solar on property values in the United States: Diverse effects and causal mechanisms AI翻译
  作者：Hu, Chenyang; Chen, Zhenshan; Liu, Pengfei; Zhang, Wei; He, Xi; Bosch, Darrell
  作者单位：Virginia Polytechnic Institute & State University; University of Rhode Island
  摘要：As the renewable energy transition continues into less receptive communities, local opposition is expected to intensify, potentially slowing the process. Since the local impacts are neither well quantified nor widely recognized, we lack policies and common practices to mitigate the potential associated welfare loss in affected communities. Based on a nationwide dataset combining property transactions and large-scale solar photovoltaic (LSSPV) sites, we analyze the heterogeneous effects of LSSP...