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作者：Sefik, Esen; Philbrick, William; Zhang, Fengrui; Agrawal, Kriti; Van Lee, Brian; Sam, Johannes; Karatepe, Kutay; Zheng, Yunjiang; Liang, Kaixin; Peng, Sophia; Mirza, Haris; Rangavajhula, Athreya; Simon, Perrine; Arun, Neha; Babu, Priyanka; Eynon, Elizabeth; Chiorazzi, Michael; Shan, Liang; Halene, Stephanie; Luo, Hongbo R.; Rongvaux, Anthony; Kluger, Yuval; Flavell, Richard A.
作者单位：Yale University; Yale University; Yale University; Roche Holding; Yale University; Yale University; Yale University; Saint Louis University; Washington University (WUSTL); Yale University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Fred Hutchinson Cancer Center; Yale University; Howard Hughes Medical Institute; Yale University
摘要：Murine and human immune systems differ significantly, particularly within the myeloid lineage. Humanized mice, generated by transplanting human hematopoietic stem, progenitor cells into genetically modified mice, are invaluable to study human immune development and function in vivo. However, a major limitation of current models is suboptimal myelopoiesis, particularly lack of functional human neutrophils, hampering the modeling of human immune responses and chronic diseases. Here, we describe ...
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作者：Tobias, Joseph A.; Bullock, James M.; Dicks, Lynn V.; Forester, Brenna R.; Razgour, Orly
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作者：Vu, Han N.; Lee, Minhyeong; Situ, Alan J.; An, Woojin; Ley, Klaus; Kim, Chungho; Ulmer, Tobias S.
作者单位：University of Southern California; Korea University; University of Southern California; University System of Georgia; Augusta University
摘要：In biological membranes, proteins face a fundamentally different environment than in water. To avoid untenable lipid contacts with polar backbone atoms, they use the continuous hydrogen bonding achieved by alpha- helices or beta- barrels to traverse membranes. Here, we show that integrin alpha X, and by homology alpha M, undermine this paradigm by partially unfolding the N-terminal third of their transmembrane (TM) helix. Unfolding results in a dynamic, frayed helix that weakens the associatio...
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作者：Zhang, Yi-Bao; Li, Lu; Fan, Yaning; Su, Jinghong; Xi, Heng-Dong; Sun, Chao
作者单位：Tsinghua University; Southern University of Science & Technology; Southern University of Science & Technology; China University of Petroleum; Northwestern Polytechnical University; Tsinghua University
摘要：Elastic turbulence (ET) and elastoinertial turbulence (EIT) of viscoelastic fluids are unique flow states with features distinct from the inertial turbulence of Newtonian fluids. Whether these two states are connected or entirely decoupled remains controversial. We here resolve this controversy by providing experimental evidence of a continuous transition between ET and EIT in Taylor-Couette flow. Through experimentally quantifying the roles of elasticity and inertia in flow stability, we find...
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作者：Dai, Jun; Chen, Chuan; Zhai, Zhi - Qiang; Gao, A. - Xiang; Johnson, David R.; Kopittke, Peter M.; Zhao, Fang - Jie; Wang, Peng
作者单位：Nanjing Agricultural University; Nanjing Agricultural University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Bern; University of Queensland
摘要：Arsenic contamination in rice poses a global challenge to food safety and agricultural productivity, as toxic methylated arsenic species-dimethylarsinic acid (DMA) and its highly toxic derivative, methylated monothioarsenate (DMMTA)-accumulate in rice grains. These arsenic species endanger human health and trigger rice straighthead disease, a crop disorder that drastically reduces yields. However, the microbial ecological processes driving arsenic speciation in paddy soils, and their link to s...
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作者：Cai, Zhaoxian; Wu, Xiaotian; Wang, Tianyi; Song, Zijun; Ni, Pu; Zhong, Meijuan; Su, Yunxing; Xie, Enjun; Sun, Shumin; Lin, Yangjun; Min, Junxia; Wang, Fudi
作者单位：Zhejiang University; Zhejiang University; University of South China
摘要：While numerous genetic risk loci are linked to kidney disease, a unifying therapeutic target for diverse renal pathologies remains elusive. Here, through large-cohort polymorphic locus screening, we identify the SLC39A8 A391T variant (rs13107325) as a shared modifier of multiple kidney diseases. Functional characterization using Slc39a8 A391T knock-in mice and kidney-specific Slc39a8 knockout mice reveals that loss of SLC39A8 function reduces renal zinc accumulation, thereby mitigating suscept...
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作者：Faber, Justin; Alampounti, Alexandros C.; Georgiades, Marcos; Albert, Joerg T.; Bozovic, Dolores
作者单位：University of California System; University of California Los Angeles; University of London; University College London; Carl von Ossietzky Universitat Oldenburg; University of California System; University of California Los Angeles
摘要：Distortion products are tones produced through nonlinear effects of a system simultaneously detecting two or more frequencies. These combination tones are ubiquitous to vertebrate auditory systems and are generally regarded as byproducts of nonlinear signal amplification. It has previously been shown that several species of infectious-disease-carrying mosquitoes utilize these distortion products for detecting and locating potential mates. Furthermore, the mechanical tuning curve of the male mo...
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作者：Pang, Xiaoyun; Zhang, Yan; Park, Kunyou; Liao, Zhenyu; Li, Jian; Xu, Jiashu; Hong, Minh-Triet; Yin, Guoliang; Zhang, Tongming; Wang, Yaoyu; Egelman, Edward H.; Fan, Jun; Hsu, Victor W.; Park, Seung-Yeol; Sun, Fei
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作者：Jenne, Craig; Kubes, Paul
作者单位：University of Calgary; University of Calgary; Queens University - Canada
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作者：Luo, Jing; Chia, Natalie; Qin, Yuxi; Tan, Pan; Zhang, Lingwen; Yang, Sihan; Yuan, Zihan; Hong, Liang; Lee, Sang Yup; Tong, Yaojun
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
摘要：Streptomyces are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in synthetic biology applications given the abundance of uncharacterized biosynthetic gene clusters (BGCs). However, progress has been hindered by the limited availability of genetic tools for manipulating these bacteria. Several representative CRISPR-Cas systems have been established in Streptomyces to streamline experim...
