Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Sociohydrodynamics: Data-driven modeling of social behavior AI翻译
  作者：Seara, Daniel S.; Colen, Jonathan; Fruchart, Michel; Avni, Yael; Martin, David G.; Vitelli, Vincenzo
  作者单位：University of Chicago; University of Chicago; Old Dominion University; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University of Chicago; University of Chicago
  摘要：Living systems display complex behaviors driven by physical forces as well as decisionof socially generated collective behaviors. However, the construction of such theories is often divorced from the data they should describe. Here, we develop and apply a data-driven pipeline that links micromotives to macrobehavior by augmenting hydrodynamics with individual preferences that guide motion. We illustrate this pipeline on a case study of residential dynamics in the United States, for which censu...
• Pervasive and recurrent hybridization prevents inbreeding in Europe's most threatened seabird AI翻译
  作者：Izquierdo-Aranega, Guillem; Cuevas-Caballe, Cristian; Giannelli, Francesco; Paris, Josephine R.; Bourgeois, Karen; Trucchi, Emiliano; Gonzalez-Solis, Jacob; Riutort, Marta; Obiol, Joan Ferrer; Rozas, Julio
  作者单位：University of Barcelona; University of Barcelona; University of Barcelona; Marche Polytechnic University; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Avignon Universite; Institut de Recherche pour le Developpement (IRD); University of Milan; Colorado State University System; Colorado State University Fort Collins
  摘要：Hybridization is a double- edged sword: While it can erode distinct evolutionary lineages, it can also introduce genetic diversity and adaptive potential into dwindling populations. In the Critically Endangered Balearic shearwater (Puffinus mauretanicus), this dilemma is exacerbated by a limited understanding of the extent and consequences of hybridization with the Yelkouan shearwater (Puffinus yelkouan). This knowledge gap has limited the scope of science- based conservation strategies to avo...
• Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis AI翻译
  作者：Khan, Fatima; Liu, Yang; Whitfield, Donovan; Pang, Lizhi; Ali, Heba; Huang, Yuyun; Zhou, Fei; Hagan, Robert S.; Frenis, Katie; Rowe, R. Grant; Chen, Peiwen
  作者单位：Cleveland Clinic Foundation; Northwestern University; Feinberg School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University System of Ohio; Case Western Reserve University
  摘要：Tumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment that promote breast cancer brain metastasis (BCBM). Here, we identify TANK-binding kinase (TBK1) as a critical signaling molecule enriched and activated in TAMs of BCBM tumors, playing an indispensable role in BCBM development and metastatic outgrowth in the brain. Mechanistically, BCBM cell-secreted matrix metalloproteinase 1 binds to protease-activated receptor 1 and integrin alpha V beta 5 on ...
• The nature of ant caste allometry AI翻译
  作者：Linksvayer, Timothy A.
  作者单位：Arizona State University; Arizona State University-Tempe
• Definition of the components required for selective packaging of coronavirus genomic RNA AI翻译
  作者：Pata, Janice D.; Stevens, Taina K.; Kuo, Lili; Masters, Paul S.
  作者单位：State University of New York (SUNY) System; Wadsworth Center; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; Wadsworth Center
  摘要：Most cytoplasmic RNA viruses have evolved mechanisms to identify their genomic RNA (gRNA) as the sole RNA species to be packaged into assembled virions. Coronaviruses exhibit highly selective packaging of their gRNA, in spite of the presence of a large excess of subgenomic viral and host RNA in infected cells. Failure to accomplish this selectivity does not impair virion assembly but renders the virus vulnerable to host innate immunity. In the prototype coronavirus mouse hepatitis virus (MHV) ...
• Tuning water dissociation at oxide-electrolyte interfaces with electric fields AI翻译
  作者：Zhang, Chunyi; Yu, Zheng; Car, Roberto; Selloni, Annabella
  作者单位：Princeton University; Eastern Institute of Technology, Ningbo
  摘要：Understanding how electric fields influence water dissociation at heterogeneous interfaces is crucial for controlling interfacial chemical reactions and advancing next-generation energy technologies. Herein, ab initio-based machine learning simulations show that even small electric field changes can significantly alter the water dissociation fraction at planar TiO2-electrolyte interfaces. The resulting free energy difference between undissociated and dissociated interfacial water exhibits a li...
• Ludwig-Soret microscopy with the vibrational photothermal effect AI翻译
  作者：Toda, Keiichiro; Ideguchi, Takuro
  作者单位：University of Tokyo
  摘要：Vibrational microscopy provides label-free, bond-selective chemical contrast by detecting molecular vibrations, making it invaluable for biomedical research. While conventional methods rely on the direct detection of Raman scattering or infrared absorption, recently developed vibrational photothermal (ViP) microscopy achieves chemical contrast indirectly through refractive index (RI) changes. This indirect approach enables unique imaging capabilities beyond traditional chemical imaging. Here, ...
• Reduction of TRAF3 by heterozygosity or aging impacts B cell function AI翻译
  作者：Hornick, Emma L.; Oxley, Kyp; Wieting, Nathaniel; Treco, Emma; Hostager, Bruce S.; Bishop, Gail A.
  作者单位：University of Iowa; University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System
  摘要：TNF receptor-associated factor 3 (TRAF3) is a signaling adaptor protein that is ubiquitously expressed but has highly distinct cell type-specific functions. TRAF3 plays critical roles in restraint of B lymphocyte activation, differentiation, and homeostatic survival. Consistent with such roles, loss-of-function mutations in TRAF3 have long been found in various human B cell malignancies. Mice lacking TRAF3 specifically in B cells have autoimmune manifestations, lymphadenopathy, and increased i...
• Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation AI翻译
  作者：Miller, Shannon L.; Green, Katelyn M.; Crone, Bradley; Switzenberg, Jessica A.; Tank, Elizabeth M. H.; Krans, Amy; Jansen-West, Karen; Wieland, Clare M.; Ji, Eric W.; Petrucelli, Leonard; Barmada, Sami J.; Boyle, Alan P.; Todd, Peter K.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Mayo Clinic; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Intronic GGGGCC hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Despite its intronic location, this repeat avidly supports synthesis of pathogenic dipeptide repeat (DPR) proteins via repeat-associated non-AUG (RAN) translation. However, the template RNA species that undergoes RAN translation endogenously remains unclear. Using long-read based 5 ' RNA ligase-mediated rapid amplification of cD...
• General anesthesia in early infancy accelerates visual cortical development AI翻译
  作者：Gabard-Durnam, Laurel J.; McCormick, Sarah A.; Underwood, Ellen; Tao, Alice; Kim, Isabelle; Coffman, Siobhan; Benster, Lindsay; Graziano, Maria; Nelson, Charles A.; Berde, Charles B.; Cornelissen, Laura; Hensch, Takao K.
  作者单位：Northeastern University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Tokyo; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University
  摘要：How human brain function is established through protracted trajectories of development is not yet fully understood. Maturation of gamma- aminobutyric acid (GABA) circuits drives critical periods of cortical development in animal models. Whether early functional inhibition similarly impacts the pace of human brain development remains unknown. Here, in a longitudinal study of 93 infants across a range of repeated exposures to general anesthesia shortly after birth, we observed a dramatically acc...