Nature

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• Magnetic field effects on behaviour in Drosophila AI翻译
  作者：Reppert, Steven M.
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
• Air-travel climate-change emissions detailed for nearly 200 nations AI翻译
  作者：[Anonymous]
  摘要：Carbon emissions from flights that departed from low- and middle-income countries in 2019 totalled 417 million tonnes.
• Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase AI翻译
  作者：Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodiles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Pettazzoni, Piergiorgio; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Patricelli, Matthew P.; Kinsella, Todd M.
  作者单位：Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Vall d'Hebron Institut d'Oncologia (VHIO)
  摘要：WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms1-5. Currently there are no approved drugs directly targeting human DNA or RNA helicases, in part owing to the challenging nature of developing potent and selective compounds to this class of proteins. Here we describe the chemoproteomics-enabled discovery ...
• 'Shut up and calculate': how Einstein lost the battle to explain quantum reality AI翻译
  作者：Baggott, Jim
  摘要：By suppressing questions they considered too 'philosophical', post-war physicists created an unquestioning orthodoxy that influences science to this day.
• Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids AI翻译
  作者：Auger, Jean-Philippe; Zimmermann, Max; Faas, Maria; Stifel, Ulrich; Chambers, David; Krishnacoumar, Brenda; Taudte, R. Verena; Grund, Charlotte; Erdmann, Gitta; Scholtysek, Carina; Uderhardt, Stefan; Ben Brahim, Oumaima; Mate, Monica Pascual; Stoll, Cornelia; Boettcher, Martin; Palumbo-Zerr, Katrin; Mangan, Matthew S. J.; Dzamukova, Maria; Kieler, Markus; Hofmann, Melanie; Blueml, Stephan; Schabbauer, Gernot; Mougiakakos, Dimitrios; Sonnewald, Uwe; Hartmann, Fabian; Simon, David; Kleyer, Arnd; Grueneboom, Anika; Finotto, Susetta; Latz, Eicke; Hofmann, Joerg; Schett, Georg; Tuckermann, Jan; Kroenke, Gerhard
  作者单位：University of Erlangen Nuremberg; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Ulm University; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Duisburg Essen; University of Erlangen Nuremberg; Philipps University Marburg; Helmholtz Association; German Cancer Research Center (DKFZ); University of Erlangen Nuremberg; Otto von Guericke University; University of Bonn; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Medical University of Vienna; Medical University of Vienna; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ)
  摘要：Glucocorticoids represent the mainstay of therapy for a broad spectrum of immune-mediated inflammatory diseases. However, the molecular mechanisms underlying their anti-inflammatory mode of action have remained incompletely understood(1). Here we show that the anti-inflammatory properties of glucocorticoids involve reprogramming of the mitochondrial metabolism of macrophages, resulting in increased and sustained production of the anti-inflammatory metabolite itaconate and consequent inhibition...
• I strive to make the Great Barrier Reef more resilient to heat stress AI翻译
  作者：Crow, James Mitchell; Nitschke, Matthew
  作者单位：Australian Institute of Marine Science; Victoria University Wellington
• Support those who will lose out in the energy transition AI翻译
  作者：[Anonymous]
• FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy AI翻译
  作者：Chan, Jack D.; Scheffler, Christina M.; Munoz, Isabelle; Sek, Kevin; Lee, Joel N.; Huang, Yu-Kuan; Yap, Kah Min; Saw, Nicole Y. L.; Li, Jasmine; Chen, Amanda X. Y.; Chan, Cheok Weng; Derrick, Emily B.; Todd, Kirsten L.; Tong, Junming; Dunbar, Phoebe A.; Li, Jiawen; Hoang, Thang X.; de Menezes, Maria N.; Petley, Emma V.; Kim, Joelle S.; Nguyen, Dat; Leung, Patrick S. K.; So, Joan; Deguit, Christian; Zhu, Joe; House, Imran G.; Kats, Lev M.; Scott, Andrew M.; Solomon, Benjamin J.; Harrison, Simon J.; Oliaro, Jane; Parish, Ian A.; Quinn, Kylie M.; Neeson, Paul J.; Slaney, Clare Y.; Lai, Junyun; Beavis, Paul A.; Darcy, Phillip K.
  作者单位：Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; University of Melbourne; Royal Melbourne Institute of Technology (RMIT); La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; University of Melbourne; Peter Maccallum Cancer Center; Melbourne Health; Royal Melbourne Hospital; Monash University; Monash University
  摘要：Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma 1-4 , but the efficacy of CAR T cell therapy in solid tumours has been limited 5 . This is owing to a number of factors, including the immunosuppressive tumour microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. Analysis of anti-CD19 CAR T cells used clinically has shown...
• How volcanoes shaped our planet - and why we need to be ready for the next big eruption AI翻译
  作者：Handley, Heather
  作者单位：University of Twente
  摘要：The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us. The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us.
• Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia AI翻译
  作者：Koeberl, Dwight; Schulze, Andreas; Sondheimer, Neal; Lipshutz, Gerald S.; Geberhiwot, Tarekegn; Li, Lerong; Saini, Rajnish; Luo, Junxiang; Sikirica, Vanja; Jin, Ling; Liang, Min; Leuchars, Mary; Grunewald, Stephanie
  作者单位：Duke University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of California System; University of California Los Angeles; University of Birmingham; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of London; University College London
  摘要：Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase alpha or beta (PCCA or PCCB) subunits that leads to an accumulation of toxic metabolites and to recurrent, life-threatening metabolic decompensation events. Here we report interim analyses of a first-in-human, phase 1/2, open-label, dose-optimization study and an extension study evaluating the safety and efficacy of mRNA-3927, a dual mRNA therapy encoding PCCA and PCCB. As of 31 May 2023, 16 partic...