作者：Amar, David; Gay, Nicole R.; Jean-Beltran, Pierre M.; Bae, Dam; Dasari, Surendra; Dennis, Courtney; Evans, Charles R.; Gaul, David A.; Ilkayeva, Olga; Ivanova, Anna A.; Kachman, Maureen T.; Keshishian, Hasmik; Lanza, Ian R.; Lira, Ana C.; Muehlbauer, Michael J.; Nair, Venugopalan D.; Piehowski, Paul D.; Rooney, Jessica L.; Smith, Kevin S.; Stowe, Cynthia L.; Zhao, Bingqing; Clark, Natalie M.; Jimenez-Morales, David; Lindholm, Malene E.; Many, Gina M.; Sanford, James A.; Smith, Gregory R.; Vetr, Nikolai G.; Zhang, Tiantian; Armenteros, Jose J. Almagro; Avila-Pacheco, Julian; Bararpou, Nasim; Ge, Yongchao; Hou, Zhenxin; Marwaha, Shruti; Presby, David M.; Raja, Archana Natarajan; Savage, Evan M.; Steep, Alec; Sun, Yifei; Wu, Si; Zhen, Jimmy; Bodine, Sue C.; Esser, Karyn A.; Goodyear, Laurie J.; Schenk, Simon; Montgomery, Stephen B.; Fernandez, Facundo M.; Sealfon, Stuart C.; Snyder, Michael P.; Adkins, Joshua N.; Ashley, Euan; Burant, Charles F.; Carr, Steven A.; Clish, Clary B.; Cutter, Gary; Gerszten, Robert E.; Kraus, William E.; Li, Jun Z.; Miller, Michael E.; Nair, K. Sreekumaran; Newgard, Christopher; Ortlund, Eric A.; Qian, Wei-Jun; Tracy, Russell; Wheeler, Matthew T.; Dalton, Karen P.; Hastie, Trevor; Hershman, Steven G.; Samdarshi, Mihir; Teng, Christopher; Tibshirani, Rob; Cornell, Elaine; Gagne, Nicole; May, Sandy; Bouverat, Brian; Leeuwenburgh, Christiaan; Lu, Ching-ju; Pahor, Marco; Hsu, Fang-Chi; Rushing, Scott; Walkup, Michael P.; Nicklas, Barbara; Rejesk, W. Jack; Williams, John P.; Xia, Ashley; Albertson, Brent G.; Barton, Elisabeth R.; Booth, Frank W.; Caputo, Tiziana; Cicha, Michael; De Sousa, Luis Gustavo Oliveira; Farrar, Roger; Hevener, Andrea L.; Hirshman, Michael F.; Jackson, Bailey E.; Ke, Benjamin G.; Kramer, Kyle S.; Lessard, Sarah J.; Makarewicz, Nathan S.; Marshall, Andrea G.; Nigro, Pasquale; Powers, Scott; Ramachandran, Krithika; Recto, R. Scott; Richards, Collyn Z-T.; Thyfault, John; Yan, Zhen; Zang, Chongzhi; Amper, Mary Anne S.; Balci, Ali Tugrul; Chavez, Clarisa; Chikina, Maria; Chiu, Roxanne; Gritsenko, Marina A.; Guevara, Kristy; Hansen, Joshua R.; Hennig, Krista M.; Hung, Chia-Jui; Hutchinson-Bunch, Chelsea; Jin, Christopher A.; Liu, Xueyun; Maner-Smith, Kristal M.; Mani, D. R.; Marjanovic, Nada; Monroe, Matthew E.; Moore, Ronald J.; Moore, Samuel G.; Mundorff, Charles C.; Nachun, Daniel; Nestor, Michael D.; Nudelman, German; Pearce, Cadence; Petyuk, Vladislav A.; Pincas, Hanna; Ramos, Irene; Raskind, Alexander Sasha; Rirak, Stas; Robbins, Jeremy M.; Rubenstein, Aliza B.; Ruf-Zamojski, Frederique; Sagendorf, Tyler J.; Seenarine, Nitish; Soni, Tanu; Uppal, Karan; Vangeti, Sindhu; Vasoya, Mital; Vornholt, Alexandria; Walsh, Martin J.; Yu, Xuechen; Zaslavsky, Elena; Zebarjadi, Navid; Bamman, Marcas; Bergman, Bryan C.; Bessesen, Daniel H.; Buford, Thomas W.; Chambers, Toby L.; Coen, Paul M.; Cooper, Dan; Haddad, Fadia; Gadde, Kishore; Goodpaste, Bret H.; Harris, Melissa; Huffman, Kim M.; Jankowsk, Catherine M.; Johannsen, Neil M.; Kohr, Wendy M.; Kraus, William E.; Lester, Bridget; Melanson, Edward L.; Moreau, Kerrie L.; Musi, Nicolas; Newton, Robert L., Jr.; Radom-Aizik, Shlomit; Ramaker, Megan E.; Rankinen, Tuomo; Rasmussen, Blake B.; Ravussin, Eric; Schauer, Irene E.; Schwartz, Robert S.; Sparks, Lauren M.; Thalacker-Mercer, Anna; Trappe, Scott; Trappe, Todd A.; Volpi, Elena
作者单位：Stanford University; Stanford University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Iowa; Mayo Clinic; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Michigan System; University of Michigan; University System of Georgia; Georgia Institute of Technology; Duke University; Duke University; Emory University; University of Michigan System; University of Michigan; Mayo Clinic; Icahn School of Medicine at Mount Sinai; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of Vermont; Stanford University; Wake Forest University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Emory University; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; University of Michigan System; University of Michigan; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Oklahoma Medical Research Foundation; State University System of Florida; University of Florida; University of California System; University of California San Diego; Stanford University; University of Alabama System; University of Alabama Birmingham; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Wake Forest University; Mayo Clinic; Stanford University; Stanford University; State University System of Florida; University of Florida; Wake Forest University; Wake Forest University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); State University System of Florida; University of Florida; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Texas System; University of Texas Austin; University of California System; University of California Los Angeles; University of Virginia; Harvard University; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Vanderbilt University; Stetson University; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Kansas; University of Kansas Medical Center; University of Virginia; University of Virginia; University of Virginia; University of Virginia; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Georgia; Georgia Institute of Technology; Emory University; University of Alabama System; University of Alabama Birmingham; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Alabama System; University of Alabama Birmingham; Ball State University; Adventist Health Services; AdventHealth; University of California System; University of California Irvine; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Colorado System; University of Colorado Anschutz Medical Campus; Cedars Sinai Medical Center; Louisiana State University System; Louisiana State University; Pennington Biomedical Research Center; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
摘要：Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood 1-3 . Here, the Molecular Transducers of Physical Activity Consortium 4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data...
作者：Zhao, Qinqin; Bertolli, Savannah; Park, Young-Jun; Tan, Yongjun; Cutler, Kevin J.; Srinivas, Pooja; Asfahl, Kyle L.; Fonesca-Garcia, Citlali; Gallagher, Larry A.; Li, Yaqiao; Wang, Yaxi; Coleman-Derr, Devin; DiMaio, Frank; Zhang, Dapeng; Peterson, S. Brook; Veesler, David; Mougous, Joseph D.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Saint Louis University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; United States Department of Agriculture (USDA); University of California System; University of California Berkeley; University of Washington; University of Washington Seattle; Saint Louis University
摘要：Streptomyces are a genus of ubiquitous soil bacteria from which the majority of clinically utilized antibiotics derive(1). The production of these antibacterial molecules reflects the relentless competition Streptomyces engage in with other bacteria, including other Streptomyces species(1,2). Here we show that in addition to small-molecule antibiotics, Streptomyces produce and secrete antibacterial protein complexes that feature a large, degenerate repeat-containing polymorphic toxin protein. ...
