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• The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer AI翻译
  作者：Abraham, Jean E.; Pinilla, Karen; Dayimu, Alimu; Grybowicz, Louise; Demiris, Nikolaos; Harvey, Caron; Drewett, Lynsey M.; Lucey, Rebecca; Fulton, Alexander; Roberts, Anne N.; Worley, Joanna R.; Chhabra, Anita; Qian, Wendi; Vallier, Anne-Laure; Hardy, Richard M.; Chan, Steve; Hickish, Tamas; Tripathi, Devashish; Venkitaraman, Ramachandran; Persic, Mojca; Aslam, Shahzeena; Glassman, Daniel; Raj, Sanjay; Borley, Annabel; Braybrooke, Jeremy P.; Sutherland, Stephanie; Staples, Emma; Scott, Lucy C.; Davies, Mark; Palmer, Cheryl A.; Moody, Margaret; Churn, Mark J.; Newby, Jacqueline C.; Mukesh, Mukesh B.; Chakrabarti, Amitabha; Roylance, Rebecca R.; Schouten, Philip C.; Levitt, Nicola C.; Mcadam, Karen; Armstrong, Anne C.; Copson, Ellen R.; Mcmurtry, Emma; Tischkowitz, Marc; Provenzano, Elena; Earl, Helena M.
  作者单位：University of Cambridge; Cancer Research UK; University of Cambridge; CRUK Cambridge Institute; University of Cambridge; University of Cambridge; Athens University of Economics & Business; University of Cambridge; University of Cambridge; Nottingham University Hospital NHS Trust; University of Nottingham; Russells Hall Hospital; Ipswich Hospital NHS Trust; Pinderfields Hospital; University of Southampton; University Hospital Southampton NHS Foundation Trust; Velindre Cancer Centre; Mount Vernon Cancer Centre; Beatson Oncology Centre; University of London; University College London; Royal Free London NHS Foundation Trust; University of London; University College London; University College London Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; Oxford University Hospitals NHS Foundation Trust; University of Manchester; Christie NHS Foundation Trust; University of Southampton; University of Cambridge
  摘要：PARTNER is a prospective, phase II-III, randomized controlled clinical trial that recruited patients with triple-negative breast cancer(1,2), who were germline BRCA1 and BRCA2 wild type(3). Here we report the results of the trial. Patients (n = 559) were randomized on a 1:1 basis to receive neoadjuvant carboplatin-paclitaxel with or without 150 mg olaparib twice daily, on days 3 to 14, of each of four cycles (gap schedule olaparib, research arm) followed by three cycles of anthracycline-based ...
• Don't overlook joints and bones in exercise studies AI翻译
  作者：Berenbaum, Francis
  作者单位：Sorbonne Universite
• The anti-cancer biological missile AI翻译
  作者：Plackett, Benjamin
• Suppressed thermal transport in silicon nanoribbons by inhomogeneous strain AI翻译
  作者：Yang, Lin; Yue, Shengying; Tao, Yi; Qiao, Shuo; Li, Hang; Dai, Zhaohe; Song, Bai; Chen, Yunfei; Du, Jinlong; Li, Deyu; Gao, Peng
  作者单位：Peking University; Xi'an Jiaotong University; Southeast University - China; Southeast University - China; Peking University; Peking University; Peking University; Vanderbilt University; Peking University
  摘要：Nanoscale structures can produce extreme strain that enables unprecedented material properties, such as tailored electronic bandgap(1-5), elevated superconducting temperature(6,7) and enhanced electrocatalytic activity(8,9). While uniform strains are known to elicit limited effects on heat flow(10-15), the impact of inhomogeneous strains has remained elusive owing to the coexistence of interfaces(16-20) and defects(21-23). Here we address this gap by introducing inhomogeneous strain through be...
• How does ChatGPT 'think'? Psychology and neuroscience crack open AI large language models AI翻译
  作者：Hutson, Matthew
  摘要：Researchers are striving to reverse-engineer artificial intelligence and scan the 'brains' of LLMs to see what they are doing, how and why.
• How to climate-proof India's economy AI翻译
  作者：Prabhu, Shravan
• Network-level encoding of local neurotransmitters in cortical astrocytes (vol 629, pg 146, 2024) AI翻译
  作者：Cahill, Michelle K.; Collard, Max; Tse, Vincent; Reitman, Michael E.; Etchenique, Roberto; Kirst, Christoph; Poskanzer, Kira E.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; University of California System; University of California San Francisco; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
• 'Critical minerals' debate risks being greenwashed AI翻译
  作者：Arratia-Solar, Andrea; Fleming-Munoz, David
  作者单位：University of Queensland; La Trobe University
• The intrinsic substrate specificity of the human tyrosine kinome AI翻译
  作者：Yaron-Barir, Tomer M.; Joughin, Brian A.; Huntsman, Emily M.; Kerelsky, Alexander; Cizin, Daniel M.; Cohen, Benjamin M.; Regev, Amit; Song, Junho; Vasan, Neil; Lin, Ting-Yu; Orozco, Jose M.; Schoenherr, Christina; Sagum, Cari; Bedford, Mark T.; Wynn, R. Max; Tso, Shih-Chia; Chuang, David T.; Li, Lei; Li, Shawn S-C; Creixell, Pau; Krismer, Konstantin; Takegami, Mina; Lee, Harin; Zhang, Bin; Lu, Jingyi; Cossentino, Ian; Landry, Sean D.; Uduman, Mohamed; Blenis, John; Elemento, Olivier; Frame, Margaret C.; Hornbeck, Peter V.; Cantley, Lewis C.; Turk, Benjamin E.; Yaffe, Michael B.; Johnson, Jared L.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Columbia University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Columbia University; NewYork-Presbyterian Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of Edinburgh; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Health & Rehabilitation Sciences; Western University (University of Western Ontario); University of Cambridge; Cancer Research UK; CRUK Cambridge Institute; Massachusetts Institute of Technology (MIT); Cell Signaling Technology; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Yale University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center
  摘要：Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth(1). Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that catalyse the phosphorylation of thousands of Tyr residues throughout the proteome(1-3). How a given Tyr kinase can phosphorylate a specific subset of proteins at unique Tyr sites is only partially understood(4-7). Here we used combinatorial peptide arrays to profile the substr...
• Low-latency automotive vision with event cameras AI翻译
  作者：Gehrig, Daniel; Scaramuzza, Davide
  作者单位：University of Zurich
  摘要：The computer vision algorithms used currently in advanced driver assistance systems rely on image-based RGB cameras, leading to a critical bandwidth-latency trade-off for delivering safe driving experiences. To address this, event cameras have emerged as alternative vision sensors. Event cameras measure the changes in intensity asynchronously, offering high temporal resolution and sparsity, markedly reducing bandwidth and latency requirements 1 . Despite these advantages, event-camera-based al...